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1.发明授权
公开(公告)号：US5965381A
公开(公告)日：1999-10-12
申请号：US36582
申请日：1998-03-06
Applicant: Pierre B. van der Bruggen , Guy R. Cornelis , Anne M. Boland , Thierry R. Boon-Falleur
IPC: C12N15/09 , A61K38/00 , A61K39/00 , A61K39/07 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/04 , C07K14/24 , C07K14/47 , C12N1/21 , C12N15/74 , C12N15/87 , C12Q1/02
CPC classification number: C12R1/01 , A61K48/00 , C07K14/24 , C07K14/4748 , C12N15/74 , C12N15/87 , A61K38/00
Abstract: The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
Abstract translation: 本发明涉及重组耶尔霉素及其用于将蛋白递送到真核细胞中的用途，包括相关组合物和治疗方法以及相关测定。
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公开(公告)号：US06710172B1
公开(公告)日：2004-03-23
申请号：US09806769
申请日：2001-07-30
Applicant: Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
Inventor： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC: C07H2104
CPC classification number: C07K14/4748
Abstract: The present invention relates to nucleic acid molecules encoding antigenic peptides from MAGE molecules that bind to HLA. An example of the nucleic acid molecules of the present invention is a nucleic acid molecule coding for the peptide GVYDGREHTV (SEQ ID NO: 44), which peptide binds to HLA-A2. The nucleic acid molecules and the encoded antigenic peptides are useful for diagnosing and treating various pathological conditions.
Abstract translation: 本发明涉及编码结合HLA的MAGE分子的抗原肽的核酸分子。 本发明的核酸分子的实例是编码肽GVYDGREHTV（SEQ ID NO：44）的核酸分子，该肽与HLA-A2结合。 核酸分子和编码的抗原肽可用于诊断和治疗各种病理状况。
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公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
Applicant: Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
Inventor： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
CPC classification number: C07K14/4748
Abstract: The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
Abstract translation: 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。
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公开(公告)号：US06602506B1
公开(公告)日：2003-08-05
申请号：US09318141
申请日：1999-05-25
Applicant: Pierre B. van der Bruggen , Guy R. Cornelis , Anne M. Boland , Thierry R. Boon-Falleur
IPC: A61K3902
CPC classification number: C12R1/01 , A61K38/00 , A61K48/00 , C07K14/24 , C07K14/4748 , C12N15/74 , C12N15/87
Abstract: The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
Abstract translation: 本发明涉及重组耶尔霉素及其用于将蛋白递送到真核细胞中的用途，包括相关组合物和治疗方法以及相关测定。
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