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    Immunomodulatory peptides derived from heat shock proteins and uses thereof
    2.
    发明授权
    Immunomodulatory peptides derived from heat shock proteins and uses thereof 有权
    衍生自热休克蛋白的免疫调节肽及其用途

    公开(公告)号：US07301005B2

    公开(公告)日：2007-11-27

    申请号：US10001938

    申请日：2001-10-31

    申请人： Salvatore Albani ,  Dennis A. Carson ,  Berent J Prakken ,  Alberto Martini

    发明人： Salvatore Albani ,  Dennis A. Carson ,  Berent J Prakken ,  Alberto Martini

    IPC分类号： C07K5/00

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K14/4702

    摘要： A method of modulating an immune response in a subject is disclosed. The invention is based on the discovery that an effective therapeutic strategy for ameliorating the inflammation-related symptoms of an immune-mediated disease, such as arthritis, can be achieved by modulation of the underlying immune response itself, rather than by merely addressing the resulting inflammation. This strategy can be used to regulate the inflammatory response and is applicable to a variety of contexts in which immune modulation is desired, such as mucosal tolerization, DNA vaccination, anergy induction, active immunization, and ex vivo modulation of antigen-specific T cells. In one embodiment, the method comprises administering to the subject a bacterial dnaJ peptide or a human homolog or a non-homologous human isoform thereof.

    摘要翻译： 公开了调节受试者的免疫应答的方法。 本发明基于以下发现：通过调节潜在的免疫应答本身而不是仅通过解决所产生的炎症来实现用于改善免疫介导的疾病如关节炎的炎症相关症状的有效治疗策略 。 该策略可用于调节炎症反应，适用于需要进行免疫调节的各种情况，例如粘膜耐受性，DNA疫苗接种，无能力诱导，主动免疫和抗原特异性T细胞的离体调节。 在一个实施方案中，所述方法包括向受试者施用细菌dnaJ肽或人同源物或其非同源人同种型。

    Immunomodulatory Peptides Derived from Heat Shock Proteins and Uses Thereof
    3.
    发明申请
    Immunomodulatory Peptides Derived from Heat Shock Proteins and Uses Thereof 审中-公开
    源自热休克蛋白的免疫调节肽及其用途

    公开(公告)号：US20080187550A1

    公开(公告)日：2008-08-07

    申请号：US11938762

    申请日：2007-11-12

    申请人： Salvatore Albani ,  Dennis A. Carson ,  Berent J. Prakken ,  Alberto Martini

    发明人： Salvatore Albani ,  Dennis A. Carson ,  Berent J. Prakken ,  Alberto Martini

    IPC分类号： A61K39/00

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K14/4702

    摘要： A method of modulating an immune response in a subject is disclosed. The invention is based on the discovery that an effective therapeutic strategy for ameliorating the inflammation-related symptoms of an immune-mediated disease, such as arthritis, can be achieved by modulation of the underlying immune response itself, rather than by merely addressing the resulting inflammation. This strategy can be used to regulate the inflammatory response and is applicable to a variety of contexts in which immune modulation is desired, such as mucosal tolerization, DNA vaccination, anergy induction, active immunization, and ex vivo modulation of antigen-specific T cells. In one embodiment, the method comprises administering to the subject a bacterial dnaJ peptide or a human homolog or a non-homologous human isoform thereof.

    摘要翻译： 公开了调节受试者的免疫应答的方法。 本发明基于以下发现：通过调节潜在的免疫应答本身而不是仅通过解决所产生的炎症来实现用于改善免疫介导的疾病如关节炎的炎症相关症状的有效治疗策略 。 该策略可用于调节炎症反应，适用于需要进行免疫调节的各种情况，例如粘膜耐受性，DNA疫苗接种，无能力诱导，主动免疫和抗原特异性T细胞的离体调节。 在一个实施方案中，所述方法包括向受试者施用细菌dnaJ肽或人同源物或其非同源人同种型。

    Stress proteins and peptides and methods of use thereof
    7.
    发明申请
    Stress proteins and peptides and methods of use thereof 失效

    公开(公告)号：US20060039918A1

    公开(公告)日：2006-02-23

    申请号：US11080458

    申请日：2005-03-14

    申请人： Salvatore Albani ,  Berent Prakken

    发明人： Salvatore Albani ,  Berent Prakken

    IPC分类号： A61K39/00 ,  C07K14/47

    CPC分类号： C07K14/35 ,  A61K38/00 ,  C07K14/47

    摘要： Provided are HLA pan DR-binding peptides and methods of using such peptides to modulate, block, or inhibit immune responses to effect treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. These peptides and methods are also useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or up-regulate an immune response against aberrant or invading cells, to monitor efficacy for therapeutic treatments, and to identify other agents that may be effective to inhibit or otherwise modulate an immune response such as by altering T cell functional phenotype, and even more particularly by modulating the regulatory phenotype of regulatory T cells and/or inducing emergence of T cells with a different functional phenotype.

    Method of isolating antigen-specific T cells employing artificial antigen presenting cells
    8.
    发明授权
    Method of isolating antigen-specific T cells employing artificial antigen presenting cells 失效
    使用人造抗原呈递细胞分离抗原特异性T细胞的方法

    公开(公告)号：US07807377B2

    公开(公告)日：2010-10-05

    申请号：US10960855

    申请日：2004-10-06

    申请人： Salvatore Albani

    发明人： Salvatore Albani

    IPC分类号： G01N33/53

    CPC分类号： A61K39/00 ,  A61K9/1271 ,  A61K2039/5154 ,  A61K2039/55555 ,  C12N5/0636 ,  Y02A50/472

    摘要： The present invention concerns artificial antigen presenting cells (aAPCs) and methods of making and using the same, for example, to isolate, identify, and expand T cell populations specifically reactive against a disease-associated antigenic peptide, as well as to modulate responses of antigen-specific T cells both in vivo, ex vivo, and in vitro. Accordingly, the aAPCs of the invention can be used to treat conditions that would benefit from modulation of a T cell response, for example, autoimmune disorders, allergies, cancers, viral infections, and graft rejection. In certain preferred embodiments, the aAPCs are liposomes comprised of MHC:peptide complexes and accessory molecules. Other molecules, such as co-stimulatory molecules and adhesion molecules, can also be included in the compositions of the invention. In other embodiments, the aAPCs are comprised of a scaffold to which a plurality of MHC:peptide complexes and accessory molecules (as well as other molecules) can be attached at high density.

    摘要翻译： 本发明涉及人造抗原呈递细胞（aAPC）及其制备和使用方法，例如分离，鉴定和扩增与疾病相关抗原肽特异性反应的T细胞群，以及调节 抗原特异性T细胞在体内，离体和体外。 因此，本发明的aAPCs可用于治疗将受益于调节T细胞应答，例如自身免疫疾病，过敏症，癌症，病毒感染和移植排斥的病症。 在某些优选实施方案中，aAPC是由MHC：肽复合物和辅助分子组成的脂质体。 其他分子，如共刺激分子和粘附分子，也可以包括在本发明的组合物中。 在其它实施方案中，aAPC由多个MHC：肽复合物和辅助分子（以及其它分子）以高密度连接的支架组成。

    Methods for epitope-specific and cytokine/anticytokine combination immunotherapies
    10.
    发明授权
    Methods for epitope-specific and cytokine/anticytokine combination immunotherapies 有权
    表位特异性和细胞因子/抗细胞因子联合免疫治疗方法

    公开(公告)号：US07790158B2

    公开(公告)日：2010-09-07

    申请号：US10490949

    申请日：2002-09-25

    申请人： Salvatore Albani ,  Alberto Martini

    发明人： Salvatore Albani ,  Alberto Martini

    IPC分类号： A61K38/19 ,  A61K39/395

    CPC分类号： A61K38/1793 ,  A61K38/19 ,  A61K39/0008 ,  A61K2039/505 ,  A61K2300/00

    摘要： The current invention provides for methods of immunotherapy using a combination of epitope-specific and cytokine or anticytokine immunotherapy. The method provides for modulation of pathogenic immune responses and includes the identification of molecules comprising specific epitopes involved in a particular disease state of interest, administration of the epitope-specific molecule in conjunction with the cytokine or anticytokine, and downstream modification of the administration of the cytokine/anticytokine relative to the administration of the epitope-specific molecule.

    摘要翻译： 本发明提供了使用表位特异性和细胞因子或抗细胞因子免疫治疗的组合的免疫治疗方法。 该方法提供致病性免疫应答的调节，并且包括鉴定涉及特定疾病状态的特异性表位的分子，与细胞因子或抗细胞因子联合施用表位特异性分子，以及下游修饰 细胞因子/抗细胞因子相对于表位特异性分子的施用。