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    Method For Preparing Substituted Phenylacetic Acid Derivative
    5.
    发明申请
    Method For Preparing Substituted Phenylacetic Acid Derivative 有权

    公开(公告)号：US20210078941A1

    公开(公告)日：2021-03-18

    申请号：US16644205

    申请日：2018-08-07

    申请人： Jiangsu Ruike Medical Science And Technology Co., Ltd.

    发明人： Jieping Li ,  Zhaobo Gao ,  Bing Chai ,  Hui Zheng ,  Shengmin Liu ,  Aqing Liu ,  Bibao Guo ,  Juncheng Zheng ,  Changfa Wang ,  Weiwei Lu

    IPC分类号： C07C253/30 ,  C07C51/38 ,  C07C69/757 ,  C07C67/343 ,  C07C253/14 ,  C07C255/41 ,  C07C51/08 ,  C07C59/225 ,  C07C49/467 ,  C07C45/65

    摘要： The invention belongs to the pharmaceutical manufacturing field, which relates to a novel process for the preparation of substituted phenylacetic acids derivatives, especially relates to the preparation of 2-(4-(2-oxocyclopentyl)phenyl)propanoic acid. The process for the preparation of the precursor form of loxoprofen which use 1,4-di-halobenzyl compounds or disubstituted benzyl compounds as starting material, is through the substitution reaction of cyclopentanone groups or its precursor compounds. Wherein X is halogen, L1 is a suitable leaving group selected from halogen, OH, OMs, OTs, OTf and the like; L2 is a suitable leaving group selected from halogen, CN, OH, —CH2OH, —CHO, CH3NO2, ester group, —NR4R5, OTf, OTs, OMs, —C═CR6, —C≡CR7 and the like, wherein R4, R5, R6, R7 are short chain alkyl groups; Z is cyclopentanone group and its precursor form selected from and the like; R3 is short chain alkyl groups. L3 is a suitable leaving group selected from halogen, OH, OMs, OTs, OTf and the like, or organometallic groups. The invention also include the detailed procedure to convert the precursor compounds of cyclopentanone group to cyclopentanone, followed by the transformation of the precursor compounds of loxoprofen to loxoprofen.

    2-fluoroperfluoroalkylcyclohexene derivatives
    6.
    发明授权
    2-fluoroperfluoroalkylcyclohexene derivatives 失效
    2-氟全氟烷基环己烯衍生物

    公开(公告)号：US5356560A

    公开(公告)日：1994-10-18

    申请号：US109568

    申请日：1993-08-20

    申请人： Volker Reiffenrath ,  Herbert Plach

    发明人： Volker Reiffenrath ,  Herbert Plach

    IPC分类号： C07B61/00 ,  C07C17/20 ,  C07C17/25 ,  C07C23/18 ,  C07C43/12 ,  C07C43/17 ,  C07C43/172 ,  C07C43/192 ,  C07C43/225 ,  C07C49/467 ,  C07C69/63 ,  C07C69/65 ,  C07C69/75 ,  C07C69/76 ,  C07C69/773 ,  C07C255/13 ,  C07C255/14 ,  C07C255/19 ,  C07C255/23 ,  C07D319/06 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  G02F1/13 ,  C09K19/52 ,  C07C23/10 ,  C07C43/20 ,  C07D213/62

    CPC分类号： C09K19/321 ,  C07C23/18 ,  C07C43/172 ,  C07C43/225 ,  C07C49/467 ,  C09K19/3098 ,  C09K19/322 ,  C09K19/3402 ,  C09K19/3441 ,  C07C2101/14 ,  C07C2101/16 ,  C09K2019/3422

    摘要： 2-Fluoroperfluoroalkylcyclohexene derivatives of the formula I ##STR1## where R is an alkyl or alkenyl radical having up to 18 carbon atoms which is unsubstituted or substituted by CN or by at least one halogen and in which one or more non-adjacent CH.sub.2 groups may be replaced by a radical selected from the group consisting of --O--, --S--, --CO--, --O--CO--, --CO--O-- and --C.ident.C--,A.sup.1 and A.sup.2 are each, independently of one another,a) a 1,4-phenylene radical, in which one or two CH groups may be replaced by N,b) a 1,4-cyclohexylene radical, in which one or two non-adjacent CH.sub.2 groups may be replaced by --O-- or --S--,c) a 1,4-cyclohexenylene, piperidine-1,4-diyl, 1,4-bicyclo[2.2.2]octylene or naphthalene-2,6-diyl radical,where the radicals a) and b) may be monosubstituted or polysubstituted by halogen atoms, cyano groups and/or methyl groups,Z.sup.1 and Z.sup.2 are each, independently of one another, --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --C.ident.C--, --CH.dbd.CH--, --OCH.sub.2 --, --CH.sub.2 O-- or a single bond, or one of the radicals Z.sup.1 and Z.sup.2 is alternatively --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.sub.2 CH.sub.2 --,o is 0, 1 or 2, andn is 0-7.The derivatives of the present invention can be used as components of liquid-crystalline media for electro-optical display elements, in particular for matrix liquid-crystal displays.

    摘要翻译： 式I的2-氟全氟烷基环己烯衍生物其中R是具有至多18个碳原子的烷基或烯基，其未被取代或被CN或至少一个卤素取代，并且其中一个或多个不相邻的CH 2基团 可以被选自-O - ， - S-，-CO-，-O-CO-，-CO-O-和-C = C-的基团取代，A1和A2各自独立地为 另一个，a）1,4-亚苯基，其中一个或两个CH基团可被N替代，b）1,4-亚环己基，其中一个或两个不相邻的CH 2基团可被 -O-或-S-，c）1,4-亚环己烯基，哌啶-1,4-二基，1,4-双环[2.2.2]亚辛基或萘-2,6-二基，其中基团a ）和b）可以被卤素原子，氰基和/或甲基单取代或多取代，Z 1和Z 2各自彼此独立地为-CO-O-，-O-CO-， - CH 2 CH 2 - ， - C = C-，-CH = CH-，-OCH 2 - ， - CH 2 O-或单键，或者基团Z 1和Z 2中的一个为 （CH2）4-或-CH = CH-CH2CH2-，o为0,1或2，n为0-7。 本发明的衍生物可以用作电光显示元件的液晶介质的组分，特别是用于基质液晶显示器。