公开(公告)号：US08883188B2

公开(公告)日：2014-11-11

申请号：US11913470

申请日：2006-05-03

申请人： Patricia Yvonne Wilhelmina Dankers ,  Gaby Maria Leonarda Hoorne-Van Gemert ,  Henricus Marie Janssen ,  Egbert Willem Meijer ,  Anton Willem Bosman

发明人： Patricia Yvonne Wilhelmina Dankers ,  Gaby Maria Leonarda Hoorne-Van Gemert ,  Henricus Marie Janssen ,  Egbert Willem Meijer ,  Anton Willem Bosman

IPC分类号： A61F2/02 ,  C08G18/42 ,  C08G18/67 ,  A61L31/06 ,  C08G83/00 ,  C08G18/48 ,  C08G18/73

CPC分类号： A61F2/00 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L29/085 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/224 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2420/06 ,  C08G18/246 ,  C08G18/3848 ,  C08G18/4202 ,  C08G18/4238 ,  C08G18/4277 ,  C08G18/4833 ,  C08G18/672 ,  C08G18/73 ,  C08G18/755 ,  C08G83/008 ,  Y10S623/916 ,  Y10S623/926

摘要： The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or bio medical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.

摘要翻译： 本发明涉及模块化超分子生物可再吸收或生物医学材料，其包含（i）包含至少两个4H-单元的聚合物和（ii）生物活性化合物。 任选地，超分子生物可再吸收或生物医学材料包括生物可再吸收或生物医学聚合物作为调节其性质（机械和生物吸收性质）的第三组分。 超分子生物可吸收或生物医学材料特别适用于生物医学应用，例如药物的控制释放，用于组织工程的材料，用于制造假体或植入物的材料，医学成像技术。

公开(公告)号：US08216657B2

公开(公告)日：2012-07-10

申请号：US12806598

申请日：2010-08-17

申请人： Robert B. Meyer ,  Wilbur N. Meyer

发明人： Robert B. Meyer ,  Wilbur N. Meyer

IPC分类号： B32B3/06

CPC分类号： A61F2/80 ,  Y10S623/901 ,  Y10S623/926 ,  Y10T428/21 ,  Y10T428/214 ,  Y10T428/218 ,  Y10T428/219 ,  Y10T428/22

摘要： A preform for making a prosthetic limb socket includes an injection molded disk of thermoplastics material, and a peripheral portion of the disk is supported by a rigid metal ring. The ring and the peripheral disk portion have an interfitting connection which permits the disk and ring to be heated in an oven. The ring and softened disk are then inverted and stretched downwardly over a positive model of a residual limb while a vacuum is introduced through holes within the model to form a plastic socket which conforms to the model. The interfitting connection may be peripherally spaced studs on the ring and projecting into corresponding holes in the disk or may be an annular rib or arcuate rib sections on the ring which project into an annular recess or arcuate cavities within the disk. After the plastic cools, the ring is separated for reuse.

公开(公告)号：US08088837B2

公开(公告)日：2012-01-03

申请号：US12309435

申请日：2006-11-15

申请人： Alexandr Vasilievich Samkov

发明人： Alexandr Vasilievich Samkov

IPC分类号： A61F2/24 ,  B29C33/40 ,  C08G69/48

CPC分类号： A61F2/2415 ,  A61L27/446 ,  A61L27/50 ,  A61L27/507 ,  B29C39/003 ,  B29L2031/7534 ,  C08G61/122 ,  C08K3/30 ,  C08L77/00 ,  Y10S623/926

摘要： The invention relates to medical technology and could be used in manufacturing artificial cardiac valves having one or more cusps made of a polymer composite. The method for manufacturing a cusp of an artificial cardiac valve, includes the steps of: manufacturing a casting mold, and molding a cusp from a polymer composite comprising 78 to 92% by weight of polyamide and 8 to 22% by weight of radiographic contrast medium dispersed therein. The polymer composite can comprise additionally fine acetylene black in amount of 1 to 2% by weight. The preferred radiographic contrast medium is barium sulphate. In one embodiment of the method, the casting mold is manufactured for the molding size 1 to 5% less than necessary, and the cusp is placed after molding into an anticoagulant solution and matured therein until expanding by 1 to 5%.

摘要翻译： 本发明涉及医疗技术，并且可用于制造具有由聚合物复合材料制成的一个或多个尖端的人造心脏瓣膜。 用于制造人造心脏瓣膜的尖点的方法包括以下步骤：制造铸模，并从聚合物复合材料模制尖端，所述聚合物复合材料包含78至92重量％的聚酰胺和8至22重量％的放射照相造影剂 分散在其中。 聚合物复合材料可以包含1-2重量％的额外的细乙炔黑。 优选的射线照相造影剂是硫酸钡。 在该方法的一个实施方案中，制造模具的成型尺寸比所需的小1至5％，并且将尖端成型成抗凝剂溶液并在其中成熟，直到膨胀1至5％。

公开(公告)号：US20090326094A1

公开(公告)日：2009-12-31

申请号：US12309435

申请日：2006-11-15

申请人： Alexandr Vasilievich Samkov

发明人： Alexandr Vasilievich Samkov

IPC分类号： A61F2/00 ,  B29C33/00

CPC分类号： A61F2/2415 ,  A61L27/446 ,  A61L27/50 ,  A61L27/507 ,  B29C39/003 ,  B29L2031/7534 ,  C08G61/122 ,  C08K3/30 ,  C08L77/00 ,  Y10S623/926

摘要： The invention relates to medical technology and could be used in manufacturing artificial cardiac valves having one or more cusps made of a polymer composite. The method for manufacturing a cusp of an artificial cardiac valve, includes the steps of: manufacturing a casting mold, and molding a cusp from a polymer composite comprising 78 to 92% by weight of polyamide and 8 to 22% by weight of radiographic contrast medium dispersed therein. The polymer composite can comprise additionally fine acetylene black in amount of 1 to 2% by weight. The preferred radiographic contrast medium is barium sulphate. In one embodiment of the method, the casting mold is manufactured for the molding size 1 to 5% less than necessary, and the cusp is placed after molding into an anticoagulant solution and matured therein until expanding by 1 to 5%.

摘要翻译： 本发明涉及医疗技术，并且可用于制造具有由聚合物复合材料制成的一个或多个尖端的人造心脏瓣膜。 用于制造人造心脏瓣膜的尖点的方法包括以下步骤：制造铸模，并从聚合物复合材料模制尖端，所述聚合物复合材料包含78至92重量％的聚酰胺和8至22重量％的放射照相造影剂 分散在其中。 聚合物复合材料可以包含1-2重量％的额外的细乙炔黑。 优选的射线照相造影剂是硫酸钡。 在该方法的一个实施方案中，制造模具的成型尺寸比所需的小1至5％，并且将尖端成型成抗凝剂溶液并在其中成熟，直到膨胀1至5％。

公开(公告)号：US20070233275A1

公开(公告)日：2007-10-04

申请号：US11578971

申请日：2005-04-18

申请人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

发明人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

IPC分类号： A61F2/02

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L2430/32 ,  Y10S623/926 ,  C08L67/04

摘要： Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/ε-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater, 2

摘要翻译： 本发明提供一种人造硬膜，其具有至少两层体内可降解聚合物的层叠结构，其至少一层为基材层，所述基材层由乳酸/乙醇酸/ε-己内酯共聚物形成， 所述共聚物的组分摩尔比为60-85:3-15:10-30摩尔％，所述共聚物的平均链长满足下述表达式（1）至（3）及其制备方法， 当使用这种人造硬脑膜时，不会引起液体渗漏，因为缝合孔的膨胀小，并且其保持其强度的时间段适宜地比自动切口再生所需的时间长一点 2， <？in-line-formula description =“In-line formula”end =“lead”？> 1 < L（GA）<[GA％/（LA％+ GA％+ CL％）] xXx0。 58（2）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> 1 < L（CL）<[CL％/（LA％+ GA％+ CL％）xXx0。 其中L（LA），L（GA）和L（CL）表示乳酸单元的平均链长，58（3）<？ 乙醇酸单元和己内酯单元，LA％，GA％和CL％表示共聚物中乳酸组分，乙醇酸组分己内酯组分的摩尔比，X是共聚物的聚合度。

公开(公告)号：US07060347B2

公开(公告)日：2006-06-13

申请号：US10694937

申请日：2003-10-29

申请人： Sylvia Monsheimer ,  Michael Beyer

发明人： Sylvia Monsheimer ,  Michael Beyer

IPC分类号： B32B25/02 ,  B32B25/10 ,  B32B25/12 ,  B32B25/14 ,  B32B25/16

CPC分类号： B32B25/14 ,  A43B13/10 ,  A43B13/12 ,  A43B17/003 ,  B32B5/08 ,  Y10S623/926 ,  Y10T428/249933 ,  Y10T428/249939 ,  Y10T428/3183 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938

摘要： An anisotropic bending element which contains at least the following layers: I. a reinforcing layer I, which contains a fibrous reinforcing component I with a tensile modulus of elasticity of from 1,800 to 20,000 N/mm2, and II. an elastomeric layer II with a tensile modulus of elasticity of from 2 to 1,300 N/mm2; the component I of the reinforcing layer or layers I and the total amount of elastomer of the layer or layers II having in relation to one another a weight ratio of 1:99 to 40:60 and, in the case of bending about an axis running parallel to the reinforcing layer I, the ratio of the rigidity of the complete bending element in the case of a positive direction of rotation in relation to the rigidity in the case of a negative direction of rotation being 1:1.2 or more. The bending element can be used, for example, as an insert part for sports shoes.

摘要翻译： 至少包含以下层的各向异性弯曲元件：I.含有拉伸弹性模量为1800至20000N / mm 2的纤维增强组分I的增强层I和 二， 拉伸弹性模量为2至1300N / mm 2的弹性体层II; 加强层或层I的组分I和层或层II的弹性体的总量相对于彼此的重量比为1:99至40:60，并且在围绕轴运行的情况下 平行于加强层I的情况下，在正向旋转方向的情况下，完全弯曲元件的刚度相对于在负旋转方向的刚度为1：1.2以上的刚度的比例。 弯曲元件可以用作例如运动鞋的插入部件。

公开(公告)号：US06818018B1

公开(公告)日：2004-11-16

申请号：US09133940

申请日：1998-08-14

申请人： Amarpreet S. Sawhney

发明人： Amarpreet S. Sawhney

IPC分类号： A61F202

CPC分类号： A61L27/52 ,  A61L27/34 ,  A61L31/10 ,  A61L31/145 ,  Y10S623/926

摘要： Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more natural or synthetic components that stabilize the a hydrogel-forming precursor solutions at a deposition site for a period of time sufficient for more resilient chemical crosslinks to form. Methods of using such hydrogels as tissue coatings to prevent postsurgical adhesion formation, as tissue augmentation or luminal occlusion aids, as matrices for carrying cells, drugs or other bioactive species, as tissue sealants or adhesives, and as medical device coatings also are provided.

摘要翻译： 提供通过物理和化学交联方法的组合原位形成水凝胶的组合物和方法，其中物理交联由一种或多种天然或合成成分介导，所述天然或合成成分在沉积位置稳定水凝胶形成前体溶液一段时间 时间足以形成更具弹性的化学交联。 还提供了使用这种水凝胶作为组织涂层来防止术后粘连形成的方法，作为组织增加或管腔闭塞辅助剂，作为用于携带细胞，药物或其它生物活性物质的基质，作为组织密封剂或粘合剂，以及作为医疗装置涂层。

公开(公告)号：US06737447B1

公开(公告)日：2004-05-18

申请号：US09571444

申请日：2000-05-16

申请人： Daniel J. Smith ,  Darrell H. Reneker

发明人： Daniel J. Smith ,  Darrell H. Reneker

IPC分类号： A61L1504

CPC分类号： D01F6/96 ,  A61L15/26 ,  A61L15/44 ,  A61L17/145 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/624 ,  Y10S623/926 ,  Y10S977/89 ,  Y10T428/2998 ,  C08L79/02

摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.

摘要翻译： 用于医疗装置的新型涂层使用线性聚（亚乙基亚胺）二氮烯鎓二醇的纳米纤维提供一氧化氮递送。 线性聚（亚乙基亚胺）二氮烯鎓二硫酸盐以受控的方式将一氧化氮（NO）释放到组织和器官中，以帮助愈合过程并防止损伤组织的损伤。 线性聚（亚乙基亚胺）二氮烯鎓二醇的电纺纳米纤维向医疗装置周围的组织递送治疗水平的NO，同时最小化装置的性质的改变。 由于纳米纤维的每单位质量的小尺寸和大的表面积，纳米纤维涂层提供了更大的每单位质量的表面积，同时使装置的其它性质的变化最小化。

公开(公告)号：US06713583B2

公开(公告)日：2004-03-30

申请号：US09792841

申请日：2001-02-23

申请人： Xiugao Liao ,  Joseph I. Weinschenk, III

发明人： Xiugao Liao ,  Joseph I. Weinschenk, III

IPC分类号： C08F11802

CPC分类号： G02B1/043 ,  A61L27/16 ,  A61L2430/16 ,  Y10S623/926 ,  C08L33/06

摘要： Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

摘要翻译： 眼睛透镜，例如眼内透镜，包括具有衍生自选自丙烯酸酯，甲基丙烯酸酯及其混合物的第一单体组分的第一组分的交联聚合物材料和源自第二组分的第二组分，其量为有效量 作为交联聚合物材料中的交联剂。 交联的聚合物材料具有支链烷基，优选包含在至少一部分第一单体组分中，其量可以有效地降低交联聚合物材料相对于基本相同的交联聚合物材料的粘性 没有支链烷基。

公开(公告)号：US20030031697A1

公开(公告)日：2003-02-13

申请号：US10176203

申请日：2002-06-20

发明人： Stephen J. Chudzik ,  David L. Clapper

IPC分类号： A61K009/14 ,  A61N001/30

CPC分类号： A61K9/1647 ,  A61K9/1641 ,  A61K38/1875 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L27/34 ,  A61L29/085 ,  A61L31/148 ,  Y10S623/92 ,  Y10S623/921 ,  Y10S623/923 ,  Y10S623/926

摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.