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337 条记录 (耗时 0.032 秒)

    Active drug delivery in the gastrointestinal tract
    1.
    发明申请
    Active drug delivery in the gastrointestinal tract 审中-公开
    活动药物在胃肠道输送

    公开(公告)号：US20040267240A1

    公开(公告)日：2004-12-30

    申请号：US10838072

    申请日：2004-05-03

    发明人： Yossi Gross ,  Yoram Sela ,  Ziv Belsky ,  Daniel Goldstein

    IPC分类号： A61N001/30 ,  A61K009/48

    CPC分类号： A61B1/041 ,  A61B5/0008 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/42 ,  A61B5/4839 ,  A61J3/07 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0097 ,  A61M31/002

    摘要： Apparatus for drug administration is provided, including an ingestible capsule, which includes a drug, stored by the capsule, and an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule within a gastrointestinal (GI) tract of a subject. The capsule further includes first and second electrodes, and a control component, adapted to facilitate passage of the drug, in response to a change of state of the environmentally-sensitive mechanism, through an epithelial layer of the GI tract by driving the first and second electrodes to apply a nulllow intensity time-varyingnull (LITV) signal.

    摘要翻译： 提供了用于药物给药的装置，包括可摄入胶囊，其包括由胶囊储存的药物和环境敏感性机构，其适于改变其状态，其响应于胶囊在胃肠（GI） 课程。 胶囊还包括第一和第二电极以及控制部件，其适于响应于环境敏感性机构的状态改变而促进药物通过胃肠道的上皮层，通过驱动第一和第二 电极施加“低强度时变”（LITV）信号。

    Device and method for controlled delivery of active substance into the skin
    2.
    发明申请
    Device and method for controlled delivery of active substance into the skin 失效
    用于将活性物质控制递送到皮肤中的装置和方法

    公开(公告)号：US20040267189A1

    公开(公告)日：2004-12-30

    申请号：US10493386

    申请日：2004-08-25

    发明人： Daniela Mavor ,  Zvi Nitzan ,  Dov Tamarkin ,  Giora Arbel ,  Nurit Harel ,  Yossi Gross

    IPC分类号： A61N001/30

    CPC分类号： A61N1/325 ,  A61N1/044

    摘要： An apparatus for dermal treatment of an active substance having certain physical properties comprising a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode, capable of closing electrical circuit with the skin surface, a power source for providing a current and voltage, connected through a conductive media to the first and second electrode, and means for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.

    摘要翻译： 一种用于真皮处理具有某些物理性质的活性物质的装置，其包括柔性的，可佩戴的贴片，其适合于皮肤表面的轮廓，并具有：第一电极，其适于通过将电流施加到皮肤上而将活性物质传递到皮肤中 皮肤表面，能够与皮肤表面闭合电路的第二电极，用于提供通过导电介质连接到第一和第二电极的电流和电压的电源，以及用于基本上控制活性物质的穿透深度的装置 通过从多个变量中选择至少一个变量。

    Body dressing
    3.
    发明申请
    Body dressing 审中-公开
    身体敷料

    公开(公告)号：US20040253298A1

    公开(公告)日：2004-12-16

    申请号：US10868566

    申请日：2004-06-14

    发明人： Qi Yu

    IPC分类号： A61N001/30 ,  A61L015/00

    CPC分类号： A61L15/18 ,  A61L15/42 ,  A61N1/30

    摘要： A body dressing includes a permeating fluid adapted for applying on a skin surface of treating tissues of a user and an ion carrier which is mixed with the permeating fluid containing positively charged ions for depolarizing negative ions accumulated under the skin surface of the treating tissue around sweat glands of the user. The permeating fluid is adapted for permeating into the treating tissues through the skin surface so as to provide an ion passway between the skin surface in contact with the permeating fluid and the treating tissues so as to enhance the depolarization of the positively charged ions of the ion carrier with the negative ions around the treating tissues of the sweat glands of the user.

    摘要翻译： 身体敷料包括适于施用于使用者的处理组织的皮肤表面的渗透液和离子载体，其与含有带正电荷的离子的渗透液混合，以使积聚在治疗组织的皮肤表面周围的负离子去极化，围绕汗液 用户的腺体 渗透液适于通过皮肤表面渗透到处理组织中，以在与渗透液和处理组织接触的皮肤表面之间提供离子通道，以增强离子的带正电离子的去极化 载体与使用者的汗腺的处理组织周围的负离子。

    Method and apparatus for enhancement of transdermal transport
    4.
    发明申请
    Method and apparatus for enhancement of transdermal transport 有权
    用于增强透皮运输的方法和装置

    公开(公告)号：US20040236268A1

    公开(公告)日：2004-11-25

    申请号：US10792862

    申请日：2004-03-05

    申请人： Sontra Medical, Inc.

    发明人： Samir S. Mitragotri ,  Joseph Kost ,  Scott C. Kellogg ,  Nicholas F. Warner ,  Tuan A. Elstrom

    IPC分类号： A61N001/30

    CPC分类号： A61B5/411 ,  A61B5/14532 ,  A61B5/415 ,  A61B5/418 ,  A61K49/0004 ,  A61M37/0092 ,  A61M2037/0007

    摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.

    摘要翻译： 根据本发明，公开了一种增强透皮转运的方法。 该方法包括通过透化装置增加膜的面积的渗透性的步骤。 膜可以是生物皮肤或合成皮肤。 渗透装置可以是超声产生装置。 物质被运送进入并通过膜的区域。 该物质可以是药物，疫苗或组织液的组分。

    Method and device for electrochemical formation of therapeutic species in vivo
    5.
    发明申请
    Method and device for electrochemical formation of therapeutic species in vivo 有权
    体内治疗物质电化学形成的方法和装置

    公开(公告)号：US20040230225A1

    公开(公告)日：2004-11-18

    申请号：US10477514

    申请日：2003-11-19

    发明人： Avi Penner ,  Eilezer Gileadi

    IPC分类号： A61N001/30

    CPC分类号： A61K47/6957

    摘要： A device and method are provided for spontaneous electrochemical production of therapeutic species, in vivo. An active metal is implanted in the tissue. The metal undergoes corrosion, thus acting as a reducing agent to constituents in the tissue, so as to cause these constituents to form the therapeutic agents.

    Recirculating hyperpolarized gas cells and associated methods of producing optically pumped hyperpolarized gas
    7.
    发明申请
    Recirculating hyperpolarized gas cells and associated methods of producing optically pumped hyperpolarized gas 审中-公开
    循环超极化气体细胞和相关的产生光泵浦超极化气体的方法

    公开(公告)号：US20040184963A1

    公开(公告)日：2004-09-23

    申请号：US10760746

    申请日：2004-01-20

    发明人： Patrick A. Cella

    IPC分类号： B32B005/02 ,  G01N007/00 ,  B32B027/12 ,  G01N033/00 ,  B32B027/04 ,  G01N027/00 ,  G01N021/00 ,  A61N001/30 ,  A61B005/05 ,  F01N003/10 ,  G01N031/00 ,  G01N024/00

    CPC分类号： G01R33/282 ,  Y10T436/24

    摘要： Methods, systems, assemblies, computer program products and devices produce hyperpolarized gas by: (a) heating a target gas in an optical pumping cell, the optical pumping cell having opposing top and bottom portions; (b) polarizing the target gas in the optical pumping cell; (c) directing heated polarized gas to flow out of the top portion of the optical pumping cell to a storage reservoir, the storage reservoir having a temperature that is less than the temperature of the heated target gas flowing out of the optical pumping chamber; and (d) flowing previously polarized gas from the reservoir into the optical pumping cell.

    摘要翻译： 方法，系统，组件，计算机程序产品和设备通过以下方式产生超极化气体：（a）加热光泵浦单元中的目标气体，所述光泵浦单元具有相对的顶部和底部; （b）使光泵浦单元中的目标气体偏振; （c）引导加热的极化气体从光学泵浦单元的顶部部分流出到储存容器，所述储存器的温度小于从所述光学泵送室流出的加热的目标气体的温度; 和（d）将先前偏振的气体从储存器流入光泵浦单元。

    Photodynamic and sonodynamic therapy
    9.
    发明申请
    Photodynamic and sonodynamic therapy 审中-公开
    光动力学和声动力学治疗

    公开(公告)号：US20040171601A1

    公开(公告)日：2004-09-02

    申请号：US10631524

    申请日：2003-07-31

    发明人： Dai Fukumura ,  Dennis E.J.G.J. Dolmans ,  Rakesh K. Jain ,  John S. Hill

    IPC分类号： A61K031/555 ,  A61N001/30

    CPC分类号： A61K31/555 ,  A61K41/0047 ,  A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K41/0076 ,  A61N5/062 ,  A61N7/00

    摘要： The present invention pertains to improved methods for the destruction of undesirable tissue using photodynamic therapy (PDT) and/or sonodynamic therapy (SDT). Such methods include the use of fractionated dosing of the photosensitizer or sonosensitizer to ensure that the sensitizer can be found in various compartments of the tissue and appropriate vasculature prior to the application of activating energy such as electromagnetic radiation or ultrasonic energy.

    摘要翻译： 本发明涉及使用光动力疗法（PDT）和/或超声动力疗法（SDT）来破坏不良组织的改进方法。 这样的方法包括使用光敏剂或超声敏敏剂的分级给药以确保在施加诸如电磁辐射或超声波能量之类的活化能量之前，可以在组织的各个隔室和适当的脉管系统中发现敏化剂。