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公开(公告)号：US09254267B2
公开(公告)日：2016-02-09
申请号：US12218152
申请日：2008-07-11
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
CPC分类号： A61K9/1647 , A61K9/167 , A61K9/2077 , A61K51/1213
摘要： Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
摘要翻译： 提供组合物和方法以通过首先将这种治疗物质分散或溶解在相对疏水的速率调节剂中以形成混合物来控制通过水凝胶释放相对低分子量的治疗物质。 将混合物形成分散在生物可吸收的水凝胶中的微粒，以便以受控的方式释放水溶性治疗剂。 还提供了在治疗系统中使用本发明组合物的方法。
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公开(公告)号：US08512749B2
公开(公告)日：2013-08-20
申请号：US10795132
申请日：2004-03-05
CPC分类号： A61K9/0075 , A61K9/7023 , A61K47/34
摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
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公开(公告)号：US20110142936A1
公开(公告)日：2011-06-16
申请号：US12968527
申请日：2010-12-15
CPC分类号： A61K49/0442 , A61K49/0419 , A61K51/1244 , A61K2123/00 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/145 , A61L31/148 , A61L31/18
摘要： Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
摘要翻译： 可植入材料可用于医源性部位。 应用范围包括用于基准标记的放射性斑块材料。
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公开(公告)号：US20110066183A1
公开(公告)日：2011-03-17
申请号：US12876980
申请日：2010-09-07
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译： 用于密封与血管连通的穿刺的装置包括由冻干的水凝胶或其它材料形成的多孔载体。 插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。 一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。 当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子 穿刺的地方
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5.发明授权Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels 有权使用水凝胶制品的原位水合来密封或增加组织或血管的方法公开(公告)号：US07648713B2
公开(公告)日：2010-01-19
申请号：US10616055
申请日：2003-07-09
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
CPC分类号： A61L33/0064 , A61B17/12022 , A61B17/12099 , A61B17/12104 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B2017/00898 , A61K6/0014 , A61K6/0067 , A61K9/0024 , A61K9/0036 , A61K9/0085 , A61K9/2027 , A61L24/0015 , A61L24/0031 , A61L31/145 , A61L31/16 , A61L2300/418 , A61K6/0035 , C08L39/06 , A61K6/0038 , C08L33/14 , C08L71/02
摘要： Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
摘要翻译： 将天然，重组或合成来源的药学上可接受的水凝胶聚合物或其混合物以干燥，较少水合或基本上脱水状态引入，并在生理环境中再水合以进行体积膨胀并影响密封，堵塞或增加 组织，组织缺陷或器官缺陷。 水凝胶聚合物可以通过在现场的控制释放递送治疗实体。 提供了从这种聚合物形成有用器件和植入器件的方法。
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公开(公告)号：US20080279944A1
公开(公告)日：2008-11-13
申请号：US12218152
申请日：2008-07-11
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
IPC分类号： A61K9/00
CPC分类号： A61K9/1647 , A61K9/167 , A61K9/2077 , A61K51/1213
摘要： Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
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公开(公告)号：US20080220047A1
公开(公告)日：2008-09-11
申请号：US11714028
申请日：2007-03-05
CPC分类号： A61L27/18 , A61K47/183 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2430/38 , C08G65/33324 , C08G2210/00
摘要： Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.
摘要翻译： 本公开的一些方面涉及用于通过形成原位附着于脊柱内部的组织并且基本上位于椎骨柱的外部的组织的低溶胀生物可降解水凝胶来治疗椎骨内的组织的外科治疗。
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公开(公告)号：US07413781B2
公开(公告)日：2008-08-19
申请号：US11644606
申请日：2006-12-22
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
CPC分类号： C12N11/04 , A61K9/1635 , A61K9/1647 , A61K9/5031 , A61K9/5073 , A61K35/30 , A61K35/39 , A61K38/42 , A61K38/44 , A61K47/645 , A61K47/6925 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , C08L71/02
摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.
摘要翻译： 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已被包封的材料上形成。
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公开(公告)号：US07347850B2
公开(公告)日：2008-03-25
申请号：US10319308
申请日：2002-12-13
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
IPC分类号： A61M31/00
CPC分类号： A61K9/0024 , A61B17/00491 , A61B2017/00495 , A61K47/34 , A61L27/18 , A61L27/50 , A61L31/06 , A61M25/0071 , A61M35/00 , C08G63/08 , C08G63/912
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.
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10.发明授权Multiblock biodegradable hydrogels for drug delivery and tissue treatment 有权用于药物递送和组织治疗的多嵌段可生物降解水凝胶公开(公告)号：US07250177B2
公开(公告)日：2007-07-31
申请号：US11158565
申请日：2005-06-22
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。
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