公开(公告)号：US20180000559A1

公开(公告)日：2018-01-04

申请号：US15538227

申请日：2015-12-21

Applicant: Richard Titlebaum ,  Som Tyagi

Inventor： Richard Titlebaum ,  Som Tyagi

IPC: A61C5/50 ,  A61C19/06 ,  A61N5/06 ,  A61K6/00

CPC classification number: A61C5/50 ,  A61C5/40 ,  A61C19/06 ,  A61C2201/002 ,  A61K6/0035 ,  A61N5/062 ,  A61N2005/0606

Abstract: A bactericidal insert for introduction into a canal in a tooth during a root canal procedure is provided, along with a method of producing the insert and a method of using the insert in a root canal procedure. The insert is in the form of a carrier having a plurality of pores or interstices. The carrier had been impregnated with a liquid photosensitive dye so that the dye entered the pores or interstices and then the carrier with the liquid photosensitive dye forms a dye-impregnated carrier. The dye-impregnated carrier is configured and adapted for insertion within the canal of the tooth. The carrier, if dried, is adapted to receive a wetting agent to dissolve the dye therein to produce a liquefied dye, which is activatable to produce singlet oxygen within the canal when it is irradiated by light from outside of the tooth.

公开(公告)号：US20170340523A1

公开(公告)日：2017-11-30

申请号：US15590931

申请日：2017-05-09

Applicant: Essential Dental Systems, Inc.

Inventor： Jason Edward Guzman

IPC: A61K6/06 ,  A61K6/027 ,  A61K6/00 ,  A61K6/087 ,  A61K6/083

CPC classification number: A61K6/0643 ,  A61K6/002 ,  A61K6/0035 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/0276 ,  A61K6/0681 ,  A61K6/083 ,  A61K6/087 ,  C08L33/08

Abstract: Disclosed are biomimetic mineral based endodontic cement compositions. An endodontic cement comprises a paste A and a paste B. The paste A comprises a pozzolanic cementitious mineral paste and the paste B is a mixture comprising polyanionic polymers, phosphates, cement setting modulators, host-inclusion particles, bioactive glasses, and radiopacity agents suspended in a liquid carrier.

公开(公告)号：US20170304157A1

公开(公告)日：2017-10-26

申请号：US15627760

申请日：2017-06-20

Applicant: Amy Dukoff

Inventor： Amy Dukoff

IPC: A61K6/00 ,  A61C5/50 ,  A61C5/40

CPC classification number: A61K6/0035 ,  A61C5/40 ,  A61C5/50 ,  A61K6/0032 ,  A61K6/0041

Abstract: A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and/or ceteareth-20. It is effective against Enterococcus faecalis.

公开(公告)号：US20170056297A1

公开(公告)日：2017-03-02

申请号：US15264364

申请日：2016-09-13

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Anil KISHEN ,  Annie SHRESTHA

IPC: A61K6/00 ,  A61C5/02

CPC classification number: A61K6/0052 ,  A61C5/40 ,  A61C5/55 ,  A61K6/0008 ,  A61K6/0035 ,  A61K6/0038 ,  A61K6/0058 ,  A61K9/5161 ,  A61K41/0057 ,  A61N5/062

Abstract: Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibacterial/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.

Abstract translation: 壳聚糖纳米粒子用于体内治疗根管治疗中的结缔组织。 纳米颗粒任选地与一种或多种可光活化化合物连接以提供抗细菌/抗菌膜性质，中和细菌副产物和/或化学/光动力学交联，以实现增强的机械性能，结缔组织中的化学稳定性和/或改善填充之间的表面/界面完整性 材料和结缔组织。

公开(公告)号：US09399003B2

公开(公告)日：2016-07-26

申请号：US14345161

申请日：2012-09-17

Applicant: Rajdeep S. Pavaskar

Inventor： Rajdeep S. Pavaskar ,  Ida de Noronha de Ataide ,  Paul Chalakkal ,  Nathan de Noronha de Ataide ,  Kristlee Sabrin Fernandes ,  Rahul Wagle ,  Ramchandra Keny ,  Devika Dhond ,  Maria Jose Wiseman Pinto ,  Padmanabh V. Rataboli ,  Anagha J. Kamath

IPC: A61K6/00 ,  A61K31/422

CPC classification number: A61K6/0035 ,  A61K6/0067

Abstract: Disclosed is dental root canal filling (intracanal medicament) compositions that are effective against resistant root canal infections caused by Enterococcus faecalis and Vancomycin-resistant Enterococci.

Abstract translation: 公开了对肠球菌粪肠球菌和耐万古霉素肠球菌引起的耐药性根管感染有效的牙根根管填充（intracanal drug）组合物。

公开(公告)号：US20160067149A1

公开(公告)日：2016-03-10

申请号：US14477682

申请日：2014-09-04

Applicant: Anil Kishen

Inventor： Anil Kishen

IPC: A61K6/00 ,  A61N5/06 ,  A61M37/00 ,  A61C5/04

CPC classification number: A61K6/0035 ,  A61C5/50 ,  A61K6/0017 ,  A61K6/0052 ,  A61M37/0092 ,  A61N5/0603 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0654 ,  A61N2005/067

Abstract: A photo-chemically activated micro-bubble based root canal disinfection method for disinfecting a shaped root canal comprises (a) introducing a photoactive solution into the root canal, the photoactive solution containing a photoactive compound (such as methylene blue) dissolved in an alcohol carrier solution (such as polyethylene glycol and/or ethanol); (b) removing excess photoactive solution from the root canal; (c) introducing a micro-bubble solution comprised of an oxygen carrier (such as perfluorocarbon), an oxidizing agent (such as hydrogen peroxide) and a surfactant (such as a nonionic polyoxyethylene surfactant); (d) sonically or ultrasonically activating the micro-bubble solution in the canal; and (e) introducing light into the canal.

Abstract translation: 用于消毒成形根管的光化学活化的基于微泡的根管消毒方法包括（a）将光敏溶液引入根管中，所述光敏溶液含有溶解在醇载体中的光活性化合物（例如亚甲基蓝） 溶液（如聚乙二醇和/或乙醇）; （b）从根管中除去过量的光敏溶液; （c）引入由氧载体（例如全氟化碳），氧化剂（例如过氧化氢）和表面活性剂（例如非离子聚氧乙烯表面活性剂）组成的微气泡溶液; （d）声波或超声波激活运河中的微泡溶液; 和（e）将光引入运河。

公开(公告)号：US20140335477A1

公开(公告)日：2014-11-13

申请号：US14331813

申请日：2014-07-15

Applicant: Amy Dukoff-Toro

Inventor： Amy Dukoff-Toro

IPC: A61K6/00 ,  A61C5/02

CPC classification number: A61K6/0035 ,  A61C5/40 ,  A61C5/50 ,  A61K6/0032 ,  A61K6/0041

Abstract: A single intra-canal substance composition for tissue dissolution, disinfection, tissue degradation, tissue removal and disinfection is provided. The composition includes calcium hydroxide, sodium hydroxide, potassium thioglycolate or calcium thioglycolate, to form an effective single intra-canal substance capable of degrading a cell by disrupting its disulfide bonds. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, water fragrance, lanolin, and ceteareth-20 to enhance its functioning. Furthermore, the composition that is bactericidal against Enterococcus faecalis, Streptococcus mutans and Candida albicans, used in multiple applications in dentistry and medicine. Furthermore, the composition is a single intra-canal irrigant that eradicates microorganisms as it facilitates the chemo-mechanical debridement of the root canal system.

Abstract translation: 提供了用于组织溶解，消毒，组织降解，组织去除和消毒的单个管内物质组合物。 该组合物包括氢氧化钙，氢氧化钠，巯基乙酸钾或巯基乙酸钙，以形成能够通过破坏其二硫键而使细胞降解的有效的单一管内物质。 此外，组合物可以包含矿物油，尿素，鲸蜡硬脂醇，D＆C黄色8号，氢氧化铬，可可可可种子黄油，氧化铁，香料，水香料，羊毛脂和鲸蜡硬脂醇聚醚-20，以增强其功能。 此外，对粪肠球菌，变形链球菌和白色念珠菌具有杀菌性的组合物，用于牙科和医学中的多种应用。 此外，组合物是消除微生物的单一的渠内冲洗剂，因为它有助于根管系统的化学机械清创。

公开(公告)号：US08865791B2

公开(公告)日：2014-10-21

申请号：US13499902

申请日：2011-11-14

Applicant: Gilles Richard ,  Olivier Marie

Inventor： Gilles Richard ,  Olivier Marie

IPC: A61K6/08 ,  A61K6/083 ,  A61C5/02 ,  A61C5/04 ,  A61K6/00 ,  A61K6/06

CPC classification number: A61K6/0073 ,  A61K6/0091 ,  A61K6/0625 ,  A61K6/0668 ,  A61K6/0675 ,  A61K6/0681 ,  A61K6/0038 ,  C08L29/04 ,  C08L31/04 ,  C08L33/08 ,  C08L33/10 ,  C08L33/14 ,  C08L5/04 ,  C08L83/04 ,  C08L23/20 ,  C08L7/00 ,  A61K6/0835 ,  C08L39/06 ,  A61K6/0035

Abstract: This invention relates to a composition resulting from the mixture of a solid phase, comprising at least one calcium derivative powder in association with at least one radioopacifier and at least one polymer and optionally at least one non-radioopaque filler, all in powder form; and aqueous phase comprising water, at least one water-reducing agent, and at least one set accelerator; the ratio of solid phase to liquid phase ranging from 1.0 to 2.5, preferably from 1.5 to 2.2, more preferably from 2 to 2.15; said composition having a compressive strength of less than 40 MPa, preferably ranging from 1 to 15 MPa, preferably ranging from about 3 to about 12 MPa; this invention also relates to a kit and a method for the manufacture of the composition, and to a method for treating or retreating a canal root.

Abstract translation: 本发明涉及一种由固相混合物组成的组合物，所述组合物包含至少一种与至少一种放射性光聚合剂结合的钙衍生物粉末和至少一种粉末形式的聚合物和任选的至少一种非放射性不透性填料; 和含有水，至少一种减水剂和至少一种凝固促进剂的水相; 固相与液相的比例为1.0至2.5，优选为1.5至2.2，更优选为2至2.15; 所述组合物的抗压强度小于40MPa，优选为1至15MPa，优选为约3至约12MPa; 本发明还涉及一种用于制备组合物的试剂盒和方法，以及用于治疗或后退管根的方法。

公开(公告)号：US08808718B2

公开(公告)日：2014-08-19

申请号：US13579577

申请日：2011-02-18

Applicant: Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

Inventor： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

IPC: A61K8/02 ,  A61K47/26 ,  A61K9/00 ,  A61K6/00 ,  A61K47/12

CPC classification number: A61K9/006 ,  A61K6/0035 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.

Abstract translation: 本发明涉及用于牙科治疗的消毒剂或抗微生物组合物，例如治疗和/或预防牙周炎，牙龈炎或其它形式的口腔感染。 本发明人发现感染牙科组织并引起其炎症的微生物易渗透压力，使得高渗组合物的施用有效地治愈或预防感染和/或炎症。 此外，还发现这些微生物也易受酸性胁迫。 因此，本发明提供了当在局部施用于其上时诱导牙科组织感染的微生物诱导渗透胁迫的组合物，优选渗透性和酸性应激。 本发明还涉及涉及本发明组合物的方法和用途。

公开(公告)号：US20140107214A1

公开(公告)日：2014-04-17

申请号：US14135226

申请日：2013-12-19

Applicant: The University of British Columbia

Inventor： Markus Haapasalo

IPC: A61K6/00 ,  A61Q11/00

CPC classification number: A61K6/0035 ,  A61K9/0063 ,  A61K31/14 ,  A61K31/155 ,  A61K31/198 ,  A61Q11/00 ,  A61K2300/00

Abstract: Composition and method for irrigating a prepared dental root canal. The composition is an aqueous composition of ethylenediaminetetraacetic acid, chlorhexidine or orally acceptable addition salt, and N-cetyl-N,N,N-trimethylammonium bromide, and is effective for simultaneous smear layer removal and disinfection.

Abstract translation: 用于冲洗准备好的牙根管的组合物和方法。 该组合物是乙二胺四乙酸，洗必太或口服可接受的加成盐和N-十六烷基-N，N，N-三甲基溴化铵的水性组合物，并且对于同时涂抹层去除和消毒是有效的。