公开(公告)号：US20170304157A1

公开(公告)日：2017-10-26

申请号：US15627760

申请日：2017-06-20

Applicant: Amy Dukoff

Inventor： Amy Dukoff

IPC: A61K6/00 ,  A61C5/50 ,  A61C5/40

CPC classification number: A61K6/0035 ,  A61C5/40 ,  A61C5/50 ,  A61K6/0032 ,  A61K6/0041

Abstract: A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and/or ceteareth-20. It is effective against Enterococcus faecalis.

公开(公告)号：US20160100912A1

公开(公告)日：2016-04-14

申请号：US14882017

申请日：2015-10-13

Applicant: Todd Geisler ,  Graham Geisler ,  Jamison Geisler

Inventor： Todd Geisler ,  Graham Geisler ,  Jamison Geisler

IPC: A61C5/04 ,  A61K6/00 ,  A61C5/06

CPC classification number: A61C13/0006 ,  A61C5/50 ,  A61C5/62 ,  A61K6/0032 ,  A61K6/0067 ,  A61K9/0024 ,  A61K35/19 ,  A61K38/363 ,  A61L27/225 ,  A61L27/3616 ,  A61L2430/12

Abstract: Devices, methods, inserts, and systems useful in endodontic treatments, involving, for example, a shaped regenerative endodontic insert that contains platelet-fibrin matrix; certain shaped insert embodiments are formed by molding in a cavity mold, optionally as part of a mold assembly.

Abstract translation: 用于牙髓治疗的装置，方法，插入物和系统，涉及例如包含血小板 - 纤维蛋白基质的成形再生牙髓根管插入物; 某些成型的插入物实施例通过模制在空腔模具中，可选地作为模具组件的一部分而形成。

公开(公告)号：US20150328236A1

公开(公告)日：2015-11-19

申请号：US14440137

申请日：2013-11-01

Applicant: OZDENT PTY LTD

Inventor： Joshua George TADROS

IPC: A61K31/65 ,  A61K9/00 ,  A61K47/02 ,  A61K47/18 ,  A61K31/58 ,  A61K47/10

CPC classification number: A61K31/65 ,  A61K6/0032 ,  A61K6/0041 ,  A61K9/0053 ,  A61K31/573 ,  A61K31/58 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K2300/00

Abstract: A dental composition comprising a therapeutically effective amount of doxycycline hyclate and a therapeutically effective amount of triamcinolone acetonide and use in dental treatment.

Abstract translation: 一种牙科用组合物，其包含治疗有效量的多西环素hyclate和治疗有效量的曲安奈德，并用于牙科治疗。

公开(公告)号：US20140335477A1

公开(公告)日：2014-11-13

申请号：US14331813

申请日：2014-07-15

Applicant: Amy Dukoff-Toro

Inventor： Amy Dukoff-Toro

IPC: A61K6/00 ,  A61C5/02

CPC classification number: A61K6/0035 ,  A61C5/40 ,  A61C5/50 ,  A61K6/0032 ,  A61K6/0041

Abstract: A single intra-canal substance composition for tissue dissolution, disinfection, tissue degradation, tissue removal and disinfection is provided. The composition includes calcium hydroxide, sodium hydroxide, potassium thioglycolate or calcium thioglycolate, to form an effective single intra-canal substance capable of degrading a cell by disrupting its disulfide bonds. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, water fragrance, lanolin, and ceteareth-20 to enhance its functioning. Furthermore, the composition that is bactericidal against Enterococcus faecalis, Streptococcus mutans and Candida albicans, used in multiple applications in dentistry and medicine. Furthermore, the composition is a single intra-canal irrigant that eradicates microorganisms as it facilitates the chemo-mechanical debridement of the root canal system.

Abstract translation: 提供了用于组织溶解，消毒，组织降解，组织去除和消毒的单个管内物质组合物。 该组合物包括氢氧化钙，氢氧化钠，巯基乙酸钾或巯基乙酸钙，以形成能够通过破坏其二硫键而使细胞降解的有效的单一管内物质。 此外，组合物可以包含矿物油，尿素，鲸蜡硬脂醇，D＆C黄色8号，氢氧化铬，可可可可种子黄油，氧化铁，香料，水香料，羊毛脂和鲸蜡硬脂醇聚醚-20，以增强其功能。 此外，对粪肠球菌，变形链球菌和白色念珠菌具有杀菌性的组合物，用于牙科和医学中的多种应用。 此外，组合物是消除微生物的单一的渠内冲洗剂，因为它有助于根管系统的化学机械清创。

公开(公告)号：US20120012030A1

公开(公告)日：2012-01-19

申请号：US13211880

申请日：2011-08-17

Applicant: Mohammad Ali Saghiri ,  Mehrdad Lotfi ,  Houtan Aghili

Inventor： Mohammad Ali Saghiri ,  Mehrdad Lotfi ,  Houtan Aghili

IPC: A61K6/06 ,  B82Y30/00

CPC classification number: B82Y30/00 ,  A61K6/0032 ,  A61K6/0044 ,  A61K6/0612 ,  A61K6/0625 ,  A61K6/0656

Abstract: Disclosed is a dental cement composition made up of ingredients comprising the nanoparticles of dicalcium and tricalcium silicate, bismuth oxide, gypsum, zeolite and strontium carbonate. The dental cement can also be used as bone cement, pulpotomy agent, pulp capping material, dental implant material, perforation repair material, and root-end filling material.

Abstract translation: 公开了由包含二钙和硅酸三钙，氧化铋，石膏，沸石和碳酸锶的纳米颗粒的成分组成的牙科水泥组合物。 牙科水泥也可以用作骨水泥，打浆剂，纸浆覆盖材料，牙科植入材料，穿孔修复材料和根端填充材料。

公开(公告)号：US20110020310A1

公开(公告)日：2011-01-27

申请号：US12922097

申请日：2009-03-12

Applicant: Misako Nakashima ,  Koichiro Iohara

Inventor： Misako Nakashima ,  Koichiro Iohara

IPC: A61K35/12 ,  A61P1/02

CPC classification number: A61L27/3834 ,  A61K6/0032 ,  A61L27/3633 ,  A61L27/3865 ,  A61L2400/06 ,  A61L2430/12

Abstract: Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler (200) having an extracellular matrix (210) containing the cells (220) enriched for dental pulp stem cells, is inserted into the apical side of the root canal of a target tooth (100). The cells including dental pulp stem cells include at least one of the following: dental pulp SP cells, CD31-negative and CD146-negative cells, CD24-positive cells, CD105-positive cells, and CD150-positive cells. For instance, dental pulp SP cells are CD31− and CD146− negative. Even if pulpitis due to deep caries occurs, appropriate dental pulp regeneration and recovery of dental pulp function are possible.

Abstract translation: 提供了一种新颖创新的牙科组织再生方法，用于在切除术后进行牙齿组织再生或扩大和清洁受感染的根管。 在进行切割或扩大和清洁感染的根管之后，将含有富含牙髓干细胞的细胞（220）的细胞外基质（210）的根管填料（200）插入到根管的顶端 的目标牙齿（100）。 包括牙髓干细胞的细胞包括以下至少一种：牙髓SP细胞，CD31阴性和CD146阴性细胞，CD24阳性细胞，CD105阳性细胞和CD150阳性细胞。 例如，牙髓SP细胞是CD31-和CD146-阴性的。 即使发生由于深度龋齿引起的牙髓炎，也可以适当地进行牙髓再生和恢复牙髓功能。

公开(公告)号：US20100203481A1

公开(公告)日：2010-08-12

申请号：US12670017

申请日：2008-12-12

Applicant: Peter E. Murray ,  Franklin Garcia-Godoy

Inventor： Peter E. Murray ,  Franklin Garcia-Godoy

IPC: A61C19/06 ,  B65D69/00

CPC classification number: A61K6/0032 ,  A61C5/50

Abstract: The present invention provides novel methods and kits for removing unhealthy or necrotic pulp tissue from inside the root canals of a tooth, and to replace it with new vascularized tissue created by regenerative endodontic treatment. The present invention provides alternatives to current root canal therapies, as well as obturation of the root canal with dental materials.

Abstract translation: 本发明提供了用于从牙根的根管内去除不健康或坏死牙髓组织的新方法和试剂盒，并且用再生牙髓治疗产生的新的血管化组织代替它。 本发明提供了当前根管治疗的替代方案，以及牙根材料对根管的封闭。

公开(公告)号：US07700133B2

公开(公告)日：2010-04-20

申请号：US10597486

申请日：2005-02-17

Applicant: Marianna Cooley ,  Timothy W. Fraser

Inventor： Marianna Cooley ,  Timothy W. Fraser

IPC: A61K33/00 ,  A61P31/00 ,  A61Q11/00 ,  A61K6/00 ,  A61K33/24 ,  A61K33/08 ,  A61K33/16 ,  A61K33/22 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K33/42

CPC classification number: A01L15/00 ,  A61K6/0017 ,  A61K6/0032 ,  A61K6/06 ,  A61K33/00 ,  A61K33/08 ,  A61K33/22 ,  A61K33/24 ,  A61K33/245 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06

Abstract: Formulations and blends are described comprising zinc, silver, bismuth and copper in non-toxic amounts that are useful as treatments of a wide variety of conditions and diseases promoted by bacteria or other microorganisms.

Abstract translation: 描述的制剂和共混物包括无毒量的锌，银，铋和铜，其可用作由细菌或其他微生物促进的各种各样的条件和疾病的治疗。

公开(公告)号：US20070151485A1

公开(公告)日：2007-07-05

申请号：US11567849

申请日：2006-12-07

Applicant: Leif Hermansson ,  Hakan Engqvist

Inventor： Leif Hermansson ,  Hakan Engqvist

IPC: C04B28/06

CPC classification number: C04B28/06 ,  A61K6/0032 ,  A61K6/0612 ,  A61K6/0631 ,  A61L24/02 ,  A61L24/12 ,  C04B28/342 ,  C04B2103/0067 ,  C04B2111/00836 ,  C04B7/32 ,  C04B14/04 ,  C04B22/126 ,  C04B22/106

Abstract: The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.

Abstract translation: 本发明涉及高碱性化学键合的陶瓷体系如铝酸钙和Ca-硅酸盐的初始水合反应，其表现出受控的pH发展，通过使用从非常高的水平降低到pH范围7-9 的内部缓冲系统添加到使用的CBC型生物材料。 本发明特别适用于牙根管，矫形应用和/或软组织应用和/或药物递送载体应用。

公开(公告)号：US20070040151A1

公开(公告)日：2007-02-22

申请号：US11483488

申请日：2006-07-10

Applicant: Andreas Utterodt ,  Heike Hennen

Inventor： Andreas Utterodt ,  Heike Hennen

IPC: C09K3/00

CPC classification number: C08F4/40 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0032 ,  A61K6/083 ,  A61K6/09 ,  C08L33/00 ,  C08L75/16

Abstract: A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.

Abstract translation: 一种具有用于固化可聚合材料的促进剂的双组分引发剂体系，其包含以下组分：（a）含有一个或多个与叔碳键合的氢过氧化物基团的氢过氧化物化合物; （b）硫脲衍生物; 和（c）作为促进剂，可溶于制剂的铜化合物优选不含胺，特别适用于可聚合牙科组合物。