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公开(公告)号：US20130236517A1
公开(公告)日：2013-09-12
申请号：US13885807
申请日：2011-11-16
Applicant: Leif Hermansson , Fredrik Alpsten
Inventor： Leif Hermansson , Fredrik Alpsten
CPC classification number: A61L24/02 , A61K6/033 , A61K6/0637 , A61K6/0643 , A61L24/001 , C04B28/06 , C04B28/186 , C04B2111/00836 , C04B22/126 , C04B24/24
Abstract: The present invention relates to chemically bonded ceramic biomaterials, especially a dental material or an implant material. The main binder system forms a chemically bonded ceramic upon hydration thereof, and comprises powdered calcium aluminate and/or calcium silicate, and phase(s) to secure apatite formation at a pH close to neutrality. A second binder system—a cross-linking organic binder system which provides for initial crosslinking of the freshly mixed paste is advantageously added. The invention relates to a powdered composition for preparing the inventive chemically bonded ceramic biomaterial, and a paste from which the biomaterial is formed, as well as a kit comprising the powdered composition and hydration liquid, as well as methods and use of the biomaterial in dental and implant applications with the aim of remineralisation, integration and bone repair.
Abstract translation: 本发明涉及化学结合的陶瓷生物材料，特别是牙科材料或植入材料。 主要的粘合剂体系在其水合时形成化学键合的陶瓷，并且包含粉末状的铝酸钙和/或硅酸钙，以及在接近中性的pH下确保磷灰石形成的相。 有利地加入第二粘合剂体系 - 交联有机粘合剂体系，其提供新混合糊料的初始交联。 本发明涉及用于制备本发明化学结合的陶瓷生物材料的粉末组合物，以及形成生物材料的糊料，以及包含粉末状组合物和水合液体的试剂盒，以及牙科中生物材料的方法和用途 和植入应用，目的是再矿化，整合和骨修复。
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2.发明授权Dental cement system, a powdered material and a hydration liquid therefor, and ceramic material formed therefrom 有权牙科水泥系统，粉末材料及其水合液体，以及由其形成的陶瓷材料公开(公告)号：US07867329B2
公开(公告)日：2011-01-11
申请号：US11895232
申请日：2007-08-23
Applicant: Leif Hermansson , Jesper Lööf , Håkan Engqvist
Inventor： Leif Hermansson , Jesper Lööf , Håkan Engqvist
IPC: C04B7/32
CPC classification number: C04B28/06 , A61K6/0008 , A61K6/0091 , A61K6/0631 , A61K6/0675 , A61L24/02 , C04B2111/00836 , C04B14/043 , C04B20/008 , C04B22/124 , C04B22/126 , C04B24/06 , C04B24/2641 , C04B2103/0086 , A61K6/0835 , C08L33/08 , C08L69/00
Abstract: A dental cement system, including an aqueous hydration liquid and a powdered material that essentially consists of an inorganic cement system, which powdered material has the capacity to form a complex, chemically bonded material with inorganic as well as organic phases with properties suitable for cementation of implant to another implant and/or to tooth or bone tissue.
Abstract translation: 一种牙科水泥系统，包括水性水合液体和基本上由无机水泥体系组成的粉末材料，该粉末材料具有与无机和有机相形成复合化学键合的材料的能力，其特性适合于粘合 植入到另一植入物和/或牙齿或骨组织。
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3.发明授权System for a dental filling material or implant material, and powdered material, hydration liquid, implant material and method of achieving bonding 有权用于牙科填充材料或植入材料的系统，以及粉末材料，水合液体，植入材料和实现结合的方法公开(公告)号：US07699925B2
公开(公告)日：2010-04-20
申请号：US10518084
申请日：2003-06-11
Applicant: Håkan Engqvist , Leif Hermansson , Nils-Otto Ahnfelt , Jesper Loof , Lars Kraft , Jan-Erik Schulz-Walz
Inventor： Håkan Engqvist , Leif Hermansson , Nils-Otto Ahnfelt , Jesper Loof , Lars Kraft , Jan-Erik Schulz-Walz
CPC classification number: A61K6/033 , A61K6/0612 , A61K6/0643 , C04B28/34 , C04B2111/00836 , C04B7/32 , C04B14/06 , C04B14/366 , C04B20/008 , C04B22/064 , C04B22/10 , C04B24/14 , C04B40/06 , C04B14/303 , C04B22/062 , C04B22/0093 , C04B2103/0094
Abstract: A system for a dental filling material or an implant material, alternatively a system for bonding between a tooth or a bone and a dental filling material and a implant material, respectively, which system comprises a water based hydration liquid and a powdered material, the binder phase of which powdered material essentially consisting of a calcium based cement system, which powdered material has the capacity following saturation with the liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, said powdered material and/or said hydration liquid comprises water soluble phosphate or a phase that has the capacity to form water soluble phosphate, whereby the system exhibits the capacity during hydration to form apatite. The invention also relates to the powdered material and the hydration liquid as such, an implant material and a method of achieving bonding.
Abstract translation: 用于牙科填充材料或植入物材料的系统，或者分别用于在牙齿或骨骼和牙齿填充材料和植入物材料之间结合的系统，所述系统包括水基水化液体和粉末材料，所述粘合剂 其粉末材料基本上由钙基水泥系统组成，该粉末材料具有随着与粘合剂相反应的液体饱和的能力以水合化为化学键合的陶瓷材料。 根据本发明，所述粉末材料和/或所述水合液体包括水溶性磷酸盐或具有形成水溶性磷酸盐的能力的相，由此该体系在水合期间显示形成磷灰石的能力。 本发明还涉及粉末材料和水合液体，植入材料和实现结合的方法。
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公开(公告)号：US07682445B2
公开(公告)日：2010-03-23
申请号：US11567849
申请日：2006-12-07
Applicant: Leif Hermansson , Håkan Engqvist
Inventor： Leif Hermansson , Håkan Engqvist
IPC: C04B7/00 , C04B7/34 , C04B24/34 , C04B12/02 , C04B28/34 , C04B7/32 , C04B7/36 , C09K3/00 , A01N59/06 , A61F2/28
CPC classification number: C04B28/06 , A61K6/0032 , A61K6/0612 , A61K6/0631 , A61L24/02 , A61L24/12 , C04B28/342 , C04B2103/0067 , C04B2111/00836 , C04B7/32 , C04B14/04 , C04B22/126 , C04B22/106
Abstract: The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.
Abstract translation: 本发明涉及高碱性化学键合的陶瓷体系如铝酸钙和Ca-硅酸盐的初始水合反应，其表现出受控的pH发展，通过使用从非常高的水平降低到pH范围7-9 的内部缓冲系统添加到使用的CBC型生物材料。 本发明特别适用于牙根管，矫形应用和/或软组织应用和/或药物递送载体应用。
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公开(公告)号：US07501018B2
公开(公告)日：2009-03-10
申请号：US10533380
申请日：2003-12-30
Applicant: Hakan Engqvist , Leif Hermansson
Inventor： Hakan Engqvist , Leif Hermansson
IPC: A61K6/06
CPC classification number: A61K6/033 , A61K6/0038 , A61K6/083 , C04B28/06 , C04B28/18 , C04B28/34 , C04B2111/00198 , C04B2111/00836 , C04B14/22 , C04B14/303 , C04B14/304 , C04B14/366 , C04B24/2641 , C04B24/286
Abstract: A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved translucency. An algorithm to describe the micro-structure is expressed as λ = d * ( 1 - V F ) ( V F ) where λ is the distance between filler particles of mean size d, and VF is the volume content of non-reacted cement and added filler, and where λ≦10 μm. The invention also relates to a device in connection with the preparation of a chemically bonded biomaterial element according to the invention.
Abstract translation: 由无机水泥组成的化学键合的生物材料元素，在硬化和长时间使用时表现出最小的尺寸变化，改善的机械性能和改善的半透明度。 描述微结构的算法表示为
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Patent Agency Ranking
公开(公告)号：US20070232704A1
公开(公告)日：2007-10-04
申请号：US11762370
申请日：2007-06-13
Applicant: Niklas AXEN , Leif HERMANSSON , Dan MARKUSSON , Tobias PERSSON
Inventor： Niklas AXEN , Leif HERMANSSON , Dan MARKUSSON , Tobias PERSSON
IPC: A61K47/02
CPC classification number: A61L27/10
Abstract: The present invention pertains to injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects. The present invention can also be used to restore the mechanical properties of the skeleton after cancerous diseases.
Abstract translation: 本发明涉及基于水硬性铝酸钙的可注射发热生物相容性陶瓷组合物，其可以在体内固化时用于体内治疗性治疗，例如肿瘤治疗，疼痛控制，血管治疗，药物活化等，以及哪种形式 一种生物相容的固体材料，可以长时间放置在体内，不会对健康造成负面影响。 本发明也可用于恢复癌性疾病后骨架的机械性质。
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公开(公告)号：US20060156959A1
公开(公告)日：2006-07-20
申请号：US10533380
申请日：2003-12-30
Applicant: Hakan Engqvist , Leif Hermansson
Inventor： Hakan Engqvist , Leif Hermansson
IPC: C04B35/03
CPC classification number: A61K6/033 , A61K6/0038 , A61K6/083 , C04B28/06 , C04B28/18 , C04B28/34 , C04B2111/00198 , C04B2111/00836 , C04B14/22 , C04B14/303 , C04B14/304 , C04B14/366 , C04B24/2641 , C04B24/286
Abstract: A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved translucency. An algorithm to describe the micro-structure is expressed as λ = d * ( 1 - V F ) ( V F ) where λ is the distance between filler particles of mean size d, and VF is the volume content of non-reacted cement and added filler, and where λ≦10 μm. The invention also relates to a device in connection with the preparation of a chemically bonded biomaterial element according to the invention.
Abstract translation: 由无机水泥组成的化学键合的生物材料元素，在硬化和长时间使用时表现出最小的尺寸变化，改善的机械性能和改善的半透明度。 描述微结构的算法表示为
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8.发明授权Method of making structured ceramic coatings and coated devices prepared with the method 有权用该方法制备结构化陶瓷涂层和涂层装置的方法公开(公告)号：US07048792B2
公开(公告)日：2006-05-23
申请号：US10691542
申请日：2003-10-24
Applicant: Niklas Axen , Kajsa Bjorklund , Leif Hermansson , Hakan Engqvist
Inventor： Niklas Axen , Kajsa Bjorklund , Leif Hermansson , Hakan Engqvist
CPC classification number: A61L27/32 , A61L2420/02 , C23C4/02 , C23C26/00 , C23C28/048 , C23C30/00 , Y10T428/25
Abstract: The invention describes a low temperature method for producing multi-layered or multi-phased coatings. With the technique according to the present invention, surface coatings with controlled variations in terms of chemical composition, phase composition, porosity, surface roughness, mechanical properties, biocompatibility, etc can be achieved. The method of coating a substrate surface comprising the steps of preparing one powder mixture, or several powder mixtures having different chemical composition, wherein at least one of said powder mixtures comprise a non-hydrated hydraulic ceramic powder binder phase, pre-treating a substrate surface, to increase the adhesion between the substrate and the ceramic coating, applying one or more different layers on top of each other of the non-hydrated powder mixture on the substrate, and finally, hydrating the powder layer/layers in a curing agent containing ions of carbonates, phosphates or fluorides.
Abstract translation: 本发明描述了用于生产多层或多相涂层的低温方法。 根据本发明的技术，可以实现在化学成分，相组成，孔隙率，表面粗糙度，机械性能，生物相容性等方面受控变化的表面涂层。 涂覆基材表面的方法包括制备一种粉末混合物或具有不同化学组成的几种粉末混合物的步骤，其中至少一种所述粉末混合物包含非水合水硬性陶瓷粉末粘合剂相，预处理基材表面 ，以增加基底和陶瓷涂层之间的粘合力，在基底上施加一个或多个不同层的非水合粉末混合物的顶部，最后使含有离子的固化剂中的粉末层/层水合 的碳酸盐，磷酸盐或氟化物。
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公开(公告)号：US06969424B2
公开(公告)日：2005-11-29
申请号：US10240502
申请日：2001-04-09
Applicant: Leif Hermansson , Lars Kraft , Bjarne Kjaerstad , Daniel Hermansson
Inventor： Leif Hermansson , Lars Kraft , Bjarne Kjaerstad , Daniel Hermansson
IPC: A61K6/06 , B28C7/06 , C04B7/32 , C04B14/06 , C04B14/30 , C04B24/06 , C04B28/06 , C04B103/40 , C04B111/32
CPC classification number: A61K6/0675 , A61K6/0008 , A61K6/0088 , A61K6/0235 , A61K6/024 , A61K6/0255 , A61K6/0606 , A61K6/0631 , C04B28/06 , C04B2111/00836 , C04B2111/00844 , C04B7/02 , C04B14/062 , C04B14/301 , C04B40/006 , C04B41/53 , C04B2103/10 , C04B2103/302 , C04B20/0036
Abstract: Method for the production of a chemically bound ceramic material by means of reaction between a binding phase of one or more powdered binding agents and a liquid reacting with these binding agents, a quantity of powder containing said binding phase being suspended in said liquid so that all powder grains are brought into close contact with the liquid, whereupon the slurry thus obtained is drained so that the majority of surplus reacting liquid is removed, and is compacted during final draining, before the material is permitted to harden by reaction between said binding phase and the remaining liquid. One or more expansion-compensating additives, adapted to give the material dimensionally stable long-term properties, are mixed into said powder, prior to or in conjunction with its suspension in the liquid. The invention also relates to the product of the method.
Abstract translation: 通过一种或多种粉末结合剂的结合相与与这些粘合剂反应的液体之间的反应生成化学结合的陶瓷材料的方法，将含有所述结合相的一定量的粉末悬浮在所述液体中，使得全部 使粉末颗粒与液体紧密接触，由此排出如此获得的浆料，使得大部分过剩反应液体被除去，并且在最终排液期间被压实，在材料被允许通过所述结合相和 剩余液体。 适于将材料尺寸稳定的长期性能的一种或多种膨胀补偿添加剂在其悬浮液中或与液体中的悬浮液混合之前混入所述粉末中。 本发明还涉及该方法的产物。
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公开(公告)号：US5306673A
公开(公告)日：1994-04-26
申请号：US752605
申请日：1991-08-15
Applicant: Leif Hermansson , Sevald Forberg , Li Jiangou
Inventor： Leif Hermansson , Sevald Forberg , Li Jiangou
IPC: A61K6/033 , A61L27/00 , A61L27/42 , C04B35/10 , C04B35/117 , C04B35/119 , C04B35/447 , C04B35/46 , C04B35/48 , C04B35/488 , C04B35/49 , C04B35/63 , C04B35/645
CPC classification number: A61L27/427 , C04B35/117 , C04B35/119 , C04B35/46 , C04B35/488 , C04B35/49 , C04B35/6313 , C04B35/6455
Abstract: The present invention relates to a method to manufacture a composite ceramic material having a high strength combined with bioactive properties, when the material is used as a dental or orthopedic implant, which includes preparing a powder mixture, mainly comprising partly a first powder, which in its used chemical state will constitute a bioinert matrix in the finished material , and partly a second powder, mainly comprising a calcium phosphate-based material. The invention is characterized in that said first powder comprises at least one of the oxides belonging to the group consisting of titanium dioxide (TiO.sub.2), zirconium oxide (ZrO.sub.2) and aluminum oxide (Al.sub.2 O.sub.3), in that said second powder mainly comprises at least one of the compounds hydroxylapatite and tricalcium phosphate, in that a raw compact is made of said powder mixture and in that said raw compact is densified through an isostatic pressing in a hot condition (HIP) at a pressure higher than 50 MPa, a composite material being obtained, in which said matrix comprises one or several metal oxides of said first powder, in which matrix said compound hydroxylapatite and/or tricalcium phosphate is evenly dispersed.The invention also relates to a composite ceramic material as well as a body, completely or partially made of this material.
Abstract translation: PCT No.PCT / SE90 / 00207 Sec。 371日期1991年8月15日 102（e）1991年8月15日PCT 1990年3月30日PCT。本发明涉及一种制造具有高强度与生物活性的复合陶瓷材料的方法，当该材料用作牙科或矫形 植入物，其包括制备主要包含第一粉末的粉末混合物，所述第一粉末在其使用的化学状态下将在成品材料中构成生物质基质，部分地主要包含磷酸钙基材料的第二粉末。 本发明的特征在于，所述第一粉末包括属于由二氧化钛（TiO 2），氧化锆（ZrO 2）和氧化铝（Al 2 O 3）组成的组中的至少一种氧化物，其中所述第二粉末主要包括至少一种 的化合物羟磷灰石和磷酸三钙，其中原料由所述粉末混合物制成，并且所述原料压块通过在高于50MPa的压力下的热条件下的等静压力（HIP）致密化，复合材料为 其中所述基质包含所述第一粉末的一种或多种金属氧化物，其中基质所述化合物羟基磷灰石和/或磷酸三钙均匀分散。 本发明还涉及复合陶瓷材料以及完全或部分由该材料制成的主体。
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