公开(公告)号：US20180185249A1

公开(公告)日：2018-07-05

申请号：US15932180

申请日：2018-02-16

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Anil KISHEN ,  Annie SHRESTHA

IPC: A61K6/00 ,  A61N5/06 ,  A61K41/00 ,  A61C5/40 ,  A61C5/55 ,  A61K9/51

CPC classification number: A61K6/0052 ,  A61C5/40 ,  A61C5/55 ,  A61K6/0008 ,  A61K6/0035 ,  A61K6/0038 ,  A61K6/0058 ,  A61K9/5161 ,  A61K41/0057 ,  A61N5/062

Abstract: Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibactenal/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.

公开(公告)号：US20170056297A1

公开(公告)日：2017-03-02

申请号：US15264364

申请日：2016-09-13

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Anil KISHEN ,  Annie SHRESTHA

IPC: A61K6/00 ,  A61C5/02

CPC classification number: A61K6/0052 ,  A61C5/40 ,  A61C5/55 ,  A61K6/0008 ,  A61K6/0035 ,  A61K6/0038 ,  A61K6/0058 ,  A61K9/5161 ,  A61K41/0057 ,  A61N5/062

Abstract: Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibacterial/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.

Abstract translation: 壳聚糖纳米粒子用于体内治疗根管治疗中的结缔组织。 纳米颗粒任选地与一种或多种可光活化化合物连接以提供抗细菌/抗菌膜性质，中和细菌副产物和/或化学/光动力学交联，以实现增强的机械性能，结缔组织中的化学稳定性和/或改善填充之间的表面/界面完整性 材料和结缔组织。