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    Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate
    2.
    发明授权
    Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate 失效
    从乳清渗透物，酵母膏和酵母浓缩物生产培养的酵母产品

    公开(公告)号：US5486368A

    公开(公告)日：1996-01-23

    申请号：US890513

    申请日：1992-05-28

    申请人： Rudolf de Boer ,  Roland K. Kramer ,  Ronald W. McKernan

    发明人： Rudolf de Boer ,  Roland K. Kramer ,  Ronald W. McKernan

    IPC分类号： A23K1/08 ,  A23L1/30 ,  C12N1/06 ,  A23C21/00 ,  A23J1/18 ,  A23L1/28 ,  C12N1/16

    CPC分类号： C12N1/063 ,  A23K10/28 ,  A23L33/145 ,  Y02P60/875 ,  Y10S435/804

    摘要： A modified cultured yeast product for human and animal consumption is produced by combining yeast cream and yeast centrate to produce a cream/centrate mixture, autolyzing the mixture, inactivating by heating the mixture and optionally drying. After autolysis, hydrolysis may be carried out by the use of acids, alkalis or enzymes. The yeast cream and yeast centrate are preferably produced by culturing Kluveromyces marxianus or Candida intermedia in a whey permeate and separating yeast cream and yeast centrate from the cultured whey permeate. The cream and centrate are combined such that the ratio of total solids of cream to total solids of centrate is between about 0.3 and 1.6 and preferably about 1:1.

    摘要翻译： 通过将酵母奶油和酵母浓缩物混合以产生奶油/中心液混合物，自动混合混合物，通过加热混合物并任选地干燥来灭活来生产用于人和动物消费的改良的培养的酵母产物。 自溶后，可以使用酸，碱或酶进行水解。 酵母乳膏和酵母浓缩物优选通过在乳清渗透物中培养马克斯克鲁维酵母或中间假丝酵母并从培养的乳清渗透物中分离酵母乳膏和酵母浓缩物来产生。 奶油和浓缩物的组合使得奶油的总固体与浓度的总固体的比例在约0.3至1.6之间，优选约1:1。

    Monoclonal antibodies to pseudomonas aeruginosa flagella
    4.
    发明授权
    Monoclonal antibodies to pseudomonas aeruginosa flagella 失效
    单克隆抗体对铜绿假单胞菌的鞭毛

    公开(公告)号：US4834976A

    公开(公告)日：1989-05-30

    申请号：US946554

    申请日：1986-12-24

    申请人： Mae J. Rosok ,  Mark E. Lostrom

    发明人： Mae J. Rosok ,  Mark E. Lostrom

    IPC分类号： A61K38/00 ,  C07K16/12 ,  G01N33/569

    CPC分类号： C07K16/1214 ,  G01N33/56911 ,  A61K38/00 ,  Y10S435/804 ,  Y10S435/875 ,  Y10S436/811

    摘要： Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.Prior to filing this application, the continuous transformed cell lines PaF4 IVE8, FA6 IIG5, 20H11, and 21B8, described herein, were deposited in the America Type Culture Collection and given the designations HB9129, HB9130, CRL 9300, and CRL 9301, respectively.

    摘要翻译： 已经产生分泌能够结合选定的铜绿假单胞菌菌株的鞭毛蛋白的单克隆抗体的细胞系。 已经发现这些抗体中的一些是针对铜绿假单胞菌的致死性挑战的保护物。 包含可与其它单克隆抗体组合的这些抗体，血浆级分和抗微生物剂的药物组合物，以及这些组合物在感染管理中的预防和治疗用途。 在提交本申请之前，将本文所述的连续转化细胞系PaF4 IVE8，FA6 IIG5,20H11和21B8保藏在美国典型培养物保藏中，并分别给予HB9129，HB9130，CRL9300和CRL 9301。

    Interferon epsilon
    7.
    发明授权
    Interferon epsilon 失效
    干扰素ε

    公开(公告)号：US4614651A

    公开(公告)日：1986-09-30

    申请号：US628327

    申请日：1984-07-06

    申请人： Allan P. Jarvis, Jr. ,  David I. Kosowsky

    发明人： Allan P. Jarvis, Jr. ,  David I. Kosowsky

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/21 ,  C07K1/22 ,  C07K14/52 ,  C07K14/555 ,  C12P21/00 ,  C12R1/91 ,  A61K45/02

    CPC分类号： C07K14/555 ,  A61K38/00 ,  Y10S435/80 ,  Y10S435/804 ,  Y10S435/811

    摘要： Disclosed is a new material having antiviral activity designated interferon epsilon. The material may be produced, for example, by exposing primary, diploid human epithelial cells to a virus and then incubating the cells under conditions in which the new interferon is produced and is secreted into the culture medium. The material is antigenically distinct from interferon alpha, interferon beta, and interferon gamma, and displays marked antiviral activity in human epithelial cells but no detectable activity in other cell types.

    摘要翻译： 公开了一种具有抗病毒活性的新材料，称为干扰素ε。 该材料可以例如通过将初级，二倍体人上皮细胞暴露于病毒，然后在产生新的干扰素并分泌到培养基中的条件下孵育细胞来产生。 该材料与干扰素α，干扰素β和干扰素γ具有抗原性，并且在人上皮细胞中显示出显着的抗病毒活性，但在其它细胞类型中没有可检测的活性。

    Process for the culture of aerobic microorganisms
    9.
    发明授权
    Process for the culture of aerobic microorganisms 失效
    有氧微生物培养方法

    公开(公告)号：US4326035A

    公开(公告)日：1982-04-20

    申请号：US868466

    申请日：1978-01-09

    申请人： Rodolfo Gabellieri

    发明人： Rodolfo Gabellieri

    IPC分类号： C12N1/00 ,  C12N1/28 ,  C12N1/30 ,  C12N1/32

    CPC分类号： C12N1/32 ,  C12N1/00 ,  C12N1/28 ,  C12N1/30 ,  Y10S435/804 ,  Y10S435/818

    摘要： Process for the culture of aerobic microorganisms in a culture medium provided with at least one source of oxygen, at least one source of carbon and at least one source of hydrogen, comprises providing oxygen originating from the decomposition of hydrogen peroxide as a source of oxygen and providing at least one highly inflammable product as a source of carbon and hydrogen.

    摘要翻译： 在提供至少一种氧源，至少一种碳源和至少一种氢源的培养基中培养需氧微生物的方法包括提供源于作为氧源的过氧化氢分解的氧，和 提供至少一种高度易燃的产品作为碳和氢的来源。

    Method of highly concentrated cultivation of yeasts
    10.
    发明授权
    Method of highly concentrated cultivation of yeasts 失效
    高浓度培养酵母菌的方法

    公开(公告)号：US4284724A

    公开(公告)日：1981-08-18

    申请号：US5225

    申请日：1979-01-22

    申请人： Hideki Fukuda ,  Takeshi Shiotani ,  Wataru Okada

    发明人： Hideki Fukuda ,  Takeshi Shiotani ,  Wataru Okada

    IPC分类号： C12N1/16 ,  C12N1/18 ,  C12N1/32

    CPC分类号： C12N1/32 ,  C12N1/16 ,  C12N1/18 ,  Y10S435/80 ,  Y10S435/804 ,  Y10S435/813 ,  Y10S435/94

    摘要： A broth containing yeast cells is continuously or intermittently removed from a fermentor. Then, yeast cells are separated from the filtrate using a cell separator, or further washed with water. Then, the yeast cells so obtained are recycled to the fermentor, whereby yeasts are cultivated at a high cell concentration of from 6% to about 20% based on dry weight. As discussed herein, by removing the filtrate from the cultivation system, there is no accumulation of metabolites and salts prohibiting the cultivation of yeasts, and further the growth of miscellaneous microorganisms which interfere with yeast cell growth, is surprisingly suppressed.

    摘要翻译： 含有酵母细胞的肉汤从发酵罐中连续或间歇地除去。 然后，使用细胞分离器从滤液中分离酵母细胞，或进一步用水洗涤。 然后将如此获得的酵母细胞再循环到发酵罐中，由此基于干重将酵母以6％至约20％的高细胞浓度培养。 如本文所讨论的，通过从培养系统中除去滤液，没有代谢物和盐的积累，禁止培养酵母，并且进一步抑制干扰酵母细胞生长的杂种微生物的生长令人惊奇地被抑制。