公开(公告)号：US20230258918A1

公开(公告)日：2023-08-17

申请号：US18014697

申请日：2021-07-07

Applicant: Secretary, Department of Biotechnology

Inventor： Ashutosh Patra ,  Praveen Kumar ,  Tushar Sehgal

IPC: G02B21/12 ,  G02B21/00 ,  G02B21/26 ,  G02B21/24 ,  G01N21/65 ,  G06V10/143 ,  G06V10/25 ,  G06V10/82 ,  G06V10/147 ,  G06V20/69

CPC classification number: G02B21/125 ,  G02B21/008 ,  G02B21/26 ,  G02B21/248 ,  G02B21/0032 ,  G02B21/241 ,  G01N21/65 ,  G06V10/143 ,  G06V10/25 ,  G06V10/82 ,  G06V10/147 ,  G06V20/693 ,  G02B27/141

Abstract: The invention relates to the domain of microscope based imaging. The invention provides methods and apparatuses for providing improved microscope based digital imaging solutions that are capable of providing high quality images with a high level of image detail. The invention additionally provides solutions for artificial intelligence based controlling of a digital microscope's imaging functions to enable bright field/dark field imaging functionality to be combined with spectroscopic functions to obtain higher detail and more meaningful information about a specimen sample.

公开(公告)号：US20230152566A1

公开(公告)日：2023-05-18

申请号：US17798623

申请日：2020-02-26

Applicant: Hitachi High-Tech Corporation

Inventor： Kento NISHIURA

IPC: G02B21/06 ,  G02B21/26 ,  G02B21/24 ,  G02B7/28

CPC classification number: G02B21/06 ,  G02B21/26 ,  G02B21/248 ,  G02B7/282

Abstract: The present invention provides a technology whereby relative positioning in the horizontal direction between a specimen observation area in a specimen container and an imaging field of view can be reliably performed, even prior to adjusting the focal position in the vertical direction using an auto-focus system. This specimen observation apparatus: obtains a luminance value for an image at a plurality of locations in the specimen container, prior to performing auto-focus; and uses the number of high-luminance regions and the width of those regions and identifies a central position, in the horizontal direction, in the specimen container or uses the number of low-luminance regions and the width of those regions and identifies the central position, in the horizontal direction, in the specimen container.

公开(公告)号：US20190086655A1

公开(公告)日：2019-03-21

申请号：US15706331

申请日：2017-09-15

Applicant: Agile Focus Designs, LLC

Inventor： Sarah Lukes

IPC: G02B21/02 ,  G02B26/08 ,  G02B5/04 ,  G02B15/14 ,  G02B27/28 ,  G02B21/36 ,  G02B21/24 ,  G02B7/18

CPC classification number: G02B21/025 ,  G02B5/04 ,  G02B7/181 ,  G02B15/14 ,  G02B21/241 ,  G02B21/248 ,  G02B21/361 ,  G02B21/362 ,  G02B26/085 ,  G02B27/283

Abstract: A dynamic focus and zoom system with three MEMS mirrors, three prisms, three beam splitters, three fixed lenses and an optical relay, all within a housing. The second prism, first and second fixed lenses, and first beam splitter are aligned linearly along a longitudinal axis of the optical relay. The first and second MEMS mirrors are linearly aligned with one another at a ninety-degree angle to such longitudinal axis. The third MEMS mirror, third fixed lens, third wave plate, third beam splitter and third prism are linearly aligned with one another at a ninety-degree angle to the same longitudinal axis. The third prism abuts up against the center of the optical relay between the first and second fixed lenses and is linearly aligned with the first prism such that the linear alignment of the first and third prisms is parallel to the longitudinal axis of the optical relay.

公开(公告)号：US20180136445A1

公开(公告)日：2018-05-17

申请号：US15793660

申请日：2017-10-25

Applicant: OLYMPUS CORPORATION

Inventor： Tatsuo NAKATA ,  Kenichi KUSAKA

IPC: G02B21/02 ,  G02B21/08 ,  G02B21/24

CPC classification number: G02B21/02 ,  G02B21/002 ,  G02B21/0076 ,  G02B21/025 ,  G02B21/08 ,  G02B21/24 ,  G02B21/248 ,  G02B21/361

Abstract: To provide a microscope including: an objective optical system that condenses light from a sample; a relay optical system that relays the light condensed by the objective optical system; a photodetector detects the light coming from the objective optical system and relayed by the relay optical system; and a variable-focus optical system disposed at a position between the photodetector and the objective optical system, the position being optically conjugate to a pupil of the objective optical system, the variable-focus optical system being capable of changing a focal position of the objective optical system in a direction along an objective optical axis.

公开(公告)号：US09952419B2

公开(公告)日：2018-04-24

申请号：US15030498

申请日：2014-10-29

Applicant: GE Healthcare Bio-Sciences AB

Inventor： David Andrew Stewart

IPC: G02B21/00 ,  G02B21/24 ,  G02B7/00 ,  G02B7/14 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36

CPC classification number: G02B21/248 ,  G02B7/004 ,  G02B7/005 ,  G02B7/14 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36

Abstract: The subject matter of the present disclosure generally relates to objective lens changers for optical instruments. In one embodiment, an objective lens changer includes an objective lens carrier moveably attached to a changer frame by a mechanical link arrangement. The objective lens carrier includes two or more objective lens positions. The mechanical link arrangement includes a first link section to provide translation of the objective lens carrier between the objective lens positions and a second link section arranged to control an alignment of the objective lens position with respect to the optical axis of the optical instrument.

公开(公告)号：US09939625B2

公开(公告)日：2018-04-10

申请号：US15001967

申请日：2016-01-20

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Hendrik Herrmann ,  Reinold Wischnewski

IPC: G02B21/33 ,  B05B9/01 ,  B05B13/02 ,  G02B21/24 ,  G02B21/26

CPC classification number: G02B21/33 ,  B05B9/01 ,  B05B13/0278 ,  G02B21/248 ,  G02B21/26

Abstract: A method for forming an immersion agent film between the sample holder and the objective of a microscope, comprising an automatic immersion module for supplying immersion agent from an immersion agent reservoir to a target position on the sample holder or on the positioning stage, the automatic immersion module having a spraying device with a nozzle connected to a pump for the purpose of generating an immersion agent jet. A dosed immersion agent jet is sprayed via the automatic immersion module onto a target position on the sample holder or a position on the positioning stage, at a defined speed.

公开(公告)号：US20180003941A1

公开(公告)日：2018-01-04

申请号：US15547003

申请日：2016-01-28

Applicant: Molecular Devices, LLC

Inventor： Loren A. STAUFFER

IPC: G02B21/36 ,  H04N5/232 ,  G02B21/24 ,  G02B21/12 ,  G02B21/16

CPC classification number: G02B21/365 ,  G02B21/0076 ,  G02B21/12 ,  G02B21/16 ,  G02B21/245 ,  G02B21/248 ,  G02B21/361 ,  H04N5/23222 ,  H04N5/23245

Abstract: A high content imaging system and a method of operating the high content imaging system are disclosed. A microscope has a first objective lens and a second objective lens, and an objective lens database has first and second transformation values associated with the first and the second objective lenses, respectively. A microscope controller operates the microscope with the first objective lens to develop first values of acquisition parameters. A configuration module automatically determines second values of the acquisition parameters using the first values of the acquisition parameters, first transformation values associated with the first objective lens, and second transformation values associated with the second objective lens. The microscope controller operates the microscope using the second objective lens and the second values of the acquisition parameters.

公开(公告)号：US09778450B2

公开(公告)日：2017-10-03

申请号：US14837088

申请日：2015-08-27

Applicant: Diagnostic Instruments, Inc.

Inventor： Philip T. Merlo ,  John J. Torongo

IPC: G02B21/24

CPC classification number: G02B21/248 ,  G02B21/24

Abstract: An optical device magnification level reader includes a base configured for attachment to an optical device, such as a microscope, where the base supports other components of the reader including a support arm and an electronic scanner. At least two indicia elements are positioned at different locations along the microscope. The different locations correspond to different respective magnification levels of the microscope. The electronic scanner is coupled to the base via the support arm, and is repositionable relative to the base and indicia elements to achieve proper alignment. The electronic scanner is in electronic communication with a computer associated with the microscope and is operable to detect the indicia element that corresponds to a current selected magnification level of the microscope, so that the electronic scanner is operable to send to the computer a signal indicative of the selected magnification level.

公开(公告)号：US20170161930A1

公开(公告)日：2017-06-08

申请号：US15352695

申请日：2016-11-16

Applicant: OLYMPUS CORPORATION

Inventor： Takahiko KAKEMIZU ,  Shodai HOSONO

IPC: G06T11/60 ,  H04N7/18 ,  G06T5/00 ,  G02B5/08 ,  G02B21/26 ,  G02B21/08 ,  G02B21/02 ,  G02B21/24 ,  H04N5/265 ,  G02B21/36

CPC classification number: G06T11/60 ,  G02B5/08 ,  G02B21/02 ,  G02B21/082 ,  G02B21/248 ,  G02B21/26 ,  G02B21/367 ,  G02B21/368 ,  G06T5/001 ,  G06T7/33 ,  G06T2207/10056 ,  G06T2207/20221 ,  H04N5/265 ,  H04N7/183

Abstract: A microscope includes a driving controller, a position detector, an image capturing device, an image generator, a first correction amount detector, a second correction amount detector, and a decision device for correction amount. The driving controller changes an image pickup area of a sample. The position detector detects position information of the driving controller. The image capturing device captures frame images in the image pickup area. The first and second correction amount detectors respectively detect first and second correction amounts from the frame images. The decision device for correction amount compares a prescribed value and the first correction amount, and thereby selects one of the first correction amount and the second correction amount. The image generator pastes the frame images together on the basis of the first or second correction amount selected by the decision device for correction amount, and thereby assembles a pasted-together image.

公开(公告)号：US20170076481A1

公开(公告)日：2017-03-16

申请号：US15343692

申请日：2016-11-04

Applicant: OLYMPUS CORPORATION

Inventor： Shunichi KOGA

IPC: G06T11/60 ,  G06T5/50 ,  G02B21/24 ,  G02B21/26 ,  G02B21/08 ,  G02B21/02 ,  G06T5/00 ,  G02B21/36

CPC classification number: G06T11/60 ,  G02B5/005 ,  G02B21/0032 ,  G02B21/025 ,  G02B21/082 ,  G02B21/248 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G02B21/362 ,  G02B21/367 ,  G06T5/001 ,  G06T5/50 ,  G06T2207/10056 ,  G06T2207/20221 ,  H04N5/3572

Abstract: An image processing device includes: an image acquiring unit that acquires first and second image groups, each image sharing a common part of a subject with the other image in different first and second directions; a calculating unit that calculates, as a shading component, a ratio of luminance of an area in one or more images, the area sharing a common subject with another area including a flat area whose shading component is constant in a single image other than the one or more images, to luminance of the another area, for each of the first and second image groups; and a correcting unit that performs a shading correction on shading areas in the images using the shading component. The shading component includes a normalized shading component based on luminance of the flat area, and a non-normalized shading component based on luminance of an area other than the flat area.

Abstract translation: 图像处理装置包括：图像获取单元，其获取第一和第二图像组，每个图像在不同的第一和第二方向上与另一图像共享对象的公共部分; 计算单元，其计算一个或多个图像中的区域的亮度的比率，所述区域与共享被摄体的共享区域的另一区域包括除了一个图像之外的单个图像中的阴影分量恒定的平坦区域 或更多的图像，对于第一和第二图像组中的每一个，对另一区域的亮度; 以及校正单元，其使用阴影分量对图像中的阴影区域进行阴影校正。 阴影分量包括基于平坦区域的亮度的归一化阴影分量和基于平坦区域以外的区域的亮度的非归一化阴影分量。