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    Preparation of 4-amino-2,4-dioxobutanoic acid
    4.
    发明授权
    Preparation of 4-amino-2,4-dioxobutanoic acid 有权
    4-氨基-2,4-二氧代丁酸的制备

    公开(公告)号：US09290443B2

    公开(公告)日：2016-03-22

    申请号：US14489329

    申请日：2014-09-17

    申请人： Los Alamos National Security, LLC ,  New Mexico Highlands University

    发明人： Pat J. Unkefer ,  Rodolfo A. Martinez ,  David R. Glass

    IPC分类号： C07C229/00 ,  C07C231/06 ,  C07C253/30

    CPC分类号： C07C231/065 ,  C07C253/30 ,  C07C255/23 ,  C07C235/80

    摘要： A process for synthesizing 4-amino-2,4-dioxobutanoate involves reacting a dialkyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding an alkyl cyano acetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoate. The 4-amino-2,4-dioxobutanoate may be acidified into 4-amino-2,4-dioxobutanoic acid.

    摘要翻译： 合成4-氨基-2,4-二氧代丁酸酯的方法包括使草酸二烷基酯与乙醇中的醇盐反应以形成反应混合物，然后向反应混合物中加入氰基乙酸烷基酯，并使反应在适于 形成2-氰基-3-羟基 - 丁烯二酸二乙酯的第一反应产物，然后分离2-氰基-3-羟基 - 丁烯二酸二乙酯，然后使2-氰基-3-羟基 - 丁烯二酸二乙酯与 氢氧化物在适于形成4-氨基-2,4-二氧代丁酸酯的条件下。 4-氨基-2,4-二氧代丁酸酯可酸化成4-氨基-2,4-二氧代丁酸。

    SUTURE MANUFACTURED USING POLY OCTYL CYANOACRYLATE AND MANUFACTURING METHOD THEREFOR
    8.
    发明申请
    SUTURE MANUFACTURED USING POLY OCTYL CYANOACRYLATE AND MANUFACTURING METHOD THEREFOR 审中-公开
    使用聚氨基甲酸丙烯酸酯制造的制品及其制造方法

    公开(公告)号：US20130226236A1

    公开(公告)日：2013-08-29

    申请号：US13883109

    申请日：2011-11-02

    申请人： Dong Jin Kim

    发明人： Dong Jin Kim

    IPC分类号： A61L17/10 ,  D04C1/12

    CPC分类号： A61L17/10 ,  C07C253/30 ,  D01F6/16 ,  D04C1/12 ,  D10B2509/04 ,  C07C255/19 ,  C07C255/23

    摘要： The disclosure relates to a suture manufactured using poly octyl cyanoacrylate, and a method for manufacturing same. The disclosure provides a method for manufacturing a suture, and a suture prepared using the method, the method comprising: a step for preparing octyl cyanoacetate by reacting cyanoacetic acid and octane alcohol by 1:1 equivalence ratio under the existence of a solvent; a step for reacting the octyl cyanoacetate and paraformaldehyde by 1:1 equivalence ratio under the existence of a solvent; a step for isolating and refining octyl cyanoacrylate after removing the solvent when the reaction is completed; a step for collecting poly octyl cyanoacrylate from the byproduct left from refining octyl cyanoacrylate; and a step for manufacturing a suture by a braid process after manufacturing a thread by melt spinning and extrusion molding the collected poly octyl cyanoacrylate.

    摘要翻译： 本公开涉及使用聚氰基丙烯酸辛酯制造的缝线及其制造方法。 本公开内容提供了一种缝合线的制造方法和使用该方法制备的缝合线，该方法包括：在溶剂存在下使氰基乙酸和辛烷醇以1:1当量比进行反应制备氰基乙酸辛酯的步骤; 在溶剂存在下使氰基乙酸辛酯和多聚甲醛反应1当量比的步骤; 当反应完成后，除去溶剂后，分离和精制氰基丙烯酸辛酯的步骤; 从精炼氰基丙烯酸辛酯的副产物中收集氰基丙烯酸辛酯的步骤; 以及通过熔融纺丝和挤出成型聚集的氰基丙烯酸辛酯制造线后通过编织工艺制造缝合线的步骤。