公开(公告)号：US09789207B1

公开(公告)日：2017-10-17

申请号：US15184129

申请日：2016-06-16

Applicant: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.

Inventor： Li-Yuan Huang ,  Yean-Hung Tu ,  Jenn-Tzong Chen ,  Chyng-Yann Shiue

IPC: A61K49/00 ,  C07C255/09

CPC classification number: A61K49/0052 ,  A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C253/30 ,  C07C255/09 ,  C07C255/42

Abstract: A PET imaging agent is made, by at first, washing out fluoride ions (F-18) adhered on an ion exchange resin to a reaction vessel with potassium carbonate/Kryptofix 2.2.2 in acetonitrile-water. After processing the first azeotropic distillation with helium while water is removed, the temperature is cooled down. Then, acetonitrile is added to the reaction vessel to be heated up. After processing the second azeotropic distillation with helium while water is removed, the temperature is cooled down and excess water is extracted. A precursor is then added to the reaction vessel to be heated up for processing a fluorination reaction. The reaction mixture obtained after the fluorination reaction is cooled down to be flown through a solid-phase extraction column with waste drained into a waste tank. Then, ethanol is used to wash out a product, i.e. [F-18]FEONM, adsorbed by the column, to be collected in a collection vial.

公开(公告)号：US08952156B2

公开(公告)日：2015-02-10

申请号：US13598691

申请日：2012-08-30

Applicant: Hermann Luyken ,  Sebastian Ahrens ,  Gordon Brasche ,  Jens Baldamus ,  Robert Baumann ,  Randolf Hugo ,  Stephanie Jaegli ,  Johann-Peter Melder ,  Jörg Pastre ,  Boris Buschhaus

Inventor： Hermann Luyken ,  Sebastian Ahrens ,  Gordon Brasche ,  Jens Baldamus ,  Robert Baumann ,  Randolf Hugo ,  Stephanie Jaegli ,  Johann-Peter Melder ,  Jörg Pastre ,  Boris Buschhaus

IPC: C07C213/02 ,  B01D3/36 ,  C07C209/48 ,  C07C209/86 ,  C07C253/00 ,  B01D3/14 ,  C08G59/50

CPC classification number: B01D3/36 ,  B01D3/143 ,  C07C209/48 ,  C07C209/86 ,  C07C253/00 ,  C08G59/502 ,  C07C211/14 ,  C07C255/09 ,  C07C255/25

Abstract: A process is disclosed for separating the output from the reaction of EDDN or EDMN with hydrogen in the presence of THF, a catalyst, TETA or DETA, water, and optionally organic compounds having higher and lower boiling points than TETA or DETA. Hydrogen is removed, and the output is supplied to a distillation column DK1 in which an azeotrope, optionally comprising organic compounds with a boiling point lower than TETA or DETA, is removed from the top. A product comprising TETA or DETA is removed from the bottom and passed into a distillation column DK2, removing THF. A stream comprising TETA or DETA passes from the bottom of DK2. The DK1 azeotrope is condensed. Phase separation is induced by the addition of an organic solvent essentially immiscible with water, and the mixture is separated. The organic phase is recycled into DK1 and the water phase is discharged.

Abstract translation: 公开了一种在THF，催化剂，TETA或DETA，水和具有比TETA或DETA具有更高和更低沸点的任何有机化合物存在下将EDDN或EDMN与氢气反应的输出分离出来的方法。 除去氢气，并将输出物供给到蒸馏塔DK1，在该蒸馏塔DK1中，从顶部除去任选包含沸点低于TETA或DETA的有机化合物的共沸物。 将包含TETA或DETA的产物从底部除去并进入蒸馏塔DK2中，除去THF。 包含TETA或DETA的流从DK2的底部通过。 DK1共沸物浓缩。 通过加入基本上与水不混溶的有机溶剂诱导相分离，并分离混合物。 有机相再循环到DK1中，水相排出。

公开(公告)号：US20130310594A1

公开(公告)日：2013-11-21

申请号：US13752361

申请日：2013-01-28

Applicant: OPTMED, INC.

Inventor： Francis McConville ,  John Gregory Reid ,  Murugappa Vedachalam

IPC: C07C253/30 ,  C07C67/00

CPC classification number: C07C253/30 ,  B01D15/00 ,  C07C67/00 ,  C07C67/56 ,  C07C231/24 ,  C07C253/34 ,  C10G70/046 ,  C07C255/23 ,  C07C255/17 ,  C07C255/09 ,  C07C255/07 ,  C07C233/09 ,  C07C69/73 ,  C07C69/593

Abstract: An improvement in the production of 1,1-disubstituted ethylenes is attained by contacting a 1,1-disubstituted ethylene with alumina and separating the alumina to obtain a 1,1-disubstituted ethylene with a good combination of cost, purity, shelf life and cure rate.

Abstract translation: 通过使1,1-二取代的乙烯与氧化铝接触并分离氧化铝以获得1,1-二取代的乙烯，其成本，纯度，保质期和 治愈率。

公开(公告)号：US20130085255A1

公开(公告)日：2013-04-04

申请号：US13442306

申请日：2012-04-09

Applicant: Laetitia Coudray ,  Vu Bui ,  John W. Frost ,  Dirk Schweitzer

Inventor： Laetitia Coudray ,  Vu Bui ,  John W. Frost ,  Dirk Schweitzer

IPC: C07D223/10

CPC classification number: C07D223/10 ,  C07C209/48 ,  C07C231/02 ,  C07C235/74 ,  C07C235/76 ,  C07C255/04 ,  C07C255/09 ,  C08G69/26 ,  C08G69/28 ,  C07C211/12

Abstract: Provided herein are processes for preparing caprolactam from a starting material such as one or more of the cis,cis-, cis,trans- and trans,trans-double-bond isomers of muconamide, muconic acid ester, or muconic acid. The starting material, intermediates, and caprolactam prepared therefrom can contain carbon atoms derived from biomass containing detectable 14C content determined according to ASTM D6866 and optionally containing a 14C content up to 0.0000000001% (one part per trillion). Caprolactam so prepared can be used to make various polyamides.

Abstract translation: 本文提供了从起始材料如粘蛋白酰胺，粘康酸酯或粘康酸的顺式，顺式，顺式，反式和反式，反式 - 双键异构体中的一种或多种制备己内酰胺的方法。 由其制备的起始原料，中间体和己内酰胺可以包含衍生自含有根据ASTM D6866测定的可检测14C含量的生物质的碳原子，并且任选含有高达0.0000000001％（一兆份）的14C含量。 如此制备的己内酰胺可用于制备各种聚酰胺。

公开(公告)号：US20130060002A1

公开(公告)日：2013-03-07

申请号：US13598691

申请日：2012-08-30

Applicant: Hermann Luyken ,  Sebastian Ahrens ,  Gordon Brasche ,  Jens Baldamus ,  Robert Baumann ,  Randolf Hugo ,  Stephanie Jaegli ,  Johann-Peter Melder ,  Jörg Pastre ,  Boris Buschhaus

Inventor： Hermann Luyken ,  Sebastian Ahrens ,  Gordon Brasche ,  Jens Baldamus ,  Robert Baumann ,  Randolf Hugo ,  Stephanie Jaegli ,  Johann-Peter Melder ,  Jörg Pastre ,  Boris Buschhaus

IPC: B01D3/36 ,  C08G69/00 ,  C08G59/02 ,  C07C209/48 ,  C07C231/00

CPC classification number: B01D3/36 ,  B01D3/143 ,  C07C209/48 ,  C07C209/86 ,  C07C253/00 ,  C08G59/502 ,  C07C211/14 ,  C07C255/09 ,  C07C255/25

Abstract: A process is disclosed for separating the output from the reaction of EDDN or EDMN with hydrogen in the presence of THF, a catalyst, TETA or DETA, water, and optionally organic compounds having higher and lower boiling points than TETA or DETA. Hydrogen is removed, and the output is supplied to a distillation column DK1 in which an azeotrope, optionally comprising organic compounds with a boiling point lower than TETA or DETA, is removed from the top. A product comprising TETA or DETA is removed from the bottom and passed cinto a distillation column DK2, removing THF. A stream comprising TETA or DETA passes from the bottom of DK2. The DK1 azeotrope is condensed. Phase separation is induced by the addition of an organic solvent essentially immiscible with water, and the mixture is separated. The organic phase is recycled into DK1 and the water phase is discharged.

Abstract translation: 公开了一种在THF，催化剂，TETA或DETA，水和具有比TETA或DETA具有更高和更低沸点的任何有机化合物的存在下将EDDN或EDMN与氢反应的输出分离出来的方法。 除去氢气，并将输出物供给到蒸馏塔DK1，在该蒸馏塔DK1中，从顶部除去任选包含沸点低于TETA或DETA的有机化合物的共沸物。 包含TETA或DETA的产品从底部除去并通过蒸馏塔DK2，除去THF。 包含TETA或DETA的流从DK2的底部通过。 DK1共沸物浓缩。 通过加入基本上与水不混溶的有机溶剂诱导相分离，并分离混合物。 有机相再循环到DK1中，水相排出。

公开(公告)号：US20090270645A1

公开(公告)日：2009-10-29

申请号：US12296038

申请日：2007-03-28

Applicant: Gerd Haderlein ,  Tobias Aechtner ,  Michael Bartsch ,  Hermann Luyken ,  Peter Pfab ,  Jens Scheidel ,  Andreas Leitner

Inventor： Gerd Haderlein ,  Tobias Aechtner ,  Michael Bartsch ,  Hermann Luyken ,  Peter Pfab ,  Jens Scheidel ,  Andreas Leitner

IPC: C07F9/28 ,  C07F9/06

CPC classification number: B01J31/403 ,  B01D11/0426 ,  B01D11/0457 ,  B01J31/1845 ,  B01J31/185 ,  B01J31/1865 ,  B01J31/24 ,  B01J31/4053 ,  C07C253/34 ,  C07D333/48 ,  Y02P20/584 ,  C07C255/09

Abstract: A process for extractively removing nickel(0) complexes having phosphorus ligands from a reaction effluent of a hydrocyanation of unsaturated mononitriles to dinitriles by extraction by means of a hydrocarbon, a phase separation of the hydrocarbon and of the nitrile-containing solution into two phases being effected, by feeding at least one polar additive to the hydrocyanation effluent (feedstream) and/or to the extraction stage.

Abstract translation: 一种从不饱和单腈的氢氰化反应流出物中通过烃萃取将具有磷配体的镍（0）络合物从碳氢化合物萃取到二腈的方法，将烃和含腈溶液相分离成两相，即 通过将至少一种极性添加剂进料到氢化氰化流出物（进料流）和/或提取阶段来实现。

公开(公告)号：US20080015381A1

公开(公告)日：2008-01-17

申请号：US11776954

申请日：2007-07-12

Applicant: THOMAS FOO ,  James Michael Garner ,  Ron Ozer

Inventor： THOMAS FOO ,  James Michael Garner ,  Ron Ozer

IPC: C07C253/10

CPC classification number: C07C253/10 ,  C07C255/09

Abstract: The invention provides a hydrocyanation process for the production of adiponitrile and other dinitriles having six carbon atoms, the process comprising: a) forming a reaction mixture in the presence of at least one Lewis acid, said reaction mixture comprising ethylenically unsaturated nitrites having five carbon atoms, hydrogen cyanide, and a catalyst precursor composition, by continuously feeding ethylenically unsaturated nitrites, hydrogen cyanide, and a catalyst precursor composition; b) controlling X and Z, wherein X is the overall feed molar ratio of 2-pentenenitriles to all unsaturated nitriles and Z is the overall feed molar ratio of hydrogen cyanide to all unsaturated nitrites, by selecting a value for X in the range from about 0.001 to about 0.5, and a value for Z in the range from about 0.5/1 to about 0.99/1, such that the value of quotient Q, wherein Q = X [ ( moles   3  PN + 4  PN   in   the   feed ) ( moles   all   unsaturated   nitriles   in   the   feed ) ] - Z is in the range from about 0.2 to about 10, wherein 3PN is 3-pentenenitriles and 4PN is 4-pentenenitrile; and c) withdrawing a reaction product mixture comprising adiponitrile; wherein the ratio of the concentration of 2-pentenenitriles to the concentration of 3-pentenenitriles in the reaction mixture is from about 0.2/1 to about 10/1; wherein the catalyst precursor composition comprises a zero-valent nickel and at least one bidentate phosphite ligand; and wherein the bidentate phosphite ligand is selected from a member of the group represented by Formulas I and 11 as described herein.

公开(公告)号：US20080004462A1

公开(公告)日：2008-01-03

申请号：US11667960

申请日：2005-11-21

Applicant: Alexander Peters ,  Peter Schevelier

Inventor： Alexander Peters ,  Peter Schevelier

IPC: C07C253/24 ,  B01J21/08 ,  B01J23/30

CPC classification number: B01J35/023 ,  B01J21/063 ,  B01J23/002 ,  B01J23/30 ,  B01J27/199 ,  B01J37/0045 ,  B01J2523/00 ,  C07C253/26 ,  B01J2523/41 ,  B01J2523/55 ,  B01J2523/69 ,  C07C255/09

Abstract: The invention relates to a catalyst comprising a titanium dioxide carrier and a mixture of metal oxides comprising at least one oxide of a metal selected from the group consisting of vanadium and tungsten and silicon oxide, comprised in such an amount that silicon (Si) is present in the catalyst in an amount of at least 1.0 wt %, relative to the weight of the catalyst. The invention also relates to a process for the preparation of fumaronitrile and/or maleonitrile by ammoxidation of C4-straight chain hydrocarbons in the presence of a catalyst according to the invention.

Abstract translation: 本发明涉及包含二氧化钛载体和金属氧化物的混合物的催化剂，该金属氧化物包含至少一种选自钒和钨的氧化物和氧化硅，其含量以硅（Si）的量存在 在催化剂中的量相对于催化剂的重量为至少1.0重量％。 本发明还涉及在根据本发明的催化剂存在下，通过C 4 - 直链烃的氨氧化制备富马腈和/或马来腈的方法。

公开(公告)号：US06924345B2

公开(公告)日：2005-08-02

申请号：US10659205

申请日：2003-09-10

Applicant: Michel R. Gagne ,  Kenneth G. Moloy ,  Nora S. Radu ,  Brian P. Santora ,  Wilson Tam

Inventor： Michel R. Gagne ,  Kenneth G. Moloy ,  Nora S. Radu ,  Brian P. Santora ,  Wilson Tam

IPC: B01J31/16 ,  B01J31/18 ,  B01J31/22 ,  B01J31/26 ,  C07B61/00 ,  C07C45/49 ,  C07C45/50 ,  C07C47/02 ,  C07C253/10 ,  C07C253/30 ,  C07C255/02 ,  C07C255/06 ,  C07C255/09 ,  C07C255/17 ,  C07F9/46 ,  C07F9/48 ,  C07F15/00 ,  C07F15/04 ,  C07F15/06 ,  C08F8/00 ,  C08F12/00 ,  C08F20/30 ,  C08F22/20 ,  C08F30/02 ,  C08F130/02

CPC classification number: B01J31/1658 ,  B01J31/185 ,  B01J31/1865 ,  B01J31/1875 ,  B01J31/1885 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/26 ,  B01J31/30 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/845 ,  B01J2531/847 ,  C07C45/49 ,  C07C45/50 ,  C07C253/10 ,  C07C253/30 ,  C07F15/0066 ,  C07F15/045 ,  C07F15/065 ,  C08F12/24 ,  C08F30/02 ,  C08F212/08 ,  C08F212/14 ,  C08F212/32 ,  C08F212/36 ,  C08F230/02 ,  C07C47/19 ,  C07C255/06 ,  C07C255/09 ,  C07C255/17 ,  C07C47/02

Abstract: A polymeric, phosphorus-containing composition made by heating, in the presence of an initiator, preferably a free radical initiator, and optionally in the presence of one or more comonomers, at least one substituted phosphonylated 2,2′-dihydroxyl-1,1′-binaphthalene or at least one substituted 2,2′-dihydroxyl-1,1′-biphenylene.

Abstract translation: 通过在引发剂存在下，优选自由基引发剂和任选在一种或多种共聚单体存在下，加入至少一种取代的膦酰化的2,2'-二羟基-1,1 ' - 联萘或至少一个取代的2,2'-二羟基-1,1'-联亚苯基。

公开(公告)号：US20040138494A1

公开(公告)日：2004-07-15

申请号：US10341860

申请日：2003-01-14

Inventor： Scott C. Jackson ,  Ronald J. McKinney

IPC: C07C253/02

CPC classification number: B01J31/30 ,  B01J31/185 ,  B01J31/1875 ,  B01J37/16 ,  B01J2231/32 ,  B01J2531/847 ,  C07C253/10 ,  C07C255/09

Abstract: A process for preparing a hydrocyanation catalyst comprising contacting a bidentate phosphorous-containing ligand with nickel chloride in the presence of a nitrile solvent and a reducing metal which is more electropositive than nickel the nickel chloride being introduced as an aqueous solution and the water being removed concurrently with the reduction reaction by azeotropic distillation.

Abstract translation: 一种制备氢氰化催化剂的方法，其包括在腈溶剂和还原金属存在下使二齿磷配体与氯化镍接触，所述还原金属比镍更正电，作为水溶液引入氯化镍并同时除去水 通过共沸蒸馏进行还原反应。