公开(公告)号：US12048937B2

公开(公告)日：2024-07-30

申请号：US16607343

申请日：2018-05-11

申请人： SCINOGY PRODUCTS PTY LTD

发明人： Ian Fitzpatrick ,  David James ,  Stephen Wilson

IPC分类号： B04B5/06 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M39/10 ,  A61M39/12 ,  A61M39/22 ,  A61M39/28 ,  A61M60/10 ,  A61M60/104 ,  A61M60/109 ,  B04B1/06 ,  B04B5/04 ,  B04B5/12 ,  B04B7/00 ,  B04B9/02 ,  B04B11/04 ,  B04B13/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/04 ,  G01N33/49 ,  A61M39/02

CPC分类号： B04B5/06 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/029 ,  A61M1/26 ,  A61M1/262 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3604 ,  A61M1/3606 ,  A61M1/3616 ,  A61M1/3621 ,  A61M1/3622 ,  A61M1/3693 ,  A61M1/3696 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/105 ,  A61M39/12 ,  A61M39/22 ,  A61M39/28 ,  A61M60/104 ,  A61M60/109 ,  B04B1/06 ,  B04B5/04 ,  B04B5/0442 ,  B04B5/12 ,  B04B7/00 ,  B04B9/02 ,  B04B11/04 ,  B04B13/00 ,  B04B13/003 ,  C12M23/26 ,  C12M23/28 ,  C12M27/10 ,  C12M29/00 ,  C12M33/10 ,  C12M37/04 ,  C12M47/04 ,  G01N33/491 ,  A61M1/3603 ,  A61M2039/0276 ,  A61M2039/226 ,  B04B2005/0435 ,  B04B2005/0464 ,  B04B2005/0471 ,  B04B2005/0478 ,  B04B2005/0492

摘要： Provided is a chamber configuration for a reverse flow centrifuge, and a reverse flow centrifuge system configured for low fluid volume and small radius rotation. The compact reverse flow centrifuge system has a reusable subsystem and a single use replaceable subsystem. The replaceable subsystem comprises a separation chamber, fluid delivery manifold and rotational mounting connecting the separation chamber to the fluid manifold. The single use replaceable subsystem provides a closed environment for execution of reverse flow centrifugation processes. The separation chamber has a substantially conical fluid enclosure portion connected to a neck portion, and a dip tube extends centrally through the conical fluid enclosure to provide a fluid path to the tip of the conical fluid enclosure.

公开(公告)号：US09283313B2

公开(公告)日：2016-03-15

申请号：US14615743

申请日：2015-02-06

申请人： Roche Diagnostics Operations, Inc.

发明人： Herfried Huemer

IPC分类号： A61M1/36 ,  G01N1/14 ,  G01N33/49 ,  B01L3/00

CPC分类号： A61M1/3616 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N33/491

摘要： A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyzer.

摘要翻译： 提供了用于从全血中分离血浆的多部分装置，具有用于接收全血的取样单元，具有用于提取等离子体的多层的分层过滤器的过滤单元，以及通常为柱塞泵的抽吸单元，用于产生 过滤器单元中的部分真空。 过滤器单元和具有朝向过滤器单元延伸的锥形末端的等离子体收集器容纳在过滤器滤芯中，其可以在等离子体提取之后被分离，从而将用于样品输入的等离子体收集器容器的锥形尖端暴露于分析器中。

公开(公告)号：US20020182664A1

公开(公告)日：2002-12-05

申请号：US10116729

申请日：2002-04-04

发明人： Victor D. Dolecek ,  Jeffery C. Marx ,  William F. McKay

IPC分类号： G01N001/30 ,  A01N001/02 ,  G01N033/48 ,  C12N005/08

CPC分类号： A61K35/19 ,  A61K35/15 ,  A61M1/3616 ,  A61M1/3618 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/045 ,  A61M2202/10 ,  B04B5/0428 ,  B04B5/0442 ,  B04B2005/045

摘要： Methods and apparatuses for the separation a predetermined cellular component from a bodily fluid or tissue by centrifugation are provided. More specifically, this invention provides a method for the separation and isolation of one or more components, such as stem cells, buffy coat, bone marrow cells, erythrocytes, leukocytes, thrombocytes, serum, fluorescently labeled cells, and magnetically labeled cells, from whole blood, bone marrow, buffy coat, fat tissue, muscle tissue, and nerve tissue by centrifugation, wherein the components are isolated while the centrifuge is rotating.

摘要翻译： 提供了通过离心从体液或组织分离预定的细胞组分的方法和装置。 更具体地说，本发明提供了从整体分离和分离一种或多种组分如干细胞，血沉棕黄层，骨髓细胞，红细胞，白细胞，血小板，血清，荧光标记细胞和磁性标记细胞的方法 血液，骨髓，血沉棕黄层，脂肪组织，肌肉组织和神经组织，其中在离心机旋转时分离组分。

公开(公告)号：US5908742A

公开(公告)日：1999-06-01

申请号：US692444

申请日：1996-08-05

申请人： Lily Lin ,  Laurence Corash ,  Jean Marc Payrat

发明人： Lily Lin ,  Laurence Corash ,  Jean Marc Payrat

IPC分类号： A61K31/365 ,  A61K31/37 ,  A61K35/14 ,  A61K41/00 ,  A61L2/00 ,  A61M1/36 ,  A61N5/06 ,  A01N1/02

CPC分类号： A61K31/365 ,  A01N1/021 ,  A01N1/0215 ,  A61K31/37 ,  A61K41/0019 ,  A61L2/0011 ,  A61M1/3616 ,  A61M1/3683 ,  A61M1/3686 ,  A61N5/06 ,  A61M2202/0425

摘要： Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including essentially magnesium free synthetic media formulations to be employed in conjunction with the photodecontamination of platelets.

摘要翻译： 公开了与用于体内使用的血液制剂一起使用的合成培养基制剂，其基本上不含与血小板的光化学去除联合使用的无镁合成培养基制剂。

公开(公告)号：US5288605A

公开(公告)日：1994-02-22

申请号：US844790

申请日：1992-03-02

申请人： Lily Lin ,  Lawrence Corash ,  Stephen T. Isaacs ,  Carl V. Hanson ,  George D. Cimino

发明人： Lily Lin ,  Lawrence Corash ,  Stephen T. Isaacs ,  Carl V. Hanson ,  George D. Cimino

IPC分类号： A61J3/00 ,  A01N1/02 ,  A61K31/37 ,  A61K35/14 ,  A61K41/00 ,  A61L2/00 ,  A61M1/36 ,  A61M37/00 ,  A61N1/30

CPC分类号： A61K31/37 ,  A01N1/0215 ,  A01N1/0242 ,  A01N1/0294 ,  A61K41/0019 ,  A61L2/0011 ,  A61M1/3616 ,  A61M1/3683 ,  A61M1/3686

摘要： Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated using 8-methoxypsoralen prior to long term storage and transfusion.

摘要翻译： 描述了用于治疗旨在体内使用的材料中的污染物的方法和组合物，特别是用于人类的血液和血液制品。 血液细胞制剂中的污染物在长期储存和输血之前使用8-甲氧基补骨脂素灭活。

公开(公告)号：US4737140A

公开(公告)日：1988-04-12

申请号：US54114

申请日：1987-05-22

申请人： Kyu H. Lee ,  Vernon H. Troutner ,  Jack Goss ,  Martin J. King

发明人： Kyu H. Lee ,  Vernon H. Troutner ,  Jack Goss ,  Martin J. King

IPC分类号： A61M1/36 ,  A61M37/00 ,  A61M1/03

CPC分类号： A61M1/3681 ,  A61M1/3616 ,  A61M1/3683 ,  A61M1/3693 ,  A61M2209/082 ,  Y10S128/03

摘要： A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.

摘要翻译： 可移动的U.V 用于可光活化剂的光阵列组件，其中与患者血细胞接触的光活化剂的体外照射然后返回到患者的患者治疗系统。

公开(公告)号：US4726949A

公开(公告)日：1988-02-23

申请号：US900217

申请日：1986-08-26

申请人： Jeffrey E. Miripol ,  Arnold Bilstad ,  John Foley ,  Dean Glash

发明人： Jeffrey E. Miripol ,  Arnold Bilstad ,  John Foley ,  Dean Glash

IPC分类号： A61K35/14 ,  A61M1/36

CPC分类号： A61M1/3681 ,  A61M1/3616

摘要： A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.

摘要翻译： 用紫外线辐射主要为280〜320nm的波长的白细胞的薄膜，优选为4〜15毫瓦每平方厘米的强度。 在这样的辐射强度下，不需要搅动白细胞的薄膜来实现本发明的目的。 如此处理的白细胞基本上丧失了在同种异体免疫的患者中引起免疫反应的能力。 白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。

公开(公告)号：US12083258B2

公开(公告)日：2024-09-10

申请号：US17825918

申请日：2022-05-26

申请人： Fenwal, Inc.

发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  G01N33/48 ,  G16H10/60 ,  G16H40/60

CPC分类号： A61M1/3496 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3616 ,  A61M1/362262 ,  A61M1/362266 ,  A61M1/3643 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/382 ,  A61M1/385 ,  G01N33/48 ,  G16H10/60 ,  G16H40/60 ,  A61M2202/0415 ,  A61M2205/33 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/207

摘要： A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and red blood cells, an anticoagulant line to introduce anticoagulant to the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller is configured to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor.

公开(公告)号：US11692170B2

公开(公告)日：2023-07-04

申请号：US16915818

申请日：2020-06-29

申请人： Terumo BCT, Inc.

发明人： James R. Ladtkow ,  Geoffrey M. Uhl ,  Jeremy P. Kolenbrander ,  Briden Ray Stanton

IPC分类号： C12N5/078 ,  A61M1/26 ,  A61M1/30 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B04B5/04

CPC分类号： C12N5/0641 ,  A61M1/0209 ,  A61M1/26 ,  A61M1/262 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3616 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0442 ,  B04B2005/0471

摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

公开(公告)号：US09656014B2

公开(公告)日：2017-05-23

申请号：US14879019

申请日：2015-10-08

申请人： Brian J Leberthon

发明人： Brian J Leberthon

IPC分类号： A61M37/00 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/3486 ,  A61M1/3489 ,  A61M1/3493 ,  A61M1/3616 ,  A61M1/362 ,  A61M1/3687

摘要： A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane wall portions that enable a molecular-sized activating agent in a carrier fluid that enhances an immune response to pass through these porous wall portions. Pore size is such to allow the molecular-sized activating agent in the interior of the chamber to enter the wells yet prevents immune cells and cancer cells in the wells to pass through the porous wall portions into the interior of the chamber. Blood is retained in the wells so that it remains in contact with the immune cells and cancer cells for a predetermined period sufficient to enhance an immune response. Then the cells with an enhanced immune response are return to the patient.