公开(公告)号：US12168087B2

公开(公告)日：2024-12-17

申请号：US16807254

申请日：2020-03-03

Applicant: Fenwal, Inc.

Inventor： Kyungyoon Min ,  Benjamin E. Kusters

IPC: C12N5/078 ,  A61K35/17 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  C12M1/00 ,  C12M1/42 ,  C12N5/00 ,  C12N5/0783 ,  C12N5/10 ,  C12N13/00 ,  C12N15/85

Abstract: Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

公开(公告)号：US20240245840A1

公开(公告)日：2024-07-25

申请号：US18420050

申请日：2024-01-23

Applicant: Fenwal, Inc.

Inventor： Benjamin E. Kusters ,  James Gregory Madsen ,  Kyungyoon Min

IPC: A61M1/02 ,  B04B5/04 ,  B04B11/02

CPC classification number: A61M1/0277 ,  B04B5/0442 ,  B04B11/02 ,  A61M2205/3393 ,  A61M2209/06

Abstract: A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.

公开(公告)号：US20240226916A9

公开(公告)日：2024-07-11

申请号：US18378679

申请日：2023-10-11

Applicant: Fenwal Inc.

Inventor： Benjamin E. Kusters ,  Kyungyoon Min

IPC: B04B11/02 ,  A61M1/36 ,  B01D36/04 ,  B01D63/16 ,  B04B5/04

CPC classification number: B04B11/02 ,  A61M1/3696 ,  B01D36/045 ,  B01D63/16 ,  B04B5/0442 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2205/3303

Abstract: Systems and methods are provided for collecting a platelet product having a target concentration. First and second target concentrations are first selected. Blood is then separated into red blood cells and platelet-rich plasma, with the platelet-rich plasma then being separated into platelet-poor plasma and platelet concentrate. At least a portion of the platelet concentrate is collected in a container as a platelet product having an actual platelet concentration, attempting to collect platelet concentrate having the first target concentration. After separation of the blood has been completed, at least a portion of the platelet-poor plasma and/or an additive solution is pumped into the container to decrease the concentration of the platelet product from the actual platelet concentration to the second target concentration.

公开(公告)号：US20240157038A1

公开(公告)日：2024-05-16

申请号：US18388871

申请日：2023-11-13

Applicant: Fenwal, Inc.

Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

IPC: A61M1/36

CPC classification number: A61M1/3693

Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.

公开(公告)号：US11969536B2

公开(公告)日：2024-04-30

申请号：US17117203

申请日：2020-12-10

Applicant: Fenwal, Inc.

Inventor： Benjamin E Kusters ,  Kyungyoon Min

IPC: A61M1/36

CPC classification number: A61M1/3693 ,  A61M1/3607 ,  A61M1/3621 ,  A61M1/362227 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/362261 ,  A61M1/362265 ,  A61M1/362266 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429

Abstract: Systems and methods are provided for therapeutic red blood cell exchange and/or therapeutic plasma exchange. A blood separation device includes a centrifugal separator, a spinning membrane separator drive unit, a pump system, and a controller. Blood is conveyed through a fluid flow circuit into either the centrifugal separator or the spinning membrane separator, which separates out the target blood component (red blood cells, in the case of therapeutic red blood cell exchange, or plasma, in the case of therapeutic plasma exchange). The target blood component is retained in the circuit as a waste product, while a replacement fluid is added to the remaining blood component(s), which is then conveyed to a recipient. In addition to allowing for execution of an exchange procedure using either a centrifugal separator or a spinning membrane separator drive unit, the blood separation device also allows for the use of differently sized spinning membrane separators.

公开(公告)号：US20240131528A1

公开(公告)日：2024-04-25

申请号：US18378679

申请日：2023-10-10

Applicant: Fenwal Inc.

Inventor： Benjamin E. Kusters ,  Kyungyoon Min

IPC: B04B11/02 ,  A61M1/36 ,  B01D36/04 ,  B01D63/16 ,  B04B5/04

CPC classification number: B04B11/02 ,  A61M1/3696 ,  B01D36/045 ,  B01D63/16 ,  B04B5/0442 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2205/3303

Abstract: Systems and methods are provided for collecting a platelet product having a target concentration. First and second target concentrations are first selected. Blood is then separated into red blood cells and platelet-rich plasma, with the platelet-rich plasma then being separated into platelet-poor plasma and platelet concentrate. At least a portion of the platelet concentrate is collected in a container as a platelet product having an actual platelet concentration, attempting to collect platelet concentrate having the first target concentration. After separation of the blood has been completed, at least a portion of the platelet-poor plasma and/or an additive solution is pumped into the container to decrease the concentration of the platelet product from the actual platelet concentration to the second target concentration.

公开(公告)号：US20240066190A1

公开(公告)日：2024-02-29

申请号：US18457870

申请日：2023-08-29

Applicant: Fenwal, Inc.

Inventor： Thomas Gniadek ,  Kyungyoon Min

IPC: A61M1/02

CPC classification number: A61M1/024 ,  A61M2205/502 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/50

Abstract: A method and system for donating blood and/or blood components is disclosed. The method and system include at least one adjustment mechanism to alter at least one feature of a blood draw in order to minimize and/or prevent donor reactions.

公开(公告)号：US20230402171A1

公开(公告)日：2023-12-14

申请号：US18231638

申请日：2023-08-08

Applicant: FENWAL, INC.

Inventor： Brian C. Case ,  Lan T. Nguyen ,  Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC: G16H40/60 ,  G16H10/60 ,  A61M1/34 ,  A61B34/10 ,  G06F21/31 ,  G08B3/10 ,  G08B5/22

CPC classification number: G16H40/60 ,  G16H10/60 ,  A61M1/3403 ,  A61B34/10 ,  H05K999/99 ,  G06F21/31 ,  G08B3/10 ,  G08B5/22 ,  A61M1/34 ,  A61M2205/3334 ,  A61M2205/33

Abstract: A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.

公开(公告)号：US11837357B2

公开(公告)日：2023-12-05

申请号：US17727476

申请日：2022-04-22

Applicant: Fenwal, Inc.

Inventor： Brian C. Case ,  Lan T. Nguyen ,  Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC: G16H40/60 ,  G16H10/60 ,  A61M1/34 ,  A61B34/10 ,  G06F21/31 ,  G08B3/10 ,  G08B5/22

CPC classification number: G16H40/60 ,  A61B34/10 ,  A61M1/34 ,  A61M1/3403 ,  G06F21/31 ,  G08B3/10 ,  G08B5/22 ,  G16H10/60 ,  H05K999/99 ,  A61M2205/33 ,  A61M2205/3334

Abstract: A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.

公开(公告)号：US20230321334A1

公开(公告)日：2023-10-12

申请号：US18130503

申请日：2023-04-04

Applicant: Fenwal, Inc.

Inventor： Samantha M. Planas ,  Kyungyoon Min ,  Amit J. Patel ,  Thomas Gniadek

IPC: A61M1/36

CPC classification number: A61M1/3693 ,  A61M2205/3379

Abstract: A blood separation device has a controller configured to execute a first and a second version of a blood separation procedure. Information regarding a blood source is analyzed to determine whether to implement the first version of the procedure or the second version. This may include an analysis of the age, weight, and/or sex of the blood source, along with whether the blood source has previously been the subject of a blood separation procedure. The second version may allow for a greater percentage of the blood or red blood cells of the blood source to be outside of the body of the blood source (in a fluid flow circuit mounted to the device) at any time during the procedure. The second version may also or alternatively allow for a higher blood cell separation efficiency than the first version, along with separating the blood in a larger blood separation chamber.