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公开(公告)号：US11478792B2
公开(公告)日：2022-10-25
申请号：US15719224
申请日：2017-09-28
申请人： Terumo BCT, Inc.
发明人： James R. Ladtkow , Dennis J. Hlavinka , Thomas J. Felt , Andrew Gloor , Jesse Janzen , Taylor Polodna , Luke Edwin Ladtkow
IPC分类号： B01L3/00 , B04B5/04 , A61M1/38 , A61M1/02 , B04B7/08 , G01N33/49 , G01N35/00 , G01N1/40 , A61M1/36 , F16K99/00 , B04B9/14
摘要： A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.
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公开(公告)号：US10704023B2
公开(公告)日：2020-07-07
申请号：US15700303
申请日：2017-09-11
申请人： Terumo BCT, Inc.
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
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公开(公告)号：US11692170B2
公开(公告)日：2023-07-04
申请号：US16915818
申请日：2020-06-29
申请人： Terumo BCT, Inc.
CPC分类号： C12N5/0641 , A61M1/0209 , A61M1/26 , A61M1/262 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3616 , A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
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公开(公告)号：US09435736B2
公开(公告)日：2016-09-06
申请号：US14014147
申请日：2013-08-29
申请人： Terumo BCT, Inc.
CPC分类号： G01N21/51 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , A61M2205/3306 , B04B13/00 , B04B2013/006 , G01N2035/00495 , A61M2202/0071
摘要： A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
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公开(公告)号：US09758764B2
公开(公告)日：2017-09-12
申请号：US14182534
申请日：2014-02-18
申请人： Terumo BCT, Inc.
CPC分类号： C12N5/0641 , A61M1/0209 , A61M1/26 , A61M1/262 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
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公开(公告)号：US20240325710A1
公开(公告)日：2024-10-03
申请号：US18606015
申请日：2024-03-15
申请人： Terumo BCT, Inc.
发明人： Dennis BEBIÉ , James R. Ladtkow , Charles L. Hake
CPC分类号： A61M39/10 , B29C67/0029
摘要： A tube opening device includes a body having a first side and a second side and including a tube-receiving cavity. The first side of the body includes a first belt system disposed on a first side of the tube-receiving cavity and a second belt system disposed on a second side of the tube-receiving cavity. The first and second belt systems are configured to apply pressure to a tube received in the tube-receiving cavity to open temporary seals and form a continuous tube.
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7.发明授权公开(公告)号：US09737898B2
公开(公告)日：2017-08-22
申请号：US14850295
申请日：2015-09-10
申请人： Terumo BCT, Inc.
发明人： Brian M. Holmes , James R. Ladtkow
IPC分类号： B04B5/04 , B04B11/04 , A61M1/36 , B01D21/26 , B01D21/30 , B01D21/34 , B04B7/08 , A61M1/30 , A61M1/38
CPC分类号： B04B11/04 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , B01D21/262 , B01D21/30 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B2005/045 , B04B2005/0471
摘要： A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.
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