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    Cartridge and centrifuge having a cartridge
    1.
    发明授权
    Cartridge and centrifuge having a cartridge 有权
    墨盒和离心机有一个墨盒

    公开(公告)号：US08992403B2

    公开(公告)日：2015-03-31

    申请号：US12602960

    申请日：2008-06-04

    申请人： Klaus-Günter Eberle ,  Roland Biset

    发明人： Klaus-Günter Eberle ,  Roland Biset

    IPC分类号： B04B7/08 ,  B04B5/04

    CPC分类号： B04B5/0428 ,  A61M1/0227 ,  A61M1/0277 ,  A61M1/3693 ,  A61M1/3698 ,  B04B2005/0435 ,  B04B2005/0478

    摘要： A cartridge (1) for accommodating blood bags (35) to be inserted into a centrifuge is used for the separation of blood components. Said cartridge (1) is provided with a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, wherein a fixture (29) for a filter (31) is provided in the product section (7), a product transport path (36) which leads from the blood bag section (5) via the fixture (29) for the filter (31) to the product section (7). The product transport path (36) coming from the blood bag section (5) leads into the fixture (29) for the filter (31) radially from the outside and from below.

    摘要翻译： 用于容纳插入离心机的血袋（35）的药筒（1）用于分离血液成分。 所述药筒（1）设有隔离壁（3），该分隔壁（3）将位于径向内侧的血袋部分（5）从位于径向外侧的产品部分（7）分开，其中用于过滤器（31）的夹具（29） 设置在产品部分（7）中的产品传送路径（36），其通过用于过滤器（31）的固定装置（29）从血袋部分（5）引导到产品部分（7）。 来自血袋部分（5）的产品传送路径（36）从外部和从下方径向地进入过滤器（31）的固定装置（29）。

    METHOD AND DEVICE FOR CENTRIFUGATION AND FILTRATION
    2.
    发明申请
    METHOD AND DEVICE FOR CENTRIFUGATION AND FILTRATION 有权
    用于离心和过滤的方法和装置

    公开(公告)号：US20140051564A1

    公开(公告)日：2014-02-20

    申请号：US14003833

    申请日：2012-03-28

    申请人： Luc Felden ,  Sebastien Jouette

    发明人： Luc Felden ,  Sebastien Jouette

    IPC分类号： B01D21/26

    CPC分类号： B01D21/262 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/18 ,  B01D63/16 ,  B01D71/34 ,  B01D2315/02 ,  B04B5/04 ,  B04B5/0407 ,  B04B2005/0435 ,  B04B2005/0478 ,  B04B2005/0485

    摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

    摘要翻译： 本发明提供了一种过滤和离心装置，其包括筒体，桶中用于容纳要处理的流体样品的容积，过滤介质，至少一个可在筒体中移动的活塞，以迫使体积中的流体通过过滤介质至 产生滤液和颗粒物质造粒的空间。 该装置是可离心的，并且所述空间位于该容积中或与该体积连通，并且优选远离过滤介质，使得该颗粒材料在该装置的离心过程中不会或至少不完全堵塞过滤介质。 本发明还提供了一种用于样品的无菌过滤的方法，包括以下步骤：将样品引入这种装置的体积中，使装置进行离心以将包含在样品中的颗粒材料在远离过滤介质的空间 并且向活塞施加力以迫使体积中的样品的流体通过过滤介质以产生滤液。 通过在离心力的影响下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。 此外，整个过程可以在相同的装置中进行，而不必去除样品用于任何中间澄清步骤。

    BLOOD BAG SYSTEM AND CASSETTE
    3.
    发明申请
    BLOOD BAG SYSTEM AND CASSETTE 审中-公开
    血液袋系统和CASSETTE

    公开(公告)号：US20110238029A1

    公开(公告)日：2011-09-29

    申请号：US13131054

    申请日：2009-11-18

    申请人： Roland Biset ,  Makoto Hirabuki

    发明人： Roland Biset ,  Makoto Hirabuki

    IPC分类号： A61M1/02

    CPC分类号： A61M1/0218 ,  A61J1/10 ,  A61M1/0227 ,  A61M1/029 ,  A61M1/3693 ,  A61M2205/12 ,  B01D21/262 ,  B04B5/0428 ,  B04B7/16 ,  B04B2005/0435 ,  B04B2005/0478

    摘要： A blood bag system includes a BC pooling bag for centrifugation of a buffy coat, a filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, a first tube connecting the BC pooling bag and an inlet of the filter, a second tube connecting the platelet preserving bag and an outlet of the filter, and a cassette to be fixed in the centrifugation and separation apparatus. The first tube and the second tube are disposed within the cassette. The cassette includes a first clamp section for closing and opening the first tube, and a second clamp section for closing and opening the second tube.

    摘要翻译： 血袋系统包括用于离心沉积蛋白的BC汇集袋，用于从BC汇集袋转移的上清液中除去白细胞的过滤器，用于保留已经通过过滤器的上清液的血小板保存袋， 连接BC汇集袋和过滤器入口的第一管，连接血小板保存袋和过滤器出口的第二管和要固定在离心分离装置中的盒。 第一管和第二管设置在盒内。 盒包括用于封闭和打开第一管的第一夹持部分和用于封闭和打开第二管的第二夹持部分。

    Apparatus and method for preparing platelet rich plasma and concentrates thereof
    4.
    发明授权
    Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
    制备富血小板血浆及其浓缩物的装置及方法

    公开(公告)号：US07824559B2

    公开(公告)日：2010-11-02

    申请号：US11342749

    申请日：2006-01-30

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： B01D21/26 ,  B01D33/00 ,  B01D35/00 ,  B01D37/00 ,  B04B1/04 ,  B04B3/00

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B04B5/0442 ,  B04B2005/0478

    摘要： A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports. The rake can comprise a longitudinal body, the center of which is secured to the rigid outlet tube. The separator-concentrator includes a valve assembly connecting the separation chamber and the concentration chamber. PRP concentrate is produced by contacting PRP with desiccated beads while the beads are stirred with a stationary rake, and rotating the concentration chamber at centrifugal speeds to separate PRP concentrate from the beads.

    摘要翻译： PRP分离器集中器，其包括壳体，分离组件和浓缩组件。 浓缩组件具有浓缩池。 轴向同心的刚性固定出口管固定到壳体并且延伸穿过分离组件到达贮槽。 分离组件附接到并定位在浓度组件上方，以形成围绕出口管可旋转的组合的分离器 - 集中器组合件。 分离组件包括分隔室，内部具有深度过滤器，该深度过滤器具有孔和通道，其尺寸适于在离心过程中接收和捕获红细胞。 浓缩室具有用于支撑干燥珠粒的底板和具有至少一个开口的屏幕的壁。 集中器可以具有直立屏幕支撑件的分布，直立屏幕支撑件具有内表面和外表面，圆柱形屏幕支撑在直立屏幕支撑件的外表面上。 固定的胎圈耙子可以固定到固定管并从其向外延伸，耙子具有与立式筛网支撑件间隔一定距离的远端。 耙子可以包括纵向主体，其中心固定到刚性出口管。 分离器集中器包括连接分离室和浓缩室的阀组件。 PRP浓缩物通过使PRP与干燥的珠粒接触而产生，同时将珠粒与固定的耙子一起搅拌，并且以离心速度旋转浓缩室以将PRP浓缩物与珠粒分离。

    Method And Apparatus For Preparing Platelet Rich Plasma And Concentrates Thereof
    6.
    发明申请
    Method And Apparatus For Preparing Platelet Rich Plasma And Concentrates Thereof 有权
    制备富血小板血浆及其浓缩物的方法和装置

    公开(公告)号：US20100206798A1

    公开(公告)日：2010-08-19

    申请号：US12772497

    申请日：2010-05-03

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： B01D15/02

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板活化和破坏PRP中存在的任何痕量红细胞 。

    Fluid concentrator
    7.
    发明授权
    Fluid concentrator 有权
    流体浓缩器

    公开(公告)号：US07740760B2

    公开(公告)日：2010-06-22

    申请号：US11932125

    申请日：2007-10-31

    申请人： Thomas Coull ,  Matthew R. Kyle ,  Louis S. Kidder

    发明人： Thomas Coull ,  Matthew R. Kyle ,  Louis S. Kidder

    IPC分类号： B01D63/02 ,  B01D24/32 ,  B01D33/00

    CPC分类号： A61M1/029 ,  A61M1/262 ,  A61M1/3496 ,  A61M1/3693 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B04B1/00 ,  B04B5/04 ,  B04B2005/0478

    摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

    摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。

    FLUID CONCENTRATOR
    9.
    发明申请
    FLUID CONCENTRATOR 有权
    流体浓缩器

    公开(公告)号：US20080173593A1

    公开(公告)日：2008-07-24

    申请号：US11932182

    申请日：2007-10-31

    申请人： Thomas Coull ,  Matthew Kyle ,  Louis S. Kidder

    发明人： Thomas Coull ,  Matthew Kyle ,  Louis S. Kidder

    IPC分类号： B01D21/26 ,  B01D21/30

    CPC分类号： A61M1/029 ,  A61M1/262 ,  A61M1/3496 ,  A61M1/3693 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B04B1/00 ,  B04B5/04 ,  B04B2005/0478

    摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

    摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。

    Fluid concentrator
    10.
    发明授权
    Fluid concentrator 有权
    流体浓缩器

    公开(公告)号：US07354515B2

    公开(公告)日：2008-04-08

    申请号：US11063142

    申请日：2005-02-22

    申请人： Thomas Coull ,  Matthew R. Kyle ,  Louis S. Kidder

    发明人： Thomas Coull ,  Matthew R. Kyle ,  Louis S. Kidder

    IPC分类号： B01D63/02 ,  B01D24/32 ,  B01D33/00

    CPC分类号： A61M1/029 ,  A61M1/262 ,  A61M1/3496 ,  A61M1/3693 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B04B1/00 ,  B04B5/04 ,  B04B2005/0478

    摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

    摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。