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公开(公告)号：US08696905B2
公开(公告)日：2014-04-15
申请号：US13219193
申请日：2011-08-26
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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公开(公告)号：US07803279B2
公开(公告)日：2010-09-28
申请号：US11932182
申请日：2007-10-31
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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公开(公告)号：US08012351B2
公开(公告)日：2011-09-06
申请号：US12817734
申请日：2010-06-17
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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公开(公告)号：US20110017669A1
公开(公告)日：2011-01-27
申请号：US12817734
申请日：2010-06-17
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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5.发明申请公开(公告)号：US20100260815A1
公开(公告)日：2010-10-14
申请号：US12666131
申请日：2008-06-20
申请人： Matthew R. Kyle , Thomas Coull
发明人： Matthew R. Kyle , Thomas Coull
IPC分类号： A61K9/00 , C12M1/00 , C12M1/34 , C12N5/071 , A61K35/12 , A61K35/14 , A61K35/16 , A61K35/22 , A61K35/37 , A61K35/26 , A61K35/48 , C12N5/078 , C12N5/077 , A61P43/00 , B01D63/00 , B01D61/20 , B01D61/14 , B01D21/26 , B01D21/02
CPC分类号： A61M1/3633 , A61K35/14 , A61K35/16 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/38 , A61K35/50 , A61K35/52 , A61M1/262 , A61M1/34 , A61M1/3693 , A61M1/3696 , A61M2202/0405 , A61M2202/0413 , A61M2202/0415 , A61M2202/0464 , A61M2202/0466 , A61M2202/0496 , A61M2202/07 , A61M2202/09 , A61M2202/10 , A61M2205/3306 , A61M2205/3331 , A61M2205/75 , B01D15/3809 , B01D15/3828 , B01D21/0012 , B01D21/262 , B01D21/34 , B01D24/007 , B01D24/10 , B01D61/246 , B01D63/02 , B01D65/00 , B01D2221/10 , B01D2313/10 , B01D2313/243 , B01D2313/50 , B01D2313/90 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： The present invention provides devices and methods for concentrating a fluid and for treating a patient with the concentrated fluid. The concentrator apparatus includes a main housing (12) defining a separation chamber (14), a filter housing (48) containing a filter (46) comprising a filter element, a piping (44) for moving concentrated fluid from the separation chamber to the filter, and ports (32) for pressurizing the concentrated fluid past the filter element of the filter. The present invention also provides a variety of uses of concentrated body fluids, including autologous concentrated body fluid. The concentrated fluids can be used for example in surgical applications, including graft applications such as allograft, xenograft and autograft applications.
摘要翻译： 本发明提供了用于浓缩流体和用于用浓缩流体治疗患者的装置和方法。 集中器装置包括限定分离室（14）的主壳体（12），包含过滤元件的过滤器（46）的过滤器壳体（48），用于将浓缩流体从分离室移动到 过滤器和端口（32），用于将浓缩的流体加压通过过滤器的过滤器元件。 本发明还提供了包括自体浓缩体液在内的浓缩体液的各种用途。 浓缩流体可用于例如外科应用，包括移植物应用，如同种异体移植物，异种移植物和自体移植物应用。
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公开(公告)号：US07740760B2
公开(公告)日：2010-06-22
申请号：US11932125
申请日：2007-10-31
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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公开(公告)号：US07354515B2
公开(公告)日：2008-04-08
申请号：US11063142
申请日：2005-02-22
申请人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew R. Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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公开(公告)号：US20080210645A1
公开(公告)日：2008-09-04
申请号：US11932125
申请日：2007-10-31
申请人： Thomas Coull , Matthew Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
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公开(公告)号：US07641677B2
公开(公告)日：2010-01-05
申请号：US10300078
申请日：2002-11-20
申请人： Lon S. Weiner , Thomas Coull
发明人： Lon S. Weiner , Thomas Coull
IPC分类号： A61B17/86
CPC分类号： A61B17/685 , A61B17/8605 , A61B17/8665
摘要： A bone fragment wire connects a bone fragment to an anchor bone for a healing duration. The bone fragment wire has a distal bone penetration section which is advanced into the bone and a proximal bone exterior section. The proximal bone exterior section is longer than the bone penetration section, and thus extends substantially out of the bone during healing of the bone. The bone penetration section includes a distal bone anchor section which threadingly engages the anchor bone, and a proximal fragment section of small diameter. The fragment section fits within the overbore created by advancing the bone anchor section through the bone fragment, and thus extends through but does not positively engage the bone fragment. A compression engagement on a distal end of the bone exterior section provides a compression shoulder. In one embodiment the compression engagement is provided by a threaded compression nut, while in another embodiment the compression engagement is permanently affixed to the bone wire. The shoulder makes substantial contact with an exterior surface of the bone fragment, biasing the bone fragment toward the anchor bone with a controlled compression force. The compression engagement is further adapted, such as through thread form and/or with a sloped proximal side, to enable the bone wire to be more easily removed from the healed fracture without damaging surrounding tissue.
摘要翻译： 骨碎片线将骨碎片连接到锚骨以达到愈合时间。 骨碎片线具有远端骨穿透部分，其进入骨骼和近端骨外部部分。 近端骨外部部分比骨穿透部分长，并且因此在骨骼愈合期间基本上延伸出骨骼。 骨穿透部分包括与锚骨螺纹接合的远端骨锚部分和小直径的近端碎片部分。 碎片部分适合于通过使骨锚固部分穿过骨片段而推进的穿孔，并因此延伸穿过但不能正确地接合骨片段。 在骨外部部分的远端上的压缩接合提供压缩肩部。 在一个实施例中，压缩接合由螺纹压紧螺母提供，而在另一实施例中，压缩接合永久地固定在骨线上。 肩部与骨片的外表面实质接触，以受控的压力将骨片偏向锚骨。 压缩接合进一步适应，例如通过螺纹形式和/或具有倾斜的近侧，以使得骨线能够更容易地从愈合的骨折移除而不损坏周围的组织。
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公开(公告)号：US20120074073A1
公开(公告)日：2012-03-29
申请号：US13219193
申请日：2011-08-26
申请人： Thomas Coull , Matthew Kyle , Louis S. Kidder
发明人： Thomas Coull , Matthew Kyle , Louis S. Kidder
CPC分类号： A61M1/029 , A61M1/262 , A61M1/3496 , A61M1/3693 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B1/00 , B04B5/04 , B04B2005/0478
摘要： A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
摘要翻译： 浓缩器用于将流体，特别是血液中的血浆成分浓缩，用于治疗患者。 集中器装置包括限定离心机室的主壳体，其也保持过滤器。 浓缩器允许在离心后观察流体，出口端口可定位在与要进一步浓缩的流体部分的水平相对应的高度处。 一旦流体被离心，一部分流体被抽出通过出口，然后压力通过过滤器，以进一步浓缩流体使用与用于离心的相同的容器。 相同的柱塞优选用于从离心机室抽取离心的流体，以将离心的流体压力通过过滤器。
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