专利检索 cpc:"A61L27/3852" 第 1 页

1.

发明公开
METHOD FOR IN-VITRO PRODUCTION OF A COHESIVE CARTILAGE CONSTRUCT 审中-公开

公开(公告)号：US20240352421A1

公开(公告)日：2024-10-24

申请号：US17753946

申请日：2020-09-18

申请人： Chondro Engineering AS

发明人： Oddmund Johannes Johansen

IPC分类号： C12N5/077 , A61L27/38

CPC分类号： C12N5/0655 , A61L27/3852 , A61L27/3895 , C12N2500/02 , C12N2513/00 , C12N2527/00

摘要： A method for in-vitro production of a cohesive cartilage construct includes the following steps: a) propagating chondrogenic cells derived from a subject to allow formation of one or more cartilage micro constructs; b) putting a plurality of the cartilage micro constructs in motion to facilitate contact between the cartilage micro constructs and thereby allow formation of one or more fused cartilage micro constructs; and c) subjecting one or more of the fused cartilage micro constructs to mechanical stimulation in a hypoxic environment to allow formation of a cohesive cartilage construct.

2.

发明公开
INJECTABLE, CROSS-LINKABLE AND SUBCELLULAR SIZE MICROFIBERS FOR SOFT TISSUE REPAIR 审中-公开

公开(公告)号：US20240033401A1

公开(公告)日：2024-02-01

申请号：US18265818

申请日：2021-12-17

申请人： Drexel University , The Children's Hospital of Philadelphia

发明人： Li-Hsin Han , Mingkun Wang , Chunxiao Cui , John Todd Lawrence , Maurizio Pacifici

IPC分类号： A61L27/26 , A61L27/56 , A61L27/38

CPC分类号： A61L27/26 , A61L27/56 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L27/3856 , A61L27/3847 , A61L2430/38 , A61L2430/06 , A61L2430/02 , A61L2400/06 , A61L2300/60

摘要： The present invention provides an injectable scaffold comprising a plurality of unclad microfibers, and a diluent solution.

3.

发明授权
Methods and compositions for repair of cartilage using an in vivo bioreactor 有权

公开(公告)号：US10052410B2

公开(公告)日：2018-08-21

申请号：US15371994

申请日：2016-12-07

申请人： SpinalCyte, LLC

发明人： Lionel C. Sevrain , Sylvie Y. Verdier-Sevrain

IPC分类号： A61L27/38 , A61F2/30 , A61F2/44 , A61F2/28

CPC分类号： A61L27/3817 , A61F2/30756 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/441 , A61F2002/2817 , A61F2002/286 , A61F2002/30062 , A61F2002/30586 , A61F2002/30677 , A61F2002/30762 , A61F2002/30764 , A61F2002/30766 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61F2002/4635 , A61F2210/0004 , A61K35/32 , A61K35/33 , A61K38/18 , A61K45/06 , A61L27/3852 , A61L27/3895 , A61L2430/06 , C12N5/0655 , C12N2500/02 , C12N2500/38 , C12N2501/155 , C12N2506/1307 , C12N2521/00 , C12N2533/74 , A61K2300/00

摘要： Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

4.

发明授权
Resilient interpositional arthroplasty device 有权

公开(公告)号：US10045851B2

公开(公告)日：2018-08-14

申请号：US15651958

申请日：2017-07-17

申请人： iOrthopedics, Inc.

发明人： Robert Thomas Grotz

IPC分类号： A61F2/38 , A61L27/54 , A61L27/58 , A61L27/34 , A61L27/38 , A61L27/56 , A61L27/18 , A61F2/30 , A61B17/064

CPC分类号： A61F2/3859 , A61B17/0642 , A61B17/562 , A61B2017/561 , A61F2/30756 , A61F2/3872 , A61F2002/30062 , A61F2002/30563 , A61F2002/30578 , A61F2002/30581 , A61F2002/30688 , A61F2002/30754 , A61F2002/3863 , A61L27/18 , A61L27/34 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2300/64 , A61L2400/10 , A61L2430/06 , A61L2430/24 , C08L75/04 , C08L67/04

摘要： This disclosure is directed to restoring joints by deploying a resilient interpositional arthroplasty implant. Such implants function to pad cartilage defects, cushion, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. The walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability so as to enable immediate limb use after outpatient surgery. Appendages of the implant may repair or reconstruct tendons or ligaments, and menisci by interpositional inflatable or compliant polymer arthroplasties that promote anatomic joint motion.

5.

发明申请
Glycosaminoglycan Compositions and Methods for Treating Connective Tissue Damage 审中-公开

公开(公告)号：US20180221413A1

公开(公告)日：2018-08-09

申请号：US15928509

申请日：2018-03-22

申请人： ARTHRODYNAMIC HOLDINGS, LLC

发明人： Frank D. Marcum

IPC分类号： A61K35/28 , A61K31/728

CPC分类号： A61K35/28 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61K31/715 , A61K31/728 , A61K35/35 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/27 , A61K38/30 , A61K45/06 , A61L27/26 , A61L27/34 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L2300/41 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2400/06 , C08L5/08 , A61K2300/00

摘要： A pharmaceutical preparation and method for treating connective tissue damage in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a glycosaminoglycan composition comprising chondroitin sulfate, hyaluronan, and N-acetyl D-glucosamine, wherein the connective tissue is skin.

6.

发明授权
Glycosaminoglycan compositions in combination with stem cells 有权

公开(公告)号：US09937209B2

公开(公告)日：2018-04-10

申请号：US14941754

申请日：2015-11-16

申请人： ArthroDynamic Technologies, Animal Health Division, Inc.

发明人： Frank D. Marcum , James Conway

IPC分类号： A61K31/728 , A61K35/28 , A61K45/06 , A61K31/715 , A61K38/18 , A61L27/26 , A61K35/35 , A61L27/34 , A61L27/38 , A61L27/54 , A61K38/27 , A61K38/30 , A61B17/06 , A61B17/064 , A61B17/00

CPC分类号： A61K35/28 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61K31/715 , A61K31/728 , A61K35/35 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/27 , A61K38/30 , A61K45/06 , A61L27/26 , A61L27/34 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L2300/41 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2400/06 , C08L5/08 , A61K2300/00

摘要： A pharmaceutical preparation for treating connective tissue damage in man and in animals, comprising a therapeutically effective amount of a glycosaminoglycan composition comprising chondroitin sulfate and hyaluronan, in combination with isolated stem cells. Methods of use and kits containing the glycosaminoglycan composition and materials for isolating stem cells and for treating connective tissue damage and repair of cartilage in man and in animals are also provided.

7.

发明申请
STEM CELL-BASED TECHNOLOGIES FOR AVIAN SKELETAL TISSUE ENGINEERING AND REGENERATION 审中-公开

公开(公告)号：US20170333488A1

公开(公告)日：2017-11-23

申请号：US15525570

申请日：2015-11-04

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Rocky S. TUAN

IPC分类号： A61K35/57 , A61L27/22 , A61L27/52 , A61L27/38 , A61K47/32 , A61K47/42

CPC分类号： A61K35/57 , A61K9/06 , A61K47/32 , A61K47/42 , A61L27/16 , A61L27/222 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/52 , A61L2300/64 , A61L2430/02 , A61L2430/06 , C08L5/08

摘要： Methods are disclosed for forming bone and/or cartilage in an avian subject. The methods include administering to the avian subject a therapeutically effective amount of a composition comprising avian mesenchymal stem cells and a hydrogel that supports the differentiation of the avian mesenchymal stem cells into cells of an osteogenic and/or condrogenic lineage. In some embodiments, methods are disclosed for repairing a bone defect and preventing infection, such as that associated bone fracture, in an avian subject. The methods include administering locally to the bone defect a composition comprising a therapeutically effective amount of avian mesenchymal stem cells and a hydrogel, such as a methacrylated gelatin hydrogel.

8.

发明授权
Chondrocyte-like cell, and method for producing same 有权

公开(公告)号：US09725737B2

公开(公告)日：2017-08-08

申请号：US13926183

申请日：2013-06-25

申请人： iPS ACADEMIA JAPAN, INC.

发明人： Noriyuki Tsumaki

IPC分类号： C12N5/00 , C12N5/02 , C12N15/85 , A61K31/713 , A61L27/38 , C12N5/077 , A61K35/32 , A61K49/00 , A61K35/12

CPC分类号： C12N15/85 , A61K31/713 , A61K35/12 , A61K35/32 , A61K49/0004 , A61L27/3817 , A61L27/3852 , C12N5/0655 , C12N2501/60 , C12N2510/00

摘要： Disclosed is a cell which enables the reproduction of a cartilage tissue and has a proliferative ability. Also disclosed is a technique for providing a cell supply source which can be used in a definitive treatment of osteochondrosis deformans. A chondrocyte-like cell which has the same properties as those of a chondrocyte and can proliferate can be produced by selecting a combination of an Myc family gene and/or a Klf family gene and a SOX9 gene and introducing the combination into a somatic cell. The chondrocyte-like cell can be used for a medical purpose of cartilage regeneration.