公开(公告)号：US10052410B2

公开(公告)日：2018-08-21

申请号：US15371994

申请日：2016-12-07

Applicant: SpinalCyte, LLC

Inventor： Lionel C. Sevrain ,  Sylvie Y. Verdier-Sevrain

IPC: A61L27/38 ,  A61F2/30 ,  A61F2/44 ,  A61F2/28

CPC classification number: A61L27/3817 ,  A61F2/30756 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/40 ,  A61F2/441 ,  A61F2002/2817 ,  A61F2002/286 ,  A61F2002/30062 ,  A61F2002/30586 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61K35/32 ,  A61K35/33 ,  A61K38/18 ,  A61K45/06 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/155 ,  C12N2506/1307 ,  C12N2521/00 ,  C12N2533/74 ,  A61K2300/00

Abstract: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

公开(公告)号：US09981063B2

公开(公告)日：2018-05-29

申请号：US11286593

申请日：2005-11-23

Applicant: Shawn W. O'Driscoll ,  David G. Lewallen ,  Rodrigo Mardones

Inventor： Shawn W. O'Driscoll ,  David G. Lewallen ,  Rodrigo Mardones

IPC: A61F2/28 ,  A61L27/36 ,  A61F2/30 ,  A61L27/42 ,  A61L27/56 ,  A61F2/46

CPC classification number: A61L27/3683 ,  A61F2/30756 ,  A61F2/468 ,  A61F2002/2817 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2310/00131 ,  A61F2310/00365 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/427 ,  A61L27/56

Abstract: A composite for osteochondral defect repair includes a porous scaffold and a periosteal graft secured to a surface of the scaffold. The composite provides cartilage growth from autologous periosteum chondrogenesis. Biological resurfacing of large osteochondral defects, or a complete joint is feasible using the porous scaffold/autologous periosteal composite. The use of this composite eliminates the necessity of using normal cartilage surface as a donor site and its respective associated morbidity. In one form, the strong bone integration capacity of a porous metal (e.g., tantalum) scaffold and the high grade of integration observed from periosteal chondrogenesis into the normal cartilage eliminates the lack of chondral-chondral integration observed in the autologous osteochondral graft technique.

公开(公告)号：US09744043B2

公开(公告)日：2017-08-29

申请号：US11826518

申请日：2007-07-16

Applicant: Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, Jr.

Inventor： Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, Jr.

IPC: A61F2/28 ,  A61F2/30 ,  A61B17/16 ,  A61F2/46 ,  A61L27/36 ,  A61L27/38 ,  A61F2/38

CPC classification number: A61F2/30756 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/1675 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/4646 ,  A61F2002/4648 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3804 ,  A61L2430/06

Abstract: The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.

公开(公告)号：US20150351916A1

公开(公告)日：2015-12-10

申请号：US14646263

申请日：2015-02-04

Applicant: FRANK J. KOSAREK ,  Michelle J. Rivera ,  Frank J. Kosarek

Inventor： FRANK J. KOSAREK ,  Michelle J. Rivera ,  Frank J. Kosarek

IPC: A61F2/30 ,  A61B17/17 ,  A61B8/08 ,  A61B10/02 ,  A61B5/055 ,  A61B6/03 ,  A61B17/88 ,  A61F2/46

CPC classification number: A61F2/30942 ,  A61B5/055 ,  A61B6/032 ,  A61B8/0875 ,  A61B10/025 ,  A61B17/1764 ,  A61B17/1767 ,  A61B17/1771 ,  A61F2/30756 ,  A61F2/4618 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30948 ,  A61F2002/30985

Abstract: A process for fabricating size-specific, customized bio-printed musculoskeletal tissue using three dimensional data collected from radiologic imaging is provided. Also, provided is a guide that is created from radiological imaging that demarcates the area of surgical interest. The guide is 3D printed according to guide dimensions collected from radiological imaging, including, but not limited to, CT imaging scans, CT arthrography, ultrasound, MRI, MR arthrography, or any other imaging modality used to image the musculoskeletal system.

Abstract translation: 提供了使用从放射学成像收集的三维数据来制造尺寸特异性，定制的生物印刷肌肉骨骼组织的方法。 另外，提供了从放射学成像创建的指南，其区分手术感兴趣的区域。 该指南根据从放射成像收集的指导尺寸进行3D打印，包括但不限于CT成像扫描，CT关节造影术，超声，MRI，MR关节造影术或用于对肌肉骨骼系统进行成像的任何其他成像模式。

公开(公告)号：US20150105696A1

公开(公告)日：2015-04-16

申请号：US14401589

申请日：2013-05-23

Applicant: Accelerated Orthopedic Technologies, Inc.

Inventor： Ronald G. Litke ,  Ernest Corrao

IPC: A61F2/30 ,  A61B17/16 ,  A61F2/46 ,  A61B5/107 ,  A61B5/00

CPC classification number: A61F2/30756 ,  A61B5/1077 ,  A61B5/4836 ,  A61B5/742 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/1764 ,  A61F2/4644 ,  A61F2/4657 ,  A61F2002/2835 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/30764 ,  A61F2002/30962 ,  A61F2002/4649 ,  A61F2002/4663

Abstract: Exemplary embodiments are directed to instruments, methods and systems for harvesting and implanting graft materials, including instruments for capturing a surface topography of an anatomical location, instruments for defining an implant region, and graft harvesting devices. Exemplary embodiments are also directed to methods for capturing a surface topography of an anatomical location, methods for defining an implant region, and methods for harvesting a donor plug. The exemplary instruments, methods and systems generally include capturing a surface topography of a defect region, creating a defect region cavity, and harvesting a donor plug configured and dimensioned to be implanted in the defect region cavity.

Abstract translation: 示例性实施例涉及用于收获和植入移植材料的仪器，方法和系统，包括用于捕获解剖位置的表面形貌的仪器，用于限定植入区域的器械和移植物收获装置。 示例性实施例还涉及用于捕获解剖位置的表面形貌的方法，用于限定植入区域的方法以及用于收获供体塞的方法。 示例性的仪器，方法和系统通常包括捕获缺陷区域的表面形貌，产生缺陷区域空腔，以及收获被配置和定尺寸为被注入缺陷区域空腔中的供体塞。

公开(公告)号：US08784863B2

公开(公告)日：2014-07-22

申请号：US12976704

申请日：2010-12-22

Applicant: Neil Kizer ,  Robert Spiro ,  Jian Yao ,  Cheryl Renee Blanchard

Inventor： Neil Kizer ,  Robert Spiro ,  Jian Yao ,  Cheryl Renee Blanchard

IPC: A61F2/02

CPC classification number: A61L27/3683 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61F2310/00377 ,  A61K35/32 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3817 ,  A61L27/3852 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2533/56 ,  C12N2533/80

Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Abstract translation: 本发明涉及具有至少一种新软骨颗粒，幼体软骨颗粒或其组合和基质的组合物，以及包含该组合物的方法和装置。

公开(公告)号：US08221500B2

公开(公告)日：2012-07-17

申请号：US12179034

申请日：2008-07-24

Applicant: Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W Tomford

Inventor： Katherine Gomes Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W Tomford

IPC: A61F2/28

CPC classification number: A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30136 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/3024 ,  A61F2002/30299 ,  A61F2002/30327 ,  A61F2002/30764 ,  A61F2002/30785 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0069 ,  A61F2230/0093 ,  A61F2250/0014 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3852 ,  A61L2430/06

Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.

Abstract translation: 本发明涉及一种软骨修复组件，其包括软骨下骨的成形同种异体移植结构，其具有整体的上覆软骨帽，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和铣碎的同种异体移植软骨。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得成形骨或软骨盖以过盈配合接合钻孔的侧壁并与研磨的软骨和生物相容性载体混合物接触 允许细胞转移到整个缺陷区域。 还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。

公开(公告)号：US20110275151A1

公开(公告)日：2011-11-10

申请号：US13185472

申请日：2011-07-18

Applicant: Lionel C. Sevrain ,  Sylvie Y. Verdier-Sevrain

Inventor： Lionel C. Sevrain ,  Sylvie Y. Verdier-Sevrain

IPC: C12N5/071

CPC classification number: A61L27/3817 ,  A61F2/30756 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/40 ,  A61F2/441 ,  A61F2002/2817 ,  A61F2002/286 ,  A61F2002/30062 ,  A61F2002/30586 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61K35/32 ,  A61K35/33 ,  A61K38/18 ,  A61K45/06 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/155 ,  C12N2506/1307 ,  C12N2521/00 ,  C12N2533/74 ,  A61K2300/00

Abstract: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

Abstract translation: 描述了使用结合惰性结构和活性核的混合构建体来软骨生物修复的方法和组合物。 惰性结构不仅用作用于饲养和生长活性核心组分的递送系统，而且还用作细胞分化的诱导剂。 惰性结构包括同心的内部和外部和可充气/可膨胀的气球样生物聚合物。 生物核心包括由HDF组成的细胞 - 基质构建体，例如，种植在支架中。 该方法包括从患者手术切除损伤的软骨，并将混合构建体插入到上述外科手术后产生的空腔中。 惰性结构的气囊在目标区域内连续膨胀，例如接头。 本文还公开了通过机械应变将人成纤维细胞生长和分化成软骨细胞样细胞的方法。

公开(公告)号：US07959636B2

公开(公告)日：2011-06-14

申请号：US10638489

申请日：2003-08-12

Applicant: Reinhold Schmieding

Inventor： Reinhold Schmieding

IPC: A61F2/46

CPC classification number: A61F2/30756 ,  A61B17/025 ,  A61B17/1615 ,  A61B17/1635 ,  A61B17/1675 ,  A61B2090/061 ,  A61B2090/062 ,  A61F2/3859 ,  A61F2/4618 ,  A61F2/4657 ,  A61F2002/2839 ,  A61F2002/30224 ,  A61F2002/30617 ,  A61F2002/30764 ,  A61F2002/4627 ,  A61F2002/4659 ,  A61F2002/4662 ,  A61F2002/4681 ,  A61F2230/0069 ,  A61F2250/0097 ,  A61L27/16 ,  A61L27/52 ,  C08L29/04

Abstract: A method and apparatus for repairing isolated chondral defects using synthetic implants. Lesions in articular tissue are corrected by forming a recipient socket in the tissue. A donor graft of a size corresponding to the recipient socket is harvested from a synthetic specimen made of a synthetic tissue material, such as poly (vinyl) alcohol hydrogel. The donor graft is implanted into the recipient socket.

Abstract translation: 使用合成植入物修复孤立软骨缺损的方法和装置。 通过在组织中形成受体插管来校正关节组织中的损伤。 从由合成组织材料如聚（乙烯基）醇水凝胶制成的合成样品中收获与受体插座对应的尺寸的供体移植物。 供体移植物植入受体插座。

公开(公告)号：US07837740B2

公开(公告)日：2010-11-23

申请号：US11657042

申请日：2007-01-24

Applicant: Eric J. Semler ,  Katherine G. Truncale ,  Alex B. Callahan ,  Judith I. Yannariello-Brown

Inventor： Eric J. Semler ,  Katherine G. Truncale ,  Alex B. Callahan ,  Judith I. Yannariello-Brown

IPC: A61F2/28

CPC classification number: A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30354 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/30932 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/06

Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.

Abstract translation: 本发明涉及一种软骨修复组件，其包括具有软化松质骨的成形同种异体移植两片构件和定义具有与盲孔相交的穿过横向孔的盲孔的矿化圆柱形基底构件。 脱矿质松质骨盖具有圆柱形顶部和较小直径的圆柱形杆，其远离顶部部分延伸，该顶部配合到矿化基底的盲孔中。 盖杆限定横向通孔，其与基部构件的通孔对齐，以容纳将盖保持在基部构件内的圆柱形皮质销。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得组件以过盈配合接合钻孔的侧壁。