专利检索 ap:("P. Mickey Williams" OR "Mary Gerritsen") AND inv:"P. Mickey Williams" 第 1 页

1.

发明申请
Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs 审中-公开
标题翻译：通过肿瘤坏死因子配体/受体同系物促进或抑制血管生成和心血管化

公开(公告)号：US20050202008A1

公开(公告)日：2005-09-15

申请号：US11032294

申请日：2005-01-10

申请人： P. Mickey Williams , Mary Gerritsen

发明人： P. Mickey Williams , Mary Gerritsen

IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07K14/47 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574

CPC分类号： G01N33/566 , A61K38/177 , C07K14/47 , C07K2319/30 , C12N2799/026 , G01N2333/525 , G01N2333/70575 , G01N2333/70578

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.

摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。

2.

发明申请
Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开

公开(公告)号：US20050124789A9

公开(公告)日：2005-06-09

申请号：US09978824

申请日：2001-10-16

申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood

发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood

IPC分类号： A61K31/17 , A61K38/00 , A61K38/17 , A61K38/43 , A61K39/395 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/40 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/68

CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

3.

发明申请
IL-17 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： IL-17同种异体多肽及其治疗用途

公开(公告)号：US20120064073A1

公开(公告)日：2012-03-15

申请号：US13270006

申请日：2011-10-10

申请人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura

发明人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura

IPC分类号： A61K39/395 , A61P19/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P37/08 , A61P29/00 , A61P1/00

CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

4.

发明申请
COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES 审中-公开

公开(公告)号：US20110245090A1

公开(公告)日：2011-10-06

申请号：US13046485

申请日：2011-03-11

申请人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu

发明人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu

IPC分类号： C40B30/00 , C12Q1/68 , G01N33/566

CPC分类号： C12Q1/6837 , C07K14/47 , C12N9/2417 , C12Y302/01001 , G01N33/53 , G01N33/564 , G01N33/6893 , G01N2800/24

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

5.

发明申请
Compositions and methods for the treatment of immune related diseases 审中-公开
标题翻译：用于治疗免疫相关疾病的组合物和方法

公开(公告)号：US20100166761A1

公开(公告)日：2010-07-01

申请号：US12585666

申请日：2009-09-21

申请人： Sarah C. Bodary-Winter , Hilary Clark , Brisdell Hunte , Janet K. Jackman , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu

发明人： Sarah C. Bodary-Winter , Hilary Clark , Brisdell Hunte , Janet K. Jackman , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu

IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , A61P37/00 , A61K39/00

CPC分类号： C07K14/525 , C07K14/47 , C07K16/18 , C07K16/28 , C12Q1/6883 , C12Q2600/158 , G01N2800/24 , Y02A90/24

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。

6.

发明申请
IL-17 homologous polypeptides and therapeutic uses thereof 审中-公开

公开(公告)号：US20090291097A1

公开(公告)日：2009-11-26

申请号：US11802794

申请日：2007-05-25

申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

IPC分类号： A61K39/395 , C07K16/18 , A61P37/00

CPC分类号： C07K14/54 , A61K38/00

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

7.

发明申请
NUCLEIC ACIDS ENCODING RECEPTOR FOR IL-17 HOMOLOGOUS POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译： IL-17同种异体多核苷酸编码受体的核酸及其用途

公开(公告)号：US20090227017A1

公开(公告)日：2009-09-10

申请号：US12417097

申请日：2009-04-02

申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

IPC分类号： C12N5/06 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/16

CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

8.

发明申请
IL-17 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 有权
标题翻译： IL-17同种异体多肽及其治疗用途

公开(公告)号：US20090227016A1

公开(公告)日：2009-09-10

申请号：US12412796

申请日：2009-03-27

申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Collin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Collin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura

IPC分类号： C12N5/10 , C12N1/21 , C12N1/19 , C12N15/63 , C07H21/04

CPC分类号： C07K14/54 , A61K38/00 , C07K14/7155 , C07K2319/30 , C12N2510/00 , G01N33/6869 , G01N2500/04 , G01N2800/24

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。