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    LATERAL FLOW ASSAY DEVICE
    6.
    发明申请
    LATERAL FLOW ASSAY DEVICE 审中-公开
    侧流测试装置

    公开(公告)号：US20160041163A1

    公开(公告)日：2016-02-11

    申请号：US14819893

    申请日：2015-08-06

    申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

    发明人： Zhong Ding ,  Philip C. Hosmier ,  Edward R. Scalice ,  Daniel P. Salotto ,  David A. Heavner

    IPC分类号： G01N33/558 ,  G01N33/536 ,  G01N21/77 ,  G01N33/53

    CPC分类号： G01N33/558 ,  G01N21/77 ,  G01N33/5306 ,  G01N33/536 ,  G01N33/54366 ,  G01N2021/7763

    摘要： A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics.

    摘要翻译： 侧流测定装置包括具有顶表面的基底以及设置在顶表面上的样品接收区域。 至少一个流体流动路径沿着基底从样品接收区域延伸，其中样品接收区域可以放置成与在样品添加区域形成的外围储存器接触，以受控的方式从中抽出样品。 该装置还可以包括试剂区域，该试剂区域被设计成促进通过沿着流体流动路径移动通过装置的样品沉积的检测材料的均匀溶解，作为构造为促进样品和试剂的混合的流动通道和吸收 或芯吸区配置成影响各种流动特性。

    Assay device having uniform flow around corners
    7.
    发明授权
    Assay device having uniform flow around corners 有权
    分析装置在角落周围均匀流动

    公开(公告)号：US08895293B2

    公开(公告)日：2014-11-25

    申请号：US13744451

    申请日：2013-01-18

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

    IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N33/543

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

    摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

    摘要翻译： 测定装置包括：液体样品区; 下游的试剂区并与含有试剂材料的样品区流体连通; 检测区，其与具有与其结合的捕获元件的试剂区流体连通; 以及与捕获区流体连通的吸收区，其具有接收从检测区流动的液体样品的能力。 样品接收区域，试剂区域，检测区域和芯吸区域限定了流体流动路径，并且流体流动路径的至少一部分具有基底和基本上垂直于基底延伸的突起，其中突起具有高度 ，横截面和彼此之间的距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。 此外，具有突起的流体流路包括改变流路方向的角部。 修改拐角部分中或周围的突出部分，以便在角部与拐角之前基本相同的构造下，保持样品流动前沿的结构流过流路。