公开(公告)号：US20160018394A1

公开(公告)日：2016-01-21

申请号：US14333571

申请日：2014-07-17

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： Susan Danielson ,  James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  James W. Hassett ,  Timothy C. Warren ,  David A. Heavner

IPC分类号： G01N33/543

CPC分类号： G01N33/54386 ,  G01N33/54306 ,  G01N33/558

摘要： An assay device for determining the concentration of multiple analytes or controls, where the device is capable of determining the presence or concentration of at least six analytes or controls includes: a fluid flow path; a liquid sample addition zone; a reagent zone downstream and in fluid communication with the sample addition zone containing one or more reagents; multiple detection zones in fluid communication with the reagent zone. The fluid flow path, which extends through the detection zones, has a length capable of having at least six detection zones linearly spaced at least a sufficient distance apart in order to discriminate each signal peak from its adjacent signal peak. The device further includes a wicking zone in fluid communication with the detection zones having a capacity to receive liquid sample flowing from the detection zone. The fluid flow path extends from the sample zone to the wicking zone, and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate. The projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface.

摘要翻译： 用于确定多个分析物或对照物的浓度的测定装置，其中所述装置能够确定至少六种分析物或对照物的存在或浓度包括：流体流动路径; 液体样品添加区; 下游的试剂区并与含有一种或多种试剂的样品添加区流体连通; 多个检测区与试剂区流体连通。 延伸穿过检测区域的流体流路具有能够具有至少六个检测区域的长度，该检测区域至少间隔足够的距离，以便将每个信号峰值与其相邻信号峰值区分开。 该装置还包括与检测区流体连通的芯吸区，其具有接收从检测区流动的液体样品的能力。 流体流动路径从样品区域延伸到芯吸区域，并且流体流动路径的至少一部分具有基底和从基底基本垂直延伸的突起。 突起具有彼此之间的高度，横截面和距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。

公开(公告)号：US10082502B2

公开(公告)日：2018-09-25

申请号：US15016585

申请日：2016-02-05

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/558 ,  B01L3/00 ,  G01N33/543

CPC分类号： G01N33/558 ,  B01L3/50273 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54366

摘要： An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample.

公开(公告)号：US08895293B2

公开(公告)日：2014-11-25

申请号：US13744451

申请日：2013-01-18

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N33/543

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

摘要翻译： 测定装置包括：液体样品区; 下游的试剂区并与含有试剂材料的样品区流体连通; 检测区，其与具有与其结合的捕获元件的试剂区流体连通; 以及与捕获区流体连通的吸收区，其具有接收从检测区流动的液体样品的能力。 样品接收区域，试剂区域，检测区域和芯吸区域限定了流体流动路径，并且流体流动路径的至少一部分具有基底和基本上垂直于基底延伸的突起，其中突起具有高度 ，横截面和彼此之间的距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。 此外，具有突起的流体流路包括改变流路方向的角部。 修改拐角部分中或周围的突出部分，以便在角部与拐角之前基本相同的构造下，保持样品流动前沿的结构流过流路。

公开(公告)号：US20160153982A1

公开(公告)日：2016-06-02

申请号：US15016585

申请日：2016-02-05

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/558 ,  G01N33/543

CPC分类号： G01N33/558 ,  B01L3/50273 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54366

摘要： An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample.

公开(公告)号：US20130189796A1

公开(公告)日：2013-07-25

申请号：US13744451

申请日：2013-01-18

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Phillip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N1/28

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

公开(公告)号：US09625457B2

公开(公告)日：2017-04-18

申请号：US14540221

申请日：2014-11-13

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N1/28

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

公开(公告)号：US20150153338A1

公开(公告)日：2015-06-04

申请号：US14578689

申请日：2014-12-22

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： Philip C. Hosimer ,  Zhong Ding ,  David A. Heavner ,  Edward R. Scalice ,  Susan Danielson ,  James D. Kanaley ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54366 ,  B01L3/50 ,  B01L3/502 ,  B01L2400/0406 ,  G01N33/558 ,  G01N2333/58 ,  G01N2333/585

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface. The device is capable of creating a reagent plume in the detection zone that includes liquid sample and dissolved reagent, where the width of the reagent plume extends substantially across the width of the detection zone, The device further includes a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone.

摘要翻译： 测定装置包括：液体样品区; 试剂区下游并与含有试剂材料的样品添加区流体连通; 与试剂区流体连通的检测区域。 检测区域具有基板和从基板基本上垂直延伸的突起，其中突起具有彼此之间的高度，横截面和距离，其限定能够产生平行于基板表面的毛细管流的突起之间的毛细管空间 。 该装置能够在包括液体样品和溶解试剂的检测区域中产生试剂羽流，其中试剂羽流的宽度基本上在检测区域的宽度上延伸。该装置还包括与该检测区流体连通的芯吸区域 检测区具有接收从检测区流出的液体样品的能力。

公开(公告)号：US20150153337A1

公开(公告)日：2015-06-04

申请号：US14540221

申请日：2014-11-13

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

摘要翻译： 测定装置包括：液体样品区; 下游的试剂区并与含有试剂材料的样品区流体连通; 检测区，其与具有与其结合的捕获元件的试剂区流体连通; 以及与捕获区流体连通的吸收区，其具有接收从检测区流动的液体样品的能力。 样品接收区域，试剂区域，检测区域和芯吸区域限定了流体流动路径，并且流体流动路径的至少一部分具有基底和基本上垂直于基底延伸的突起，其中突起具有高度 ，横截面和彼此之间的距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。 此外，具有突起的流体流路包括改变流路方向的角部。 修改拐角部分中或周围的突出部分，以便在角部与拐角之前基本相同的构造下，保持样品流动前沿的结构流过流路。

公开(公告)号：US20140206098A1

公开(公告)日：2014-07-24

申请号：US13744617

申请日：2013-01-18

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： Philip C. Hosimer ,  Zhong Ding ,  David A. Heavner ,  Edward R. Scalice ,  Susan Danielson ,  James D. Kanaley ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/53

CPC分类号： G01N33/54366 ,  B01L3/50 ,  B01L3/502 ,  B01L2400/0406 ,  G01N33/558 ,  G01N2333/58 ,  G01N2333/585

摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface. The device is capable of creating a reagent plume in the detection zone that includes liquid sample and dissolved reagent, where the width of the reagent plume extends substantially across the width of the detection zone, The device further includes a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone.

摘要翻译： 测定装置包括：液体样品区; 试剂区下游并与含有试剂材料的样品添加区流体连通; 与试剂区流体连通的检测区域。 检测区域具有基板和从基板基本上垂直延伸的突起，其中突起具有彼此之间的高度，横截面和距离，其限定能够产生平行于基板表面的毛细管流的突起之间的毛细管空间 。 该装置能够在包括液体样品和溶解试剂的检测区域中产生试剂羽流，其中试剂羽流的宽度基本上在检测区域的宽度上延伸。该装置还包括与该检测区流体连通的芯吸区域 检测区具有接收从检测区流出的液体样品的能力。

公开(公告)号：US20130210036A1

公开(公告)日：2013-08-15

申请号：US13744641

申请日：2013-01-18

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

IPC分类号： G01N33/543

CPC分类号： G01N33/558 ,  B01L3/50273 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54366

摘要： An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample.

摘要翻译： 测定装置包括：检测区，其包括能够产生毛细管流的第一组突起。 芯吸区（WZ）具有接收从检测区流出的液体样品的能力，并且包括能够产生毛细管流的第二组突起。 WZ的形状为矩形，矩形的较长边沿流动方向延伸，从而降低了测定装置中的压力梯度，与具有相同长度的边和相同体积的WZ相比，液体样品的总流动时间增加。 第二组突起的至少一部分具有从直径，中心到中心间隔或与第一组突起不同的突起之间的间隙中选择的至少一个尺寸，并且被选择以增加总数 样品流动时间。