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    Assay Device Having Uniform Flow Around Corners
    4.
    发明申请
    Assay Device Having Uniform Flow Around Corners 有权

    公开(公告)号：US20130189796A1

    公开(公告)日：2013-07-25

    申请号：US13744451

    申请日：2013-01-18

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： James D. Kanaley ,  Zhong Ding ,  Phillip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

    IPC分类号： G01N1/28

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

    摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

    Assay device having uniform flow around corners
    6.
    发明授权
    Assay device having uniform flow around corners 有权
    分析装置在角落周围均匀流动

    公开(公告)号：US08895293B2

    公开(公告)日：2014-11-25

    申请号：US13744451

    申请日：2013-01-18

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

    IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N33/543

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

    摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.

    摘要翻译： 测定装置包括：液体样品区; 下游的试剂区并与含有试剂材料的样品区流体连通; 检测区，其与具有与其结合的捕获元件的试剂区流体连通; 以及与捕获区流体连通的吸收区，其具有接收从检测区流动的液体样品的能力。 样品接收区域，试剂区域，检测区域和芯吸区域限定了流体流动路径，并且流体流动路径的至少一部分具有基底和基本上垂直于基底延伸的突起，其中突起具有高度 ，横截面和彼此之间的距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。 此外，具有突起的流体流路包括改变流路方向的角部。 修改拐角部分中或周围的突出部分，以便在角部与拐角之前基本相同的构造下，保持样品流动前沿的结构流过流路。

    Assay Device Having Multiplexing
    7.
    发明申请
    Assay Device Having Multiplexing 审中-公开
    具有复用的测定装置

    公开(公告)号：US20160018394A1

    公开(公告)日：2016-01-21

    申请号：US14333571

    申请日：2014-07-17

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： Susan Danielson ,  James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  James W. Hassett ,  Timothy C. Warren ,  David A. Heavner

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54386 ,  G01N33/54306 ,  G01N33/558

    摘要： An assay device for determining the concentration of multiple analytes or controls, where the device is capable of determining the presence or concentration of at least six analytes or controls includes: a fluid flow path; a liquid sample addition zone; a reagent zone downstream and in fluid communication with the sample addition zone containing one or more reagents; multiple detection zones in fluid communication with the reagent zone. The fluid flow path, which extends through the detection zones, has a length capable of having at least six detection zones linearly spaced at least a sufficient distance apart in order to discriminate each signal peak from its adjacent signal peak. The device further includes a wicking zone in fluid communication with the detection zones having a capacity to receive liquid sample flowing from the detection zone. The fluid flow path extends from the sample zone to the wicking zone, and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate. The projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface.

    摘要翻译： 用于确定多个分析物或对照物的浓度的测定装置，其中所述装置能够确定至少六种分析物或对照物的存在或浓度包括：流体流动路径; 液体样品添加区; 下游的试剂区并与含有一种或多种试剂的样品添加区流体连通; 多个检测区与试剂区流体连通。 延伸穿过检测区域的流体流路具有能够具有至少六个检测区域的长度，该检测区域至少间隔足够的距离，以便将每个信号峰值与其相邻信号峰值区分开。 该装置还包括与检测区流体连通的芯吸区，其具有接收从检测区流动的液体样品的能力。 流体流动路径从样品区域延伸到芯吸区域，并且流体流动路径的至少一部分具有基底和从基底基本垂直延伸的突起。 突起具有彼此之间的高度，横截面和距离，其限定能够产生平行于衬底表面的毛细管流的突起之间的空间。

    Assay Device Having Controllable Sample Size
    8.
    发明申请
    Assay Device Having Controllable Sample Size 审中-公开
    具有可控样品量的测定装置

    公开(公告)号：US20130189673A1

    公开(公告)日：2013-07-25

    申请号：US13744543

    申请日：2013-01-18

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： Edward R. Scalice ,  Philip C. Hosimer ,  Zhong Ding ,  James D. Kanaley ,  David A. Tomasso ,  Daniel P. Salotto ,  Timothy C. Warren

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5302 ,  G01N33/53 ,  G01N33/54386 ,  G01N33/558

    摘要： Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.

    摘要翻译： 公开了一种测定装置，其包括液体样品加入区，试剂区，检测区和芯吸区，均定义流体流动路径。 该装置还包括沿着样品添加区的下游和检测区的上游与流体流动路径流体连通的试剂添加区。 根据本发明的方法在该试剂添加区加入中断洗涤液以控制样品体积。 中断洗涤液以芯片装置上的预定填充体积加入，并且还用于清洗检测通道并填充剩余的芯片体积。

    Assay device having uniform flow around corners
    10.
    发明授权
    Assay device having uniform flow around corners 有权

    公开(公告)号：US09625457B2

    公开(公告)日：2017-04-18

    申请号：US14540221

    申请日：2014-11-13

    申请人： Ortho-Clinical Diagnostics, Inc.

    发明人： James D. Kanaley ,  Zhong Ding ,  Philip C. Hosimer ,  Edward R. Scalice ,  Susan Danielson ,  David A. Tomasso ,  Timothy C. Warren

    IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N1/28

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/086 ,  G01N1/28 ,  Y10T436/2575

    摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone containing a reagent material; a detection zone in fluid communication with the reagent zone having capture elements bound thereto; and a wicking zone in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the detection zone. The sample receiving zone, the reagent zone, the detection zone and the wicking zone define a fluid flow path and at least a part of the fluid flow path has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a space between the projections capable of generating capillary flow parallel to the substrate surface. In addition, the fluid flow path having projections includes a corner section which changes the direction of the flow path. The projections in or around the corner section are modified to maintain the configuration of the flow front of the sample flowing through the flow path after the corner is substantially the same configuration as before the corner.