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公开(公告)号：US20220128808A1
公开(公告)日：2022-04-28
申请号：US17511485
申请日：2021-10-26
Applicant: OLYMPUS CORPORATION
Inventor： Yoshiharu SAITO , Kentaro IMOTO , Daisuke NISHIWAKI
Abstract: Provided is an optical signal detection device that includes: an objective; a holding member provided between the objective and a sample to hold the sample; and a gel member that fills a space between the objective and the holding member. The gel member has ¼ scale penetration indicating a value of 44 to 111, both inclusive, measured based on a penetration test using a ¼ scale cone of JIS K 2220.
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公开(公告)号：US20170010453A1
公开(公告)日：2017-01-12
申请号：US15275359
申请日：2016-09-24
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO , Shinichi TAKIMOTO , Shintaro TAKAHASHI , Atsushi DOI
CPC classification number: G02B21/0076 , G01N21/6458 , G01N2201/06113 , G01N2201/1053 , G01N2201/12 , G02B21/0032 , G02B21/006 , G02B21/0068 , G02B21/008 , G02B21/0084
Abstract: Provided is a microscope provided with: a scanner that scans an excitation beam coming from a light source; an objective optical system that focuses the scanned excitation beam onto a sample and that collects fluorescence generated at individual scanning positions in the sample; a detector that detects the collected fluorescence; a light blocking member that is disposed between the detector and the system and that partially blocks the collected fluorescence; a switching portion that switches the positional relationship between the member and a light-focusing point of the excitation beam in the sample between an optically conjugate positional relationship, in which an in-focus fluorescence generated at the light-focusing point passes through the member, and a non-conjugate positional relationship, in which the in-focus fluorescence is blocked by the member; and a computing portion that computes a difference between fluorescence signals acquired by the detector in the two positional relationships.
Abstract translation: 提供了一种显微镜，其具有：扫描来自光源的激发光束的扫描仪; 物镜光学系统，其将扫描的激发光束聚焦到样品上并且收集样品中各个扫描位置产生的荧光; 检测所收集的荧光的检测器; 光阻挡构件，其设置在所述检测器和所述系统之间并部分阻挡所述收集的荧光; 切换部，其以在所述光聚合点处产生的聚焦荧光透过所述构件的光学共轭位置关系之间切换所述构件与所述样品中的所述激发光束的聚光点之间的位置关系， 以及非共轭位置关系，其中聚焦荧光被构件阻挡; 以及计算部分，其计算由两个位置关系中的检测器获取的荧光信号之间的差异。
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公开(公告)号：US20200217716A1
公开(公告)日：2020-07-09
申请号：US16819406
申请日：2020-03-16
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO , Makoto ISHIKAKE
Abstract: An optical measurement device includes: an optical sensor that detects pulsed signal light and that outputs a detection signal formed of an exponential-function response; an A/D converter that samples the detection signal output from the optical sensor and that converts the detection signal into a digital signal; and a processor comprising hardware, the processor being configured to subject the digital signal output from the A/D converter to inverse transformation by using a multiple diagonal matrix, thus calculating an estimated pulse of the signal light.
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公开(公告)号：US20190004302A1
公开(公告)日：2019-01-03
申请号：US16102840
申请日：2018-08-14
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO , Ryusuke TANAKA , Hidenori TSUBOI
Abstract: Provided is an image-acquisition apparatus including: a scanning portion that scans illumination light emitted from a light source; an optical system that focuses the scanned illumination light on a sample, while collecting signal light beams generated at the individual scanning positions on the sample; a detector that detects the collected signal light beams and that generates detection signals thereof; a signal controller that is configured to generate periodic signals that are repeated at a predetermined period; a light controller that is configured to temporally control a position or an intensity of the illumination light in accordance with the generated periodic signals; and a computer that is configured to process, in accordance with the generated periodic signals, the detection signals generated, wherein the computer is provided with a frequency shifter for shifting frequencies of the detection signals, and an integrator that integrates the shifted detection signals at an integration time.
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公开(公告)号：US20210204817A1
公开(公告)日：2021-07-08
申请号：US17207019
申请日：2021-03-19
Applicant: OLYMPUS CORPORATION
Inventor： Yoshiaki MURAYAMA , Atsushi DOI , Kentaro IMOTO
IPC: A61B5/00
Abstract: A photoacoustic imaging device includes an excitation light irradiation unit that irradiates the same position of a specimen with two or more beams of pulsed excitation light separated by an irradiation time interval, a detector that detects an acoustic wave generated at the position irradiated with the excitation light by the excitation light irradiation unit, a generator that generates an image of the specimen based on the detected acoustic wave, and a controller that controls the irradiation time interval, the acoustic wave generated with a single beam of pulsed excitation light has multiple positive peaks that periodically occur, and the controller controls the irradiation time interval into a timing at which a second positive peak of the acoustic wave generated with the preceding excitation light is superimposed on a first positive peak of the acoustic wave generated with the subsequent excitation light.
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Patent Agency Ranking
公开(公告)号：US20190113459A1
公开(公告)日：2019-04-18
申请号：US16215809
申请日：2018-12-11
Applicant: OLYMPUS CORPORATION
Inventor： Asuka SUEKANE , Shintaro TAKAHASHI , Kentaro IMOTO , Atsushi DOI , Shinichi TAKIMOTO
IPC: G01N21/64
CPC classification number: G01N21/6458 , G01N21/6428 , G01N35/00 , G01N35/00722 , G01N2035/00891 , G01N2201/12
Abstract: An observation assistance device of the present invention includes: an information storage unit that stores sample state information showing a sample state change, a type of sample, a type of fluorescent substance, and an observation condition in fluorescence observation performed on a predetermined sample, and under a predetermined observation condition; an input unit via which inputs the type of sample to be observed and the type of fluorescent substance to be used; an assistance-display generating unit that reads sample state information and an observation condition of fluorescence observation performed on the same type of sample as the type of sample input, using the same type of fluorescent substance as the type of fluorescent substance, and generates an assistance display showing the sample state information in relation to the two or more parameters included in the observation condition; and a display unit that displays the generated assistance display.
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公开(公告)号：US20180195963A1
公开(公告)日：2018-07-12
申请号：US15909203
申请日：2018-03-01
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO
CPC classification number: G01N21/6458 , G01N21/6408 , G01N2021/6478 , G01N2201/06113 , G02B21/002 , G02B21/0032 , G02B21/0044 , G02B21/0076 , G02B21/0084 , G02B21/08 , G02B21/16
Abstract: Provided is a microscope including: a scanner for scanning excitation light; an objective optical system that focuses the excitation light onto a sample and that collects fluorescence generated by the sample; a light-blocking member for transmitting a portion of the collected fluorescence; a detector for detecting the fluorescence; a setting unit that allows types of fluorescence having passed through the light-blocking member to be detected by the detector at different times in two types of positional relationships in which the positional relationship between the position of an opening in the light-blocking member and a focal point of the objective optical system in the sample is set to an optically conjugate positional relationship, in which in-focus fluorescence passes through the light-blocking member, and to an optically nonconjugate positional relationship; and an arithmetic operation unit for calculating the difference between fluorescence signals acquired at different times by the detector.
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公开(公告)号：US20210208109A1
公开(公告)日：2021-07-08
申请号：US17207897
申请日：2021-03-22
Applicant: OLYMPUS CORPORATION
Inventor： Yoshiaki MURAYAMA , Atsushi DOI , Kentaro IMOTO
Abstract: A photoacoustic imaging device includes an irradiator irradiating a specimen with excitation light, a detection unit detecting an acoustic wave at an irradiated position, a propagation body including a bag-shaped body including a film deforming in conformity with a surface shape of the specimen, an interior of the bag-shaped body being filled with an acoustic wave propagation medium, and a processor including hardware and configured to generate an image based on the detected acoustic wave, wherein the propagation body is disposed between the detection unit and the specimen, without interposing any air layers, and moves along with relative movement of the detection unit and the specimen, the detection unit includes an optics collecting the acoustic wave, the propagation body is attached to the optics, and a difference of refractive indexes between the optics and the propagation body is smaller than a difference of refractive indexes between the optics and air.
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公开(公告)号：US20180073976A1
公开(公告)日：2018-03-15
申请号：US15813444
申请日：2017-11-15
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO
CPC classification number: G01N21/01 , G01N21/64 , G01N21/6458 , G01N2201/06113 , G01N2201/10 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/0084
Abstract: Provided is an image-obtaining device including: an illumination-light generating unit that modulates an intensity of light emitted from a light source, and generates illumination light beams having mutually linearly independent patterns and including modulated illumination light and unmodulated illumination light; an illumination optical system that irradiates different positions on a sample with the illumination light beams generated; a light-detecting unit that detects combined signal light resulting from combining signal light beams generated at irradiation positions irradiated with the illumination light beams, and outputs a combined signal; and a demodulation unit that separates, from the combined signal output, a modulated local signal by using a time integral of a product of a demodulation signal corresponding to the modulated illumination light beam and the combined signal, and separates an unmodulated local signal by subtracting a sum of the modulated local signals from a time integral of the combined signal.
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公开(公告)号：US20180059397A1
公开(公告)日：2018-03-01
申请号：US15683980
申请日：2017-08-23
Applicant: OLYMPUS CORPORATION
Inventor： Tatsuo NAKATA , Atsushi DOI , Kentaro IMOTO
CPC classification number: G02B21/0032 , G02B21/0044 , G02B21/0048 , G02B21/06 , G02B21/24
Abstract: Provided is a microscope system including: an objective lens that focuses, on a specimen, illumination light produced by a light source; an illumination-area switching mechanism that is disposed between the objective lens and the specimen and that switches an illumination area irradiated with the illumination light focused by the objective lens among a plurality of illumination areas on the specimen that are located outside the objective optical axis of the objective lens; and an inner focus lens that is disposed on the objective optical axis between the light source and the objective lens and that changes the focus position of the objective lens in the direction along the objective optical axis.
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