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公开(公告)号：US09815846B2
公开(公告)日：2017-11-14
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D403/12 , C07D401/12 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US20170114071A1
公开(公告)日：2017-04-27
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi- Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07D403/12 , C07D401/12 , C07C233/66 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06 , C07D213/75
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09896447B2
公开(公告)日：2018-02-20
申请号：US15023145
申请日：2014-09-17
申请人： MERCK SHARP & DOHME CORP. , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D239/42 , C07D213/16 , C07D261/14 , C07D231/40
CPC分类号： C07D471/04 , C07D213/16 , C07D231/40 , C07D239/42 , C07D261/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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公开(公告)号：US20160229804A1
公开(公告)日：2016-08-11
申请号：US15023634
申请日：2014-09-17
申请人： Andrew J. COOKE , Craig A. STUMP , Xu-Fang ZHANG , Chun Sing LI , Qinghua MAO , MERCK SHARP & DOHME CORP
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/12 , C07D239/42 , C07D498/04 , C07D231/40 , C07D261/14 , C07D471/04 , C07D233/88 , C07C275/28 , C07D257/04 , C07D249/08 , C07D295/135 , C07D401/04 , C07D487/04 , C07D271/10 , C07D285/12 , C07D405/04 , C07D263/32 , C07D403/04 , C07D277/48
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要翻译： 本发明涉及式（I）的苄基脲化合物，其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成 与神经生长因子（NGF）受体Trk-A，Trk-B和/或Trk-C的异常活动相关的疾病，失调，损伤或与异常髓鞘或脱髓鞘相关的疾病或障碍。
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公开(公告)号：US20220144771A1
公开(公告)日：2022-05-12
申请号：US17430409
申请日：2020-02-11
发明人： Stephane L. Bogen , Michael J. Breslin , Dane James Clausen , Anthony Ginnetti , Michael T. Rudd , Shawn J. Stachel , Craig A. Stump , Dexi Yang
IPC分类号： C07D207/14
摘要： The present invention is directed to pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20180105518A1
公开(公告)日：2018-04-19
申请号：US15562617
申请日：2016-04-04
发明人： Craig A. Stump , Yi Heng Chen , Ping Liu , Dongfang Meng , Jane Yang Wu , Chun Sing Li , Zhiqi Qi
IPC分类号： C07D471/04 , C07D417/12 , C07D487/04 , C07D403/12 , A61P25/00 , A61P35/00 , A61P9/10 , A61P17/06 , A61P7/02
CPC分类号： C07D471/04 , A61P7/02 , A61P9/10 , A61P17/06 , A61P25/00 , A61P35/00 , C07D403/12 , C07D417/12 , C07D473/04 , C07D487/04
摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09718782B2
公开(公告)日：2017-08-01
申请号：US15023634
申请日：2014-09-17
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/04 , C07D487/04 , C07D401/04 , C07D403/04 , C07D513/04 , C07D471/04 , C07D231/40 , C07D239/42 , C07D261/14 , C07D277/44 , C07D311/88 , C07D233/88 , C07D405/12 , C07D249/08 , C07C275/28 , C07D257/04 , C07D263/32 , C07D271/10 , C07D277/48 , C07D285/12 , C07D295/135 , C07D498/04
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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公开(公告)号：US11066396B2
公开(公告)日：2021-07-20
申请号：US16309390
申请日：2017-06-19
发明人： Abbas Walji , Richard Berger , Craig A. Stump , Kelly-Ann S. Schlegel , James J. Mulhearn , Thomas J. Greshock , Deping Wang , Mark E. Fraley , Kristen G. Jones
IPC分类号： C07D413/04 , C07D413/10 , C07D413/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/048 , C07D491/052 , C07D271/06 , C07D498/04 , C07D513/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P25/18 , A61P11/06 , A61P3/10 , A61K45/06 , A61P9/00 , C07F7/08 , A61P37/00 , C07D271/113 , A61P37/02 , C07D417/12
摘要： The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of aryl and heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.
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公开(公告)号：US10556900B2
公开(公告)日：2020-02-11
申请号：US15562617
申请日：2016-04-04
发明人： Craig A. Stump , Yi Heng Chen , Ping Liu , Dongfang Meng , Jane Yang Wu , Chun Sing Li , Zhiqi Qi
IPC分类号： C07D471/04 , C07D487/04 , C07D403/12 , C07D417/12 , A61P7/02 , A61P17/06 , A61P9/10 , A61P25/00 , A61P35/00
摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09914736B2
公开(公告)日：2018-03-13
申请号：US15128782
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Ping Liu , Dann Parker , Chun Sing Li , Qinghua Mao
IPC分类号： A61K31/40 , C07D487/04 , C07D277/46 , C07D231/40 , C07D417/12 , C07D401/04 , C07D417/14 , C07D403/14 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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