公开(公告)号：US20180105518A1

公开(公告)日：2018-04-19

申请号：US15562617

申请日：2016-04-04

申请人： Merck Sharp & Dohme Corp.

发明人： Craig A. Stump ,  Yi Heng Chen ,  Ping Liu ,  Dongfang Meng ,  Jane Yang Wu ,  Chun Sing Li ,  Zhiqi Qi

IPC分类号： C07D471/04 ,  C07D417/12 ,  C07D487/04 ,  C07D403/12 ,  A61P25/00 ,  A61P35/00 ,  A61P9/10 ,  A61P17/06 ,  A61P7/02

CPC分类号： C07D471/04 ,  A61P7/02 ,  A61P9/10 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  C07D403/12 ,  C07D417/12 ,  C07D473/04 ,  C07D487/04

摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

公开(公告)号：US10556900B2

公开(公告)日：2020-02-11

申请号：US15562617

申请日：2016-04-04

申请人： Merck Sharp & Dohme Corp.

发明人： Craig A. Stump ,  Yi Heng Chen ,  Ping Liu ,  Dongfang Meng ,  Jane Yang Wu ,  Chun Sing Li ,  Zhiqi Qi

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D403/12 ,  C07D417/12 ,  A61P7/02 ,  A61P17/06 ,  A61P9/10 ,  A61P25/00 ,  A61P35/00

摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.