公开(公告)号：US20180105518A1

公开(公告)日：2018-04-19

申请号：US15562617

申请日：2016-04-04

申请人： Merck Sharp & Dohme Corp.

发明人： Craig A. Stump ,  Yi Heng Chen ,  Ping Liu ,  Dongfang Meng ,  Jane Yang Wu ,  Chun Sing Li ,  Zhiqi Qi

IPC分类号： C07D471/04 ,  C07D417/12 ,  C07D487/04 ,  C07D403/12 ,  A61P25/00 ,  A61P35/00 ,  A61P9/10 ,  A61P17/06 ,  A61P7/02

CPC分类号： C07D471/04 ,  A61P7/02 ,  A61P9/10 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  C07D403/12 ,  C07D417/12 ,  C07D473/04 ,  C07D487/04

摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

公开(公告)号：US10556900B2

公开(公告)日：2020-02-11

申请号：US15562617

申请日：2016-04-04

申请人： Merck Sharp & Dohme Corp.

发明人： Craig A. Stump ,  Yi Heng Chen ,  Ping Liu ,  Dongfang Meng ,  Jane Yang Wu ,  Chun Sing Li ,  Zhiqi Qi

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D403/12 ,  C07D417/12 ,  A61P7/02 ,  A61P17/06 ,  A61P9/10 ,  A61P25/00 ,  A61P35/00

摘要： The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

公开(公告)号：US10351558B2

公开(公告)日：2019-07-16

申请号：US15550862

申请日：2016-02-12

申请人： Merck Sharp & Dohme Corp. ,  Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

发明人： Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

IPC分类号： C07D471/04 ,  C07D403/12 ,  C07D417/14 ,  A61P9/00 ,  C07D413/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：US20180022747A1

公开(公告)日：2018-01-25

申请号：US15550862

申请日：2016-02-12

申请人： Dongfang MENG ,  Hong LI ,  Meng YANG ,  Manuel de Lera RUIZ ,  Sunita V. DEWNANI ,  Tianying JIAN ,  Dann L. PARKER, JR. ,  Ting ZHANG ,  Louis-Charles CAMPEAU ,  Bart HARPER ,  Harold B. WOOD ,  Jiayi XU ,  Richard BERGER ,  Jane Yang WU ,  Robert K. ORR ,  Shawn P. WALSH ,  Merck Sharp & Dohme Corp.

发明人： Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

IPC分类号： C07D471/04 ,  C07D403/12 ,  C07D498/04 ,  C07D417/14 ,  C07D513/04 ,  C07D471/14 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61P9/00 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.