-
公开(公告)号：US09815846B2
公开(公告)日：2017-11-14
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D403/12 , C07D401/12 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
公开(公告)号：US09896447B2
公开(公告)日：2018-02-20
申请号：US15023145
申请日：2014-09-17
申请人： MERCK SHARP & DOHME CORP. , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D239/42 , C07D213/16 , C07D261/14 , C07D231/40
CPC分类号： C07D471/04 , C07D213/16 , C07D231/40 , C07D239/42 , C07D261/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
-
公开(公告)号：US20160229804A1
公开(公告)日：2016-08-11
申请号：US15023634
申请日：2014-09-17
申请人： Andrew J. COOKE , Craig A. STUMP , Xu-Fang ZHANG , Chun Sing LI , Qinghua MAO , MERCK SHARP & DOHME CORP
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/12 , C07D239/42 , C07D498/04 , C07D231/40 , C07D261/14 , C07D471/04 , C07D233/88 , C07C275/28 , C07D257/04 , C07D249/08 , C07D295/135 , C07D401/04 , C07D487/04 , C07D271/10 , C07D285/12 , C07D405/04 , C07D263/32 , C07D403/04 , C07D277/48
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要翻译： 本发明涉及式（I）的苄基脲化合物，其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成 与神经生长因子（NGF）受体Trk-A，Trk-B和/或Trk-C的异常活动相关的疾病，失调，损伤或与异常髓鞘或脱髓鞘相关的疾病或障碍。
-
公开(公告)号：US09718782B2
公开(公告)日：2017-08-01
申请号：US15023634
申请日：2014-09-17
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/04 , C07D487/04 , C07D401/04 , C07D403/04 , C07D513/04 , C07D471/04 , C07D231/40 , C07D239/42 , C07D261/14 , C07D277/44 , C07D311/88 , C07D233/88 , C07D405/12 , C07D249/08 , C07C275/28 , C07D257/04 , C07D263/32 , C07D271/10 , C07D277/48 , C07D285/12 , C07D295/135 , C07D498/04
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
-
公开(公告)号：US09914736B2
公开(公告)日：2018-03-13
申请号：US15128782
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Ping Liu , Dann Parker , Chun Sing Li , Qinghua Mao
IPC分类号： A61K31/40 , C07D487/04 , C07D277/46 , C07D231/40 , C07D417/12 , C07D401/04 , C07D417/14 , C07D403/14 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
公开(公告)号：US20150336948A1
公开(公告)日：2015-11-26
申请号：US14404208
申请日：2013-05-24
发明人： Michael D. Altman , Christian Fischer , Jason D. Katz , Theresa M. Williams , Xu-Fang Zhang , Hua Zhou
IPC分类号： C07D471/04 , C07D231/12
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05 , C07D231/12 , C07D471/08
摘要： The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.
摘要翻译： 本发明涉及对神经原纤维缠结（NFT）具有高亲和力的同位素标记的联芳基脲化合物，因此可用于确定脑中NFT的量和分布。 同位素标记的联芳基脲化合物也可用作PET示踪剂，并用于竞争测定以鉴定可用作PET示踪剂的其它化合物。
-
公开(公告)号：US09862716B2
公开(公告)日：2018-01-09
申请号：US15129206
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Keith P. Moore , Ping Liu , Harold B. Wood , Chun Sing Li , Qinghua Mao , Douglas C. Beshore
IPC分类号： C07D471/04 , C07D513/04
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
公开(公告)号：US20170158698A1
公开(公告)日：2017-06-08
申请号：US15128782
申请日：2015-03-23
申请人： Helen MITCHELL , Mark E. FRALEY , Andrew J. COOKE , Craig A. STUMP , Xu-Fang ZHANG , Casey C. MCCOMAS , Kathy SCHIRRIPA , Melody MCWHERTER , Ping LIU , Dann PARKER , Chun Sing LI , Qinghua MAO , Merck Sharp & Dohme Corp.
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Ping Liu , Dann Parker , Chun Sing Li , Qinghua Mao
IPC分类号： C07D487/04 , C07D231/40 , C07D417/12 , C07D401/04 , C07D417/14 , C07D471/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D277/46 , C07D403/14
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
公开(公告)号：US20170114071A1
公开(公告)日：2017-04-27
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi- Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07D403/12 , C07D401/12 , C07C233/66 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06 , C07D213/75
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
公开(公告)号：US20170114056A1
公开(公告)日：2017-04-27
申请号：US15129206
申请日：2015-03-23
申请人： Helen MITCHELL , Mark E. FRALEY , Andrew J. COOKE , Craig A. STUMP , Yi Heng CHEN , Douglas C. BESHORE , Xu-Fank ZHANG , Casey C. MCCOMAS , Kathy SCHIRRIPA , Melody MCWHERTER , Swati P. MERCER , Keith P. MOORE , Ping LIU , Harold B. WOOD , Chun Sing LI , Qinghua MAO , Merck Sharp & Dohme Corp.
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi- Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Keith P. Moore , Ping Liu , Harold B. Wood , Chun Sing Li , Qinghua Mao , Douglas C. Beshore
IPC分类号： C07D471/04 , C07D513/04
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.036 秒)
