发明申请
- 专利标题： Isotopically Labeled Biaryl Urea Compounds
- 专利标题（中）： 同位素标记的二芳基脲化合物
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申请号： US14404208申请日： 2013-05-24
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公开(公告)号： US20150336948A1公开(公告)日： 2015-11-26
- 发明人: Michael D. Altman , Christian Fischer , Jason D. Katz , Theresa M. Williams , Xu-Fang Zhang , Hua Zhou
- 申请人： Merck Sharp & Dohme Corp.
- 国际申请： PCT/US13/42554 WO 20130524
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D231/12
摘要：
The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.
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