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公开(公告)号：US09718782B2
公开(公告)日：2017-08-01
申请号：US15023634
申请日：2014-09-17
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/04 , C07D487/04 , C07D401/04 , C07D403/04 , C07D513/04 , C07D471/04 , C07D231/40 , C07D239/42 , C07D261/14 , C07D277/44 , C07D311/88 , C07D233/88 , C07D405/12 , C07D249/08 , C07C275/28 , C07D257/04 , C07D263/32 , C07D271/10 , C07D277/48 , C07D285/12 , C07D295/135 , C07D498/04
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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公开(公告)号：US09815846B2
公开(公告)日：2017-11-14
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D403/12 , C07D401/12 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09914736B2
公开(公告)日：2018-03-13
申请号：US15128782
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Ping Liu , Dann Parker , Chun Sing Li , Qinghua Mao
IPC分类号： A61K31/40 , C07D487/04 , C07D277/46 , C07D231/40 , C07D417/12 , C07D401/04 , C07D417/14 , C07D403/14 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09896447B2
公开(公告)日：2018-02-20
申请号：US15023145
申请日：2014-09-17
申请人： MERCK SHARP & DOHME CORP. , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D239/42 , C07D213/16 , C07D261/14 , C07D231/40
CPC分类号： C07D471/04 , C07D213/16 , C07D231/40 , C07D239/42 , C07D261/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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公开(公告)号：US20160229804A1
公开(公告)日：2016-08-11
申请号：US15023634
申请日：2014-09-17
申请人： Andrew J. COOKE , Craig A. STUMP , Xu-Fang ZHANG , Chun Sing LI , Qinghua MAO , MERCK SHARP & DOHME CORP
发明人： Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
IPC分类号： C07D213/75 , C07D405/12 , C07D239/42 , C07D498/04 , C07D231/40 , C07D261/14 , C07D471/04 , C07D233/88 , C07C275/28 , C07D257/04 , C07D249/08 , C07D295/135 , C07D401/04 , C07D487/04 , C07D271/10 , C07D285/12 , C07D405/04 , C07D263/32 , C07D403/04 , C07D277/48
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要翻译： 本发明涉及式（I）的苄基脲化合物，其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成 与神经生长因子（NGF）受体Trk-A，Trk-B和/或Trk-C的异常活动相关的疾病，失调，损伤或与异常髓鞘或脱髓鞘相关的疾病或障碍。
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公开(公告)号：US09862716B2
公开(公告)日：2018-01-09
申请号：US15129206
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Keith P. Moore , Ping Liu , Harold B. Wood , Chun Sing Li , Qinghua Mao , Douglas C. Beshore
IPC分类号： C07D471/04 , C07D513/04
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US09862707B2
公开(公告)日：2018-01-09
申请号：US15128793
申请日：2015-03-23
发明人： Helen Mitchell , Harold B. Wood , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D403/12 , C07D471/04 , C07D403/14 , C07D487/04 , C07D401/12
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US20170158698A1
公开(公告)日：2017-06-08
申请号：US15128782
申请日：2015-03-23
申请人： Helen MITCHELL , Mark E. FRALEY , Andrew J. COOKE , Craig A. STUMP , Xu-Fang ZHANG , Casey C. MCCOMAS , Kathy SCHIRRIPA , Melody MCWHERTER , Ping LIU , Dann PARKER , Chun Sing LI , Qinghua MAO , Merck Sharp & Dohme Corp.
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Ping Liu , Dann Parker , Chun Sing Li , Qinghua Mao
IPC分类号： C07D487/04 , C07D231/40 , C07D417/12 , C07D401/04 , C07D417/14 , C07D471/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D277/46 , C07D403/14
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US20170114071A1
公开(公告)日：2017-04-27
申请号：US15128689
申请日：2015-03-23
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi- Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
IPC分类号： C07D491/107 , C07D403/12 , C07D401/12 , C07C233/66 , C07D417/12 , C07D239/42 , C07D401/04 , C07D413/12 , C07D417/14 , C07D401/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D401/06 , C07D413/06 , C07D403/06 , C07D213/75
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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公开(公告)号：US20170114056A1
公开(公告)日：2017-04-27
申请号：US15129206
申请日：2015-03-23
申请人： Helen MITCHELL , Mark E. FRALEY , Andrew J. COOKE , Craig A. STUMP , Yi Heng CHEN , Douglas C. BESHORE , Xu-Fank ZHANG , Casey C. MCCOMAS , Kathy SCHIRRIPA , Melody MCWHERTER , Swati P. MERCER , Keith P. MOORE , Ping LIU , Harold B. WOOD , Chun Sing LI , Qinghua MAO , Merck Sharp & Dohme Corp.
发明人： Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi- Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Keith P. Moore , Ping Liu , Harold B. Wood , Chun Sing Li , Qinghua Mao , Douglas C. Beshore
IPC分类号： C07D471/04 , C07D513/04
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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