Invention Grant
- Patent Title: TrkA kinase inhibitors, compositions and methods thereof
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Application No.: US15023145Application Date: 2014-09-17
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Publication No.: US09896447B2Publication Date: 2018-02-20
- Inventor: Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
- Applicant: MERCK SHARP & DOHME CORP. , Andrew J. Cooke , Craig A. Stump , Xu-Fang Zhang , Chun Sing Li , Qinghua Mao
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- Priority: WOPCT/CN2013/083931 20130922
- International Application: PCT/US2014/055976 WO 20140917
- International Announcement: WO2015/042085 WO 20150326
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D239/42 ; C07D213/16 ; C07D261/14 ; C07D231/40
Abstract:
The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
Public/Granted literature
- US20160229850A1 TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF Public/Granted day:2016-08-11
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