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公开(公告)号：US20120214867A1
公开(公告)日：2012-08-23
申请号：US13396110
申请日：2012-02-14
CPC分类号： C12N5/0006 , B82Y5/00 , C12N2795/10023
摘要： A T4 nanoparticle is a non-infectious, tail-less variant of a T4 bacteriophage. In one embodiment, eukaryotic cells are labeled with dyed T4 nanoparticles, wherein each dyed T4 nanoparticle comprises at least 350 dye molecules covalently bound thereto. In another embodiment, T4 nanoparticles are used to deliver exogenous DNA to eukaryotic cells for protein expression therein. It is contemplated that T4 nanoparticles may be used to deliver other exogenous material to eukaryotic cells.
摘要翻译： T4纳米颗粒是T4噬菌体的无感染，无尾的变体。 在一个实施方案中，用染色的T4纳米颗粒标记真核细胞，其中每个染色的T4纳米颗粒包含至少350个与其共价结合的染料分子。 在另一个实施方案中，使用T4纳米颗粒将外源DNA递送到真核细胞中用于蛋白质表达。 预期T4纳米颗粒可用于将其它外源材料递送至真核细胞。
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公开(公告)号：US20130181171A1
公开(公告)日：2013-07-18
申请号：US13349189
申请日：2012-01-12
申请人： Banahalli R. Ratna , Amy S. Blum , Carissa M. Soto , Michael A. Bruckman , Jinny Lin Liu , Ronald W. Rendell , James Peter Long , Ronald J. Tonucci
发明人： Banahalli R. Ratna , Amy S. Blum , Carissa M. Soto , Michael A. Bruckman , Jinny Lin Liu , Ronald W. Rendell , James Peter Long , Ronald J. Tonucci
CPC分类号： B82Y20/00 , B82Y40/00 , G01N21/554
摘要： Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.
摘要翻译： 经修饰以掺入多组氨酸的烟草花叶病毒外壳蛋白的蛋白质支架可以与金属或染料结合，同时具有改进的自组装特性。 支架可以采取管或盘的形式，并且可以进一步形成双等离子体环谐振器。 这种自组装结构提供有用的光学性质。
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公开(公告)号：US08831386B2
公开(公告)日：2014-09-09
申请号：US13349189
申请日：2012-01-12
申请人： Banahalli R. Ratna , Amy S. Blum , Carissa M. Soto , Michael A. Bruckman , Jinny Lin Liu , Ronald W. Rendell , James Peter Long , Ronald J. Tonucci
发明人： Banahalli R. Ratna , Amy S. Blum , Carissa M. Soto , Michael A. Bruckman , Jinny Lin Liu , Ronald W. Rendell , James Peter Long , Ronald J. Tonucci
CPC分类号： B82Y20/00 , B82Y40/00 , G01N21/554
摘要： Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.
摘要翻译： 经修饰以掺入多组氨酸的烟草花叶病毒外壳蛋白的蛋白质支架可以与金属或染料结合，同时具有改进的自组装特性。 支架可以采取管或盘的形式，并且可以进一步形成双等离子体环谐振器。 这种自组装结构提供有用的光学性质。
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4.发明申请公开(公告)号：US20150268214A1
公开(公告)日：2015-09-24
申请号：US13653474
申请日：2012-10-17
CPC分类号： G01N33/227 , C07K16/44 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , G01N33/5308
摘要： Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
摘要翻译： 本文描述了有效结合三硝基甲苯（TNT）的新的识别元件（抗体或其功能片段）。 还公开了单链片段识别元件。
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5.发明申请Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood 审中-公开使用宿主基因表达生物标志物在血液中的传染病临床表型和其他生理状态的诊断和预后公开(公告)号：US20110183856A1
公开(公告)日：2011-07-28
申请号：US12713554
申请日：2010-02-26
申请人： Brian K. Agan , Eric H. Hanson , Michael J. Jenkins , Baochuan Lin , Chris C. Olsen , Robb K. Rowley , David A. Stenger , Dzung C. Thach , Clark J. Tibbetts , Elizabeth A. Walter , Jinny Lin Liu
发明人： Brian K. Agan , Eric H. Hanson , Michael J. Jenkins , Baochuan Lin , Chris C. Olsen , Robb K. Rowley , David A. Stenger , Dzung C. Thach , Clark J. Tibbetts , Elizabeth A. Walter , Jinny Lin Liu
IPC分类号： C40B30/00
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/158
摘要： The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.
摘要翻译： 本发明提供来自外周血白细胞的特异性基因表达标志物，其指示宿主对暴露，应答和恢复感染性病原体感染的反应。 本发明还提供了用于鉴定特定基因表达标志物组的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发病的方法，诊断感染性病原体感染的方法以及鉴定 涉及病原体。
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6.发明授权Passaged neural stem cell-derived neuronal networks as sensing elements for detection of environmental threats 失效传代神经干细胞衍生的神经元网络作为检测环境威胁的感知元件公开(公告)号：US07947626B2
公开(公告)日：2011-05-24
申请号：US11846810
申请日：2007-08-29
申请人： Wu Ma , Jinny Lin Liu , Thomas O'Shaughnessy
发明人： Wu Ma , Jinny Lin Liu , Thomas O'Shaughnessy
CPC分类号： C40B50/06 , C12N5/0623 , C12N2501/115 , C12N2501/13 , C12N2531/00 , C12N2533/32 , C12N2533/52 , G01N33/5058 , G06N3/061
摘要： This invention comprises a method for generating functional neural networks using neural progenitor cells on microelectrode arrays (MEAs). The method involves dissociating neural progenitor cells from an embryo, propagating the neural progenitor cells, passaging the neural progenitor cells and seeding the neural progenitor cells on MEAs to produce a functional neural network. The neural progenitor cells may be continuously passaged to propagate an endless supply of neural progenitor cells. The resultant passaged progenitor cell derived neural network MEA may be used to detect and/or quantify various biological or chemical toxins.
摘要翻译： 本发明包括使用微电极阵列（MEA）上的神经祖细胞产生功能性神经网络的方法。 该方法包括从胚胎中分离神经祖细胞，传播神经祖细胞，传代神经祖细胞并将神经祖细胞接种在MEA上以产生功能性神经网络。 可以连续传代神经祖细胞以传播无限供应的神经祖细胞。 所得到的传代祖细胞衍生的神经网络MEA可用于检测和/或定量各种生物或化学毒素。
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公开(公告)号：US09778265B2
公开(公告)日：2017-10-03
申请号：US14688010
申请日：2015-04-16
IPC分类号： G01N33/68 , C07K14/00 , C12N15/62 , G01N33/531 , G01N33/543 , C07K19/00 , C07K16/16
CPC分类号： G01N33/68 , C07K14/00 , C07K16/16 , C07K19/00 , C07K2317/569 , C07K2319/73 , C12N15/62 , G01N33/531 , G01N33/54393 , G01N2333/42
摘要： Genetic fusions of proteins, for example single-domain antibodies (sdAbs), with a positively-charged domain enhanced immobilization of active protein in a desired orientation.
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8.发明申请Charged Peptide Appendage to Facilitate Oriented Protein Covalent Immobilization 有权带电肽附件促进定向蛋白质共价固定公开(公告)号：US20160305948A1
公开(公告)日：2016-10-20
申请号：US14688010
申请日：2015-04-16
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , C07K14/00 , C07K16/16 , C07K19/00 , C07K2317/569 , C07K2319/73 , C12N15/62 , G01N33/531 , G01N33/54393 , G01N2333/42
摘要： Genetic fusions of proteins, for example single-domain antibodies (sdAbs), with a positively-charged domain enhanced immobilization of active protein in a desired orientation.
摘要翻译： 具有带正电荷结构域的蛋白质的遗传融合，例如单结构域抗体（sdAb）增强了活性蛋白在期望取向上的固定化。
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9.发明授权公开(公告)号：US09267930B2
公开(公告)日：2016-02-23
申请号：US13653474
申请日：2012-10-17
CPC分类号： G01N33/227 , C07K16/44 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , G01N33/5308
摘要： Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
摘要翻译： 本文描述了有效结合三硝基甲苯（TNT）的新的识别元件（抗体或其功能片段）。 还公开了单链片段识别元件。
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