专利检索 ap:("Fuad Mehraban" OR "Mary Gerritsen" OR "Luca Rastelli") AND inv:"Mary Gerritsen" 第 1 页

1.

发明申请
DIFFERENTIALLY EXPRESSED GENES INVOLVED IN ANGIOGENESIS, THE POLYPEPTIDES ENCODED THEREBY, AND METHODS OF USING THE SAME 审中-公开
标题翻译：与生物降解有关的差异表达基因，编码的多肽及其使用方法

公开(公告)号：US20080241835A1

公开(公告)日：2008-10-02

申请号：US11927609

申请日：2007-10-29

申请人： Fuad Mehraban , Mary Gerritsen , Luca Rastelli

发明人： Fuad Mehraban , Mary Gerritsen , Luca Rastelli

IPC分类号： C12Q1/68 , C12Q1/00

CPC分类号： C07K14/47 , A61K48/00 , C12N2799/026 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158

摘要： The present invention is directed to nucleic acid sequences and the polypeptides encoded thereby that are differentially expressed in angiogenesis. Also provided are methods for stimulating or inhibiting angiogenesis in mammals, including humans. Pharmaceutical compositions based on polypeptides, agonists, or antagonists thereto are also provided. Additionally, the invention also provides methods for diagnosing and treating angiogenic disorders including, but not limited to, wound healing and cancer.

摘要翻译： 本发明涉及在血管发生中差异表达的核酸序列和由其编码的多肽。还提供了用于刺激或抑制哺乳动物（包括人）中血管生成的方法。还提供了基于多肽，激动剂或其拮抗剂的药物组合物。另外，本发明还提供诊断和治疗血管生成障碍的方法，包括但不限于伤口愈合和癌症。

2.

发明申请
Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization 审中-公开
标题翻译：新型多肽，其核酸，及其用于血管生成和血管形成的方法

公开(公告)号：US20050032693A1

公开(公告)日：2005-02-10

申请号：US10811080

申请日：2004-03-26

申请人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban

发明人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban

IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P17/00 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12R1/93 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , A61K38/17 , C07H21/04

CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/027

摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.

摘要翻译： 本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。

3.

发明申请
Novel sphingosine kinases 审中-公开
标题翻译：新型鞘氨醇激酶

公开(公告)号：US20050123942A1

公开(公告)日：2005-06-09

申请号：US10876281

申请日：2004-06-24

申请人： Mary Gerritsen , Luca Rastelli

发明人： Mary Gerritsen , Luca Rastelli

IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , C07H21/04 , C12Q1/68

CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , A61K48/00

摘要： Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码多肽的新型人核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

4.

发明申请
Angiogenesis associated proteins, and nucleic acids encoding the same 审中-公开
标题翻译：血管发生相关蛋白和编码相同的核酸

公开(公告)号：US20060074023A1

公开(公告)日：2006-04-06

申请号：US11285818

申请日：2005-11-22

申请人： Mary Gerritsen , Luca Rastelli

发明人： Mary Gerritsen , Luca Rastelli

IPC分类号： A61K38/17 , C07K14/82 , C07K16/30 , C07H21/04 , C12P21/06

CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075

摘要： An isolated polypeptide having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.

摘要翻译： 与序列SEQ ID NO：2,4,6,8,10,12或16具有至少80％序列同一性的分离多肽和编码该多肽的多核苷酸可用于调节血管发生。

5.

发明申请
ErbB4 antagonists 审中-公开
标题翻译： ErbB4拮抗剂

公开(公告)号：US20070092513A1

公开(公告)日：2007-04-26

申请号：US11581221

申请日：2006-10-13

申请人： Mary Gerritsen , Mark Sliwkowski

发明人： Mary Gerritsen , Mark Sliwkowski

IPC分类号： A61K39/395

CPC分类号： C07K14/82 , A61K38/00 , C07K14/4756 , C07K16/32 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , G01N33/5061

摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

摘要翻译： 本发明涉及通过使用天然ErbB4受体的拮抗剂来控制平滑肌细胞的过度增殖和/或迁移，特别是用于治疗狭窄的方法和手段。本发明还涉及鉴定能够抑制或增强平滑肌细胞增殖或迁移的ErbB4激动剂和拮抗剂的方法。

6.

发明申请
Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开

公开(公告)号：US20060074221A1

公开(公告)日：2006-04-06

申请号：US10219064

申请日：2002-08-13

申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood

发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood

IPC分类号： C07K14/47 , C07H21/04 , C12P21/06 , C12N9/00 , C07K16/18

CPC分类号： C07K14/705 , C07K14/47 , G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

7.

发明申请
Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开

公开(公告)号：US20060040351A1

公开(公告)日：2006-02-23

申请号：US10973115

申请日：2004-10-22

申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang

发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang

IPC分类号： C07H21/04 , C12P21/06 , C12N9/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

8.

发明申请
Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开

公开(公告)号：US20050227328A1

公开(公告)日：2005-10-13

申请号：US11129762

申请日：2005-05-13

申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood

发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood

IPC分类号： A61K38/00 , A61K39/395 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C07H21/04 , C07K16/18 , C12N9/00 , C12N15/09

CPC分类号： C07K14/47 , A61K38/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

9.

发明申请
Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs 审中-公开
标题翻译：通过肿瘤坏死因子配体/受体同系物促进或抑制血管生成和心血管化

公开(公告)号：US20050202008A1

公开(公告)日：2005-09-15

申请号：US11032294

申请日：2005-01-10

申请人： P. Mickey Williams , Mary Gerritsen

发明人： P. Mickey Williams , Mary Gerritsen

IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07K14/47 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574

CPC分类号： G01N33/566 , A61K38/177 , C07K14/47 , C07K2319/30 , C12N2799/026 , G01N2333/525 , G01N2333/70575 , G01N2333/70578

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.

摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。