公开(公告)号：US20080241835A1

公开(公告)日：2008-10-02

申请号：US11927609

申请日：2007-10-29

申请人： Fuad Mehraban ,  Mary Gerritsen ,  Luca Rastelli

发明人： Fuad Mehraban ,  Mary Gerritsen ,  Luca Rastelli

IPC分类号： C12Q1/68 ,  C12Q1/00

CPC分类号： C07K14/47 ,  A61K48/00 ,  C12N2799/026 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention is directed to nucleic acid sequences and the polypeptides encoded thereby that are differentially expressed in angiogenesis. Also provided are methods for stimulating or inhibiting angiogenesis in mammals, including humans. Pharmaceutical compositions based on polypeptides, agonists, or antagonists thereto are also provided. Additionally, the invention also provides methods for diagnosing and treating angiogenic disorders including, but not limited to, wound healing and cancer.

摘要翻译： 本发明涉及在血管发生中差异表达的核酸序列和由其编码的多肽。 还提供了用于刺激或抑制哺乳动物（包括人）中血管生成的方法。 还提供了基于多肽，激动剂或其拮抗剂的药物组合物。 另外，本发明还提供诊断和治疗血管生成障碍的方法，包括但不限于伤口愈合和癌症。

公开(公告)号：US20050032693A1

公开(公告)日：2005-02-10

申请号：US10811080

申请日：2004-03-26

申请人： Mary Gerritsen ,  Audrey Goddard ,  J. Grimaldi ,  Fuad Mehraban

发明人： Mary Gerritsen ,  Audrey Goddard ,  J. Grimaldi ,  Fuad Mehraban

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P7/00 ,  A61P9/10 ,  A61P17/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/46 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  C12R1/93 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00 ,  A61K38/17 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/027

摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.

摘要翻译： 本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。