公开(公告)号：US08846873B2

公开(公告)日：2014-09-30

申请号：US13355366

申请日：2012-01-20

申请人： Feng Xiao ,  Xiao-Chi Jia ,  Meina Liang ,  Orit Foord ,  Scott Klakamp ,  Kam Fai Tse ,  Vincent A. Pollack ,  Luca Rastelli ,  John Herrmann ,  Henri Lichenstein ,  Michael Jeffers ,  William LaRochelle ,  Gulshan Ara ,  Peter Mezes ,  Andrei Chapoval ,  Cyrus Karkaria ,  Michael Torgov ,  Juan Davagnino

发明人： Feng Xiao ,  Xiao-Chi Jia ,  Meina Liang ,  Orit Foord ,  Scott Klakamp ,  Kam Fai Tse ,  Vincent A. Pollack ,  Luca Rastelli ,  John Herrmann ,  Henri Lichenstein ,  Michael Jeffers ,  William LaRochelle ,  Gulshan Ara ,  Peter Mezes ,  Andrei Chapoval ,  Cyrus Karkaria ,  Michael Torgov ,  Juan Davagnino

IPC分类号： C07K16/30 ,  C07K19/00 ,  C07K16/28 ,  A61K47/48 ,  A61K39/00

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.

摘要翻译： 本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。 提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。 本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。 本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

公开(公告)号：US20130022597A1

公开(公告)日：2013-01-24

申请号：US13355366

申请日：2012-01-20

申请人： Meina Liang ,  Orit Foord ,  Scott Klakamp ,  Vincent A. Pollack ,  Luca Rastelli ,  John Herrmann ,  Henri Lichenstein ,  Michael Jeffers ,  William LaRochelle ,  Peter Mezes ,  Andrei Chapoval ,  Cyrus Karkaria ,  Michael Torgov ,  Juan Davagnino

发明人： Feng Xiao ,  Xiao-Chi Jia ,  Meina Liang ,  Orit Foord ,  Scott Klakamp ,  Kam Fai Tse ,  Vincent A. Pollack ,  Luca Rastelli ,  John Herrmann ,  Henri Lichenstein ,  Michael Jeffers ,  William LaRochelle ,  Gulshan Ara ,  Peter Mezes ,  Andrei Chapoval ,  Cyrus Karkaria ,  Michael Torgov ,  Juan Davagnino

IPC分类号： A61K39/395 ,  C12N15/13 ,  C40B30/04 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10 ,  C07K16/18 ,  A61P35/00

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.

摘要翻译： 本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。 提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。 本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。 本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

公开(公告)号：US07566536B2

公开(公告)日：2009-07-28

申请号：US10614599

申请日：2003-07-07

申请人： David P. Andrew ,  David A. Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Tallion

发明人： David P. Andrew ,  David A. Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Tallion

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C07K14/52 ,  A61K38/00

摘要： The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

摘要翻译： 本发明提供了称为FCTRX多肽的新型多肽，以及编码FCTRX多肽的多核苷酸和免疫特异性结合FCTRX或FCTRX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明还提供了FCTRX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20060172941A1

公开(公告)日：2006-08-03

申请号：US11327849

申请日：2006-01-09

申请人： Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

发明人： Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

IPC分类号： A61K39/00 ,  C07K14/475

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K47/62 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

摘要翻译： 公开了抑制内皮细胞活化或增殖的抗血管生成肽。 这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）和bFGF与其受体的结合。 这些肽也可用于抑制血管生成相关疾病如癌症，白血病，多发性骨髓瘤，炎性疾病，眼睛疾病和皮肤疾病中的VEGF，bFGF或整合素激活内皮细胞。

公开(公告)号：US07034132B2

公开(公告)日：2006-04-25

申请号：US10162335

申请日：2002-06-03

申请人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

发明人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060013813A1

公开(公告)日：2006-01-19

申请号：US11054281

申请日：2005-02-08

申请人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

发明人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  A61K39/395 ,  C07K14/705 ,  C07K16/18

CPC分类号： C12N9/2462 ,  A61K38/00 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6869 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  G01N33/6893

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050123942A1

公开(公告)日：2005-06-09

申请号：US10876281

申请日：2004-06-24

申请人： Mary Gerritsen ,  Luca Rastelli

发明人： Mary Gerritsen ,  Luca Rastelli

IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/12 ,  C12N15/54 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

摘要： Disclosed herein are novel human nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US09051615B2

公开(公告)日：2015-06-09

申请号：US13462300

申请日：2012-05-02

申请人： Luca Rastelli ,  Bonnie Gould-Rothberg ,  Ryan Murphey

发明人： Luca Rastelli ,  Bonnie Gould-Rothberg ,  Ryan Murphey

IPC分类号： C07K16/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/574 ,  G01N2500/10

摘要： Disclosed are methods of detecting and treating tuberous sclerosis complex associated disorders. Also disclosed are methods of identifying agents for treating tuberous sclerosis complex associated disorders.

摘要翻译： 公开了检测和治疗结节性硬化综合征相关疾病的方法。 还公开了鉴定用于治疗结节性硬化综合征相关病症的药剂的方法。

公开(公告)号：US20090047335A1

公开(公告)日：2009-02-19

申请号：US11659731

申请日：2005-08-05

申请人： Luca Rastelli ,  Mary Kay Lescoe ,  Melissa Corso ,  Richard Kitson ,  Judith Landin ,  Lina Souan ,  Uriel M. Malyankar

发明人： Luca Rastelli ,  Mary Kay Lescoe ,  Melissa Corso ,  Richard Kitson ,  Judith Landin ,  Lina Souan ,  Uriel M. Malyankar

IPC分类号： A61K9/127 ,  C07K7/00 ,  A61K9/14 ,  C12N1/20 ,  A61P31/00 ,  C40B50/00 ,  C12N5/06 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08

摘要： Anti-angiogenic peptides that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR). Such peptides may also be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases and skin disorders.

摘要翻译： 公开了抑制VEGF介导的内皮细胞活化或增殖的抗血管生成肽。 这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）。 这样的肽也可以用于抑制VEGF介导的血管生成相关疾病如癌症，炎症性疾病，眼睛疾病和皮肤病中内皮细胞的活化。