公开(公告)号：US20080207502A1

公开(公告)日：2008-08-28

申请号：US11665176

申请日：2005-10-14

Applicant: Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

Inventor： Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

IPC: A61K38/17 ,  C07K14/435 ,  C07K7/08 ,  A61K38/03 ,  A61P35/04 ,  A61P27/02 ,  C12N5/02 ,  A61K38/10 ,  C07K4/12

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K47/62 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

Abstract: Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides maybe used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

Abstract translation: 公开了抑制内皮细胞活化或增殖的抗血管生成肽。 这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）和bFGF与其受体的结合。 这些肽也可用于抑制血管生成相关疾病如癌症，白血病，多发性骨髓瘤，炎性疾病，眼睛疾病和皮肤疾病中的VEGF，bFGF或整合素激活内皮细胞。

公开(公告)号：US20090047335A1

公开(公告)日：2009-02-19

申请号：US11659731

申请日：2005-08-05

Applicant: Luca Rastelli ,  Mary Kay Lescoe ,  Melissa Corso ,  Richard Kitson ,  Judith Landin ,  Lina Souan ,  Uriel M. Malyankar

Inventor： Luca Rastelli ,  Mary Kay Lescoe ,  Melissa Corso ,  Richard Kitson ,  Judith Landin ,  Lina Souan ,  Uriel M. Malyankar

IPC: A61K9/127 ,  C07K7/00 ,  A61K9/14 ,  C12N1/20 ,  A61P31/00 ,  C40B50/00 ,  C12N5/06 ,  A61K38/00

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/08

Abstract: Anti-angiogenic peptides that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR). Such peptides may also be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases and skin disorders.

Abstract translation: 公开了抑制VEGF介导的内皮细胞活化或增殖的抗血管生成肽。 这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）。 这样的肽也可以用于抑制VEGF介导的血管生成相关疾病如癌症，炎症性疾病，眼睛疾病和皮肤病中内皮细胞的活化。

公开(公告)号：US20060172941A1

公开(公告)日：2006-08-03

申请号：US11327849

申请日：2006-01-09

Applicant: Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

Inventor： Luca Rastelli ,  Judith Landin ,  Uriel Malyankar ,  Richard Kitson ,  Melissa Corso ,  Kenneth Brunson

IPC: A61K39/00 ,  C07K14/475

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K47/62 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

Abstract: Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

Abstract translation: 公开了抑制内皮细胞活化或增殖的抗血管生成肽。 这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）和bFGF与其受体的结合。 这些肽也可用于抑制血管生成相关疾病如癌症，白血病，多发性骨髓瘤，炎性疾病，眼睛疾病和皮肤疾病中的VEGF，bFGF或整合素激活内皮细胞。