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公开(公告)号：US20080287349A1
公开(公告)日：2008-11-20
申请号：US10980458
申请日：2004-11-03
申请人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
发明人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
IPC分类号： A61K38/17 , A61K31/711 , C07H21/04 , C12N15/63 , C12N5/06 , C12N1/00 , C12P21/00 , C07K14/00 , A61P19/00 , A61P19/02
CPC分类号： A61K38/1825 , A61K31/711 , C07K14/50
摘要： The present invention relates to compositions and methods for preventing and treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases). More particularly, the present invention provides methods for preventing and/or treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases) by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译： 本发明涉及用于预防和治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的组合物和方法。 更具体地，本发明通过使用包含FGF的组合物提供了预防和/或治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的方法 -20，片段，衍生物，变体，同系物或其类似物。
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公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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3.发明申请Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US20050084449A1
公开(公告)日：2005-04-21
申请号：US10805177
申请日：2004-03-19
申请人： Gregory Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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4.发明申请ANTIBODIES AGAINST T CELL IMMUNOGLOBULIN DOMAIN AND MUCIN DOMAIN 1 (TIM-1) ANTIGEN AND USES THEREOF 有权针对T细胞免疫球蛋白域和MUCIN域1（TIM-1）抗原的抗体及其用途公开(公告)号：US20120251555A1
公开(公告)日：2012-10-04
申请号：US13305898
申请日：2011-11-29
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： C07K16/28 , C12N5/10 , A61P35/00 , A61K39/395 , G01N33/574 , G01N21/64 , C12N5/16 , C12N5/09
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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5.发明授权Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US08067544B2
公开(公告)日：2011-11-29
申请号：US10805177
申请日：2004-03-19
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： C07K16/00
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20080009439A1
公开(公告)日：2008-01-10
申请号：US10578234
申请日：2004-11-03
IPC分类号： A61K38/00 , A61P43/00 , C07K14/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12P21/04 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/50 , C12Q2600/156 , C12Q2600/158 , G01N33/5044 , G01N33/6893 , G01N33/74 , G01N2800/06 , G01N2800/065 , G01N2800/102 , G01N2800/105 , G01N2800/20 , G01N2800/24 , G01N2800/2871 , G01N2800/40
摘要： The present invention generally relates to compositions and methods of use for a fibroblast growth factor (“FGF”). More particularly, the present invention relates to a nucleotide polymorphism (SNP) of FGF-20, and its fragments, derivatives, variants, homologs, and analogs, as well as their uses in wound healing, and prevention and/or treatment of certain diseases, including but are not limited to, stroke, radiation sickness, mucositis, inflammatory bowel disease, and inflammation (osteoarthritis and rheumatoid arthritis).
摘要翻译： 本发明一般涉及用于成纤维细胞生长因子（“FGF”）的组合物和方法。 更具体地，本发明涉及FGF-20的核苷酸多态性（SNP）及其片段，衍生物，变体，同系物和类似物，以及它们在伤口愈合中的用途以及预防和/或治疗某些疾病 包括但不限于中风，放射病，粘膜炎，炎性肠病和炎症（骨关节炎和类风湿性关节炎）。
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公开(公告)号：US20060141565A1
公开(公告)日：2006-06-29
申请号：US11005836
申请日：2004-12-06
申请人： Meera Patturajan , Isabelle Millet , Sampath Kumar , Charles Miller , Peter Mezes , Denise Lepley , Catherine Burgess , Richard Shimkets
发明人： Meera Patturajan , Isabelle Millet , Sampath Kumar , Charles Miller , Peter Mezes , Denise Lepley , Catherine Burgess , Richard Shimkets
CPC分类号： C07K14/50
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-22), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译： 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-22）或其片段，衍生物，变体，同源物，类似物或其组合的核酸分子，蛋白质和抗体。
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8.发明授权Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US09580503B2
公开(公告)日：2017-02-28
申请号：US13305898
申请日：2011-11-29
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US08846873B2
公开(公告)日：2014-09-30
申请号：US13355366
申请日：2012-01-20
申请人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译： 本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。 提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。 本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。 本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。
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公开(公告)号：US20130022597A1
公开(公告)日：2013-01-24
申请号：US13355366
申请日：2012-01-20
申请人： Meina Liang , Orit Foord , Scott Klakamp , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： A61K39/395 , C12N15/13 , C40B30/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译： 本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。 提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。 本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。 本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。
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