公开(公告)号：US09580503B2

公开(公告)日：2017-02-28

申请号：US13305898

申请日：2011-11-29

申请人： Gregory M. Landes ,  Francine Chen ,  Binyam Bezabeh ,  Ian Foltz ,  Kam Fai Tse ,  Michael Jeffers ,  Mehdi Mesri ,  Gary Starling ,  Peter Mezes ,  Nikolia Khramtsov

发明人： Gregory M. Landes ,  Francine Chen ,  Binyam Bezabeh ,  Ian Foltz ,  Kam Fai Tse ,  Michael Jeffers ,  Mehdi Mesri ,  Gary Starling ,  Peter Mezes ,  Nikolia Khramtsov

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2803 ,  A61K51/1039 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/574 ,  G01N2333/70503

摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US09087262B2

公开(公告)日：2015-07-21

申请号：US13293845

申请日：2011-11-10

申请人： Francine Chen ,  Jayant Kumar

发明人： Francine Chen ,  Jayant Kumar

IPC分类号： G06K9/40 ,  G06T7/00

CPC分类号： G06K9/40 ,  G06K2209/01 ,  G06T7/0002 ,  G06T2207/30176

摘要： Systems and methods described herein are directed to estimating the sharpness of images or photos such as document pages or scenes. The systems and methods are based on calculating a difference in grayscale values between pixels at an edge of an image. The differences may be accomplished by taking a slope of grayscale values between two pixels at an edge window, and estimating the edge sharpness based on the slope, multiple slopes, or differences in the slopes.

摘要翻译： 本文描述的系统和方法旨在估计诸如文档页面或场景的图像或照片的清晰度。 系统和方法基于计算图像边缘上的像素之间的灰度值的差异。 这些差异可以通过在边缘窗口处的两个像素之间取灰度值的斜率来完成，并且基于斜率，多个斜率或斜率的差异来估计边缘锐度。

公开(公告)号：US08634644B2

公开(公告)日：2014-01-21

申请号：US12547396

申请日：2009-08-25

申请人： Patrick Chiu ,  Francine Chen ,  Laurent Denoue

发明人： Patrick Chiu ,  Francine Chen ,  Laurent Denoue

IPC分类号： G06K9/34 ,  G06K9/46 ,  G06K7/10

CPC分类号： G06K9/00456

摘要： A system and method to identify pictures in documents. An image representing a page of a document is received. The image is analyzed to identify text objects in the page. A masked image is generated by masking out regions of the image including the text objects in the page. Groups of pixels in the masked image are identified, wherein a respective group of pixels corresponds to at least one picture in the page. When there is one or more groups of pixels, regions for pictures are identified based on the one or more groups of pixels. Metadata tags for the pictures are stored, wherein a respective metadata tag for a respective picture includes information about a respective bounding box for the respective picture.

摘要翻译： 用于识别文档中的图片的系统和方法。 接收表示文档的页面的图像。 分析图像以识别页面中的文本对象。 通过屏蔽包括页面中的文本对象的图像的区域来生成屏蔽图像。 识别掩蔽图像中的像素组，其中相应的像素组对应于页面中的至少一个图像。 当存在一个或多个像素组时，基于一个或多个像素组来识别用于图像的区域。 存储用于图像的元数据标签，其中相应图像的相应元数据标签包括关于相应图像的相应边界框的信息。

公开(公告)号：US20050144067A1

公开(公告)日：2005-06-30

申请号：US10742380

申请日：2003-12-19

申请人： Ayman Farahat ,  Hermann Calabria ,  Francine Chen ,  Daniel Greene

发明人： Ayman Farahat ,  Hermann Calabria ,  Francine Chen ,  Daniel Greene

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q30/0254 ,  G06Q30/0269 ,  G06Q30/0275 ,  G06Q30/08

摘要： A method for generating or determining data sources useful for detecting non-conforming behavior associated with pay-per-click advertising in a keyword searching environment includes: a) observing behavior associated with the pay-per-click advertising, b) predicting behavior associated with the observed behavior, and c) comparing the observed behavior to the predicted behavior to identify unexpected behavior associated with the pay-per-click advertising. In another embodiment, a method of monitoring behavior associated with targeted advertising in a keyword searching environment is provided. In another aspect, an apparatus for monitoring behavior associated with targeted advertising in a keyword searching environment includes: at least one observed behavior model, at least one predicted behavior model, and at least one comparator logic process to identify non-confirming behavior associated with the targeted advertising.

摘要翻译： 用于生成或确定用于检测与关键词搜索环境中的每次点击付费广告相关联的不符合行为的数据源的方法包括：a）观察与每次点击付费广告相关联的行为，b）预测与 观察到的行为，以及c）将观察到的行为与预测行为进行比较，以识别与每次点击付费广告相关联的意外行为。 在另一个实施例中，提供了一种在关键词搜索环境中监视与目标广告相关联的行为的方法。 在另一方面，一种用于监视与关键字搜索环境中的目标广告相关联的行为的装置包括：至少一个观察行为模型，至少一个预测行为模型以及至少一个比较器逻辑过程，以识别与 有针对性的广告。

公开(公告)号：US20050144065A1

公开(公告)日：2005-06-30

申请号：US10741354

申请日：2003-12-19

申请人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

发明人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q30/0272 ,  G06Q30/0275 ,  G06Q30/08 ,  G06Q40/04

摘要： A method of coordinating one or more bids for one or more groups of advertisers for placement of at least one advertisement in association with a search results list is provided. The search results list is generated in response to a search query. The method includes: a) collecting information from at least two advertisers in the advertiser group and b) devising a joint strategy for the advertiser group for bidding in the keyword auction. In another embodiment, a method of generating a bid for a first advertiser for placement of a first advertisement in association with a search results list is provided. In another embodiment, an apparatus for generating the bid for the first advertiser is provided. Is still another embodiment, a method of coordinating bids from a first advertiser and a second advertiser for placement of at least one advertisement in association with a first search results list is provided.

摘要翻译： 提供了一种协调一个或多个广告商组的一个或多个出价以放置与搜索结果列表相关联的至少一个广告的方法。 搜索结果列表是响应于搜索查询生成的。 该方法包括：a）从广告商组中的至少两个广告客户收集信息，以及b）为广告主组织设计关键字竞价中的出价的联合策略。 在另一个实施例中，提供了一种生成针对第一广告商的投标以便与搜索结果列表相关联地放置第一广告的方法。 在另一个实施例中，提供了用于为第一广告主生成出价的装置。 还是另一个实施例，提供了一种协调来自第一广告商和第二广告商的出价以便放置与第一搜索结果列表相关联的至少一个广告的方法。

公开(公告)号：US20050021324A1

公开(公告)日：2005-01-27

申请号：US10626856

申请日：2003-07-25

申请人： Thorsten Brants ,  Francine Chen ,  Ayman Farahat

发明人： Thorsten Brants ,  Francine Chen ,  Ayman Farahat

IPC分类号： G06F17/27

CPC分类号： G06F17/2785 ,  Y10S707/99936

摘要： Techniques for new event detection are provided. For a new story and a corpus of stories, story-pairs based on the new story and each corpus story are determined. Adjustments to the importance of terms are determined based on story characteristics associated with each story. Story characteristics are based on direct or indirect characteristics. Direct story characteristics include authorship, language associated with a story and the like. Indirect story characteristics may include derived characteristics such as an ROI category characteristic, a same ROI characteristic, a same event-same source characteristic, an average story similarity characteristic or any other known or later developed characteristic associated with a story. Adjustments to the inter-story similarity metrics are then determined based on story characteristics and/or a weighting function. New event scores and/or new event categorizations for stories are determined based on the inter-story similarity metrics and the adjustments based on the story characteristics. Optionally new events are selected based on new event scores and a threshold value.

摘要翻译： 提供了新的事件检测技术。 对于一个新故事和一组故事，基于新故事和每个语料库故事的故事对决定。 根据与每个故事相关的故事特征来确定术语重要性的调整。 故事特征基于直接或间接的特征。 直接故事特征包括作者身份，与故事相关的语言等。 间接故事特征可以包括衍生特征，例如ROI类别特征，相同的ROI特征，相同的事件相同的源特征，平均故事相似性特征或与故事相关联的任何其他已知或未来发展的特征。 然后基于故事特征和/或加权函数来确定对故事间相似性度量的调整。 基于故事间的相似性度量和基于故事特征的调整来确定故事的新事件评分和/或新事件分类。 可选地，基于新事件得分和阈值来选择新的事件。

公开(公告)号：US08601393B2

公开(公告)日：2013-12-03

申请号：US12242757

申请日：2008-09-30

申请人： Scott Carter ,  Francine Chen ,  Patrick Chiu

发明人： Scott Carter ,  Francine Chen ,  Patrick Chiu

IPC分类号： G06F17/00 ,  G06F3/00

CPC分类号： G06F3/0481

摘要： Described is a system that characterizes segments of a document with one or more keyphrases and then uses the keyphrases to help users find interesting parts of a document. The keyphrases are displayed with information about the location of the phrase in the document and are used as pointers to quickly move to from an overview to a section of potential interest.

摘要翻译： 描述了一种使用一个或多个关键短语表征文档段的系统，然后使用关键短语来帮助用户找到文档的有趣部分。 关键短语显示有关短语在文档中的位置的信息，并且用作快速从概览迁移到潜在兴趣部分的指针。

公开(公告)号：US20120209751A1

公开(公告)日：2012-08-16

申请号：US13025960

申请日：2011-02-11

申请人： Francine Chen ,  Scott Carter ,  Aditi Shrikumar ,  Jeremy Pickens

发明人： Francine Chen ,  Scott Carter ,  Aditi Shrikumar ,  Jeremy Pickens

IPC分类号： G06Q30/00

CPC分类号： G06Q30/06

摘要： Systems and methods are directed to use-based product searching. Raw product information data, such as product features, specifications, and user reviews are processed and analyzed using pattern-based text analysis to extract relevant product aspects and uses. The aspects are weighted in relation to their importance for various uses, and the corresponding aspects and their weights are linked to the uses. A user selects uses for a product, which correspond to weighted aspects, and the weights for the aspects are used to rank products using the weights of the aspects linked to the selected uses. The ranked products are presented to the user in a customizable interface. The user may directly specify weights for the extracted aspects to further customize the ranked list of products. The interface provides additional options for viewing product details, opinions and comparisons.

摘要翻译： 系统和方法针对基于使用的产品搜索。 使用基于模式的文本分析处理和分析原始产品信息数据，如产品功能，规格和用户评论，以提取相关的产品方面和用途。 这些方面与其对各种用途的重要性有关，相应的方面和权重与用途有关。 用户选择对应于加权方面的产品的使用，并且使用方面的权重来使用与所选择的使用相关联的方面的权重来对产品进行排序。 排名的产品在可定制的界面中呈现给用户。 用户可以直接指定提取的方面的权重，以进一步定制产品的排名列表。 该界面提供了查看产品详细信息，意见和比较的其他选项。

公开(公告)号：US07572444B2

公开(公告)日：2009-08-11

申请号：US11303608

申请日：2005-12-16

申请人： Ian Foltz ,  Chadwick King ,  Peter Koon Bong Ling ,  Jaspal Singh Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Darne Scatena ,  Bruce A. Keyt ,  Edwin Madison ,  Wayne R. Godfrey ,  Stanislaw K. Morkowski ,  Jennifer H. Richardson

发明人： Ian Foltz ,  Chadwick King ,  Peter Koon Bong Ling ,  Jaspal Singh Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Darne Scatena ,  Bruce A. Keyt ,  Edwin Madison ,  Wayne R. Godfrey ,  Stanislaw K. Morkowski ,  Jennifer H. Richardson

IPC分类号： A61K39/395 ,  A61K51/00 ,  C07H21/04 ,  C12N5/06 ,  C12P21/06

CPC分类号： C07K16/40 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2500/04

摘要： Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.

摘要翻译： 公开了涉及抗原Matriptase的结合蛋白，例如完全人单克隆抗体及其片段，以及这些结合蛋白的用途。 还公开了编码和包含能够结合Matriptase的重链和轻链免疫球蛋白分子的氨基酸序列的核苷酸序列。 本发明还公开了表达这种免疫球蛋白分子的细胞系和对Matriptase的单克隆抗体。 抗体可用于检测，预防和治疗诸如癌症的疾病。

公开(公告)号：US20090080853A1

公开(公告)日：2009-03-26

申请号：US11860436

申请日：2007-09-24

申请人： Francine CHEN ,  Matthew Cooper ,  John Adcock

发明人： Francine CHEN ,  Matthew Cooper ,  John Adcock

IPC分类号： G11B27/00

CPC分类号： G11B27/28 ,  G06F17/30787 ,  G06F17/30802 ,  G06F17/30811 ,  G06F17/30843

摘要： The subject invention relates to a system and method for video summarization, and more specifically to a system for segmenting and classifying data from a video in order to create a summary video that preserves and summarizes relevant content. In one embodiment, the system first extracts appearance, motion, and audio features from a video in order to create video segments corresponding to the extracted features. The video segments are then classified as dynamic or static depending on the appearance-based and motion-based features extracted from each video segment. The classified video segments are then grouped into clusters to eliminate redundant content. Select video segments from each cluster are selected as summary segments, and the summary segments are compiled to form a summary video. The parameters for any of the steps in the summarization of the video can be altered so that a user can adapt the system to any type of video, although the system is designed to summarize unstructured videos where the content is unknown. In another aspect, audio features can also be used to further summarize video with certain audio properties.

摘要翻译： 本发明涉及一种用于视频摘要的系统和方法，更具体地涉及一种用于从视频中分割和分类数据以便创建保留和总结相关内容的摘要视频的系统。 在一个实施例中，系统首先从视频中提取外观，运动和音频特征，以便创建对应于所提取的特征的视频段。 视频片段根据从每个视频段中提取的基于外观和基于运动的特征，被分类为动态或静态。 然后将分类的视频片段分组成簇以消除冗余内容。 选择每个群集中的视频片段作为摘要片段，并将摘要片段编译为一个摘要视频。 视频总结中的任何步骤的参数可以被改变，使得用户可以使系统适应任何类型的视频，尽管系统被设计为总结内容未知的非结构化视频。 另一方面，也可以使用音频特征来进一步总结具有某些音频属性的视频。