公开(公告)号：US08779108B2

公开(公告)日：2014-07-15

申请号：US13511538

申请日：2010-11-24

申请人： Christophe Queva ,  Michelle Morrow ,  Scott Hammond ,  Marat Alimzhanov ,  John Babcook ,  Ian Nevin Foltz ,  Jaspal Singh Kang ,  Laura Sekirov ,  Melanie Boyle ,  Matthieu Chodorge ,  Ross A. Stewart ,  Kathleen Ann Mulgrew

发明人： Christophe Queva ,  Michelle Morrow ,  Scott Hammond ,  Marat Alimzhanov ,  John Babcook ,  Ian Nevin Foltz ,  Jaspal Singh Kang ,  Laura Sekirov ,  Melanie Boyle ,  Matthieu Chodorge ,  Ross A. Stewart ,  Kathleen Ann Mulgrew

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  C07H21/04 ,  C12N5/16 ,  A61K39/00

CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92

摘要： Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

摘要翻译： 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外，公开了表达这种抗体的杂交瘤或其它细胞系。

公开(公告)号：US08569459B2

公开(公告)日：2013-10-29

申请号：US13478580

申请日：2012-05-23

申请人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

发明人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07H21/04

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

摘要翻译： 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。

公开(公告)号：US08431130B2

公开(公告)日：2013-04-30

申请号：US12843740

申请日：2010-07-26

申请人： Tariq Ghayur ,  Boris Labkovsky ,  Jeffrey W. Voss ,  Larry Green ,  John Babcook ,  Xiao-chi Jia ,  James Wieler ,  Jaspal Singh Kang ,  Brad Hedberg

发明人： Tariq Ghayur ,  Boris Labkovsky ,  Jeffrey W. Voss ,  Larry Green ,  John Babcook ,  Xiao-chi Jia ,  James Wieler ,  Jaspal Singh Kang ,  Brad Hedberg

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C12P21/08

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07H21/04 ,  C07K2317/21

摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。

公开(公告)号：US20120328625A1

公开(公告)日：2012-12-27

申请号：US13478580

申请日：2012-05-23

申请人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

发明人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

摘要翻译： 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。

公开(公告)号：US08012714B2

公开(公告)日：2011-09-06

申请号：US12423594

申请日：2009-04-14

申请人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

发明人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

IPC分类号： C12N15/00 ,  C12N15/11 ,  C12N5/06 ,  C12P21/08

CPC分类号： C07K16/00 ,  C07K2317/56 ,  C12N15/113 ,  C12N2310/14

摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.

摘要翻译： 公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件 重组。 公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

公开(公告)号：US20140314784A1

公开(公告)日：2014-10-23

申请号：US14232751

申请日：2012-07-19

申请人： Vahe Bedian ,  Youzhen Wang ,  Ian Foltz ,  Palaniswami Rathanaswami ,  Jaspal Singh Kang ,  Adeela Kamal ,  Philipp Steiner

发明人： Vahe Bedian ,  Youzhen Wang ,  Ian Foltz ,  Palaniswami Rathanaswami ,  Jaspal Singh Kang ,  Adeela Kamal ,  Philipp Steiner

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC分类号： C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure relates to antibodies or antigen binding fragments that specifically bind to CXCR4 and inhibit the biological activity of CXCR4 and uses of such agents. More specifically the disclosure relates to fully human antibodies or antigen binding fragments directed to CXCR4 that specifically bind to CXCR4 and uses of these antibodies. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies. The disclosed antibodies (including antigen binding fragments) are useful as diagnostics and for the treatment of diseases associated with the activity and/or expression of CXCR4.

摘要翻译： 本公开涉及特异性结合CXCR4并抑制CXCR4的生物学活性的抗体或抗原结合片段以及这些试剂的用途。 更具体地，本公开涉及针对CXCR4的完全人抗体或抗原结合片段，其特异性结合CXCR4和这些抗体的用途。 本公开的方面还涉及表达这种抗体的杂交瘤或其它细胞系。 所公开的抗体（包括抗原结合片段）可用作诊断和治疗与CXCR4的活性和/或表达相关的疾病。

公开(公告)号：US08697664B2

公开(公告)日：2014-04-15

申请号：US12708022

申请日：2010-02-18

申请人： Naomi Laing ,  Jaspal Singh Kang ,  Ian Foltz ,  Gadi Gazit-Bornstein ,  Xiao-Dang Yang ,  Sue A. Cartlidge ,  David Charles Blakey

发明人： Naomi Laing ,  Jaspal Singh Kang ,  Ian Foltz ,  Gadi Gazit-Bornstein ,  Xiao-Dang Yang ,  Sue A. Cartlidge ,  David Charles Blakey

IPC分类号： C12N15/13 ,  C12N5/10 ,  C07H21/04 ,  A61K31/70

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to the antigen PDGFR-alpha and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The described targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of PDGFR-alpha.

摘要翻译： 本文公开了针对抗原PDGFR-α的靶向结合剂及其用途。 更具体地，本发明涉及针对抗原PDGFR-α的完全人单克隆抗体以及这些抗体的用途。 本发明的方面还涉及表达这种抗体的杂交瘤或其它细胞系。 所描述的靶向结合剂和抗体可用作诊断和治疗与PDGFR-α的活性和/或过度表达相关的疾病。

公开(公告)号：US20100196388A1

公开(公告)日：2010-08-05

申请号：US12562435

申请日：2009-09-18

申请人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

发明人： David Jenkins ,  Neil Michaud ,  Naomi Laing ,  Jaspal Singh Kang

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/04 ,  A61P35/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

摘要翻译： 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。

公开(公告)号：US20090258392A1

公开(公告)日：2009-10-15

申请号：US12423594

申请日：2009-04-14

申请人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

发明人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

IPC分类号： C12P21/08 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

CPC分类号： C07K16/00 ,  C07K2317/56 ,  C12N15/113 ,  C12N2310/14

摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.

摘要翻译： 公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件 重组。 公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

公开(公告)号：US20130236931A1

公开(公告)日：2013-09-12

申请号：US13765484

申请日：2013-02-12

申请人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

发明人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

IPC分类号： C12P21/00

CPC分类号： C12P21/00 ,  C07K16/00 ,  C07K2317/56 ,  C12N15/102 ,  C12N15/113 ,  C12N2310/14

摘要： An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s).

摘要翻译： 描述了用于产生序列的体外系统，因此蛋白质的结构多样性。 可以使用适当选择的编码所选蛋白质或蛋白质区域的重组信号序列（RSS）的核酸分子来构建该系统。 所选择的蛋白可以是例如免疫球蛋白（Ig）V，D，J和/或C区，非免疫球蛋白（非Ig）蛋白的区域，或Ig区和非Ig的组合 地区。 组装这些适当选择的组分并将其引入合适的可重组的宿主细胞中允许RSS序列之间的重组，并将序列和结构多样性引入到蛋白质中。