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    SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS
    1.
    发明申请
    SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS 审中-公开
    免疫球蛋白和其他蛋白质的序列多样性生成

    公开(公告)号：US20130236931A1

    公开(公告)日：2013-09-12

    申请号：US13765484

    申请日：2013-02-12

    申请人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

    发明人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

    IPC分类号： C12P21/00

    CPC分类号： C12P21/00 ,  C07K16/00 ,  C07K2317/56 ,  C12N15/102 ,  C12N15/113 ,  C12N2310/14

    摘要： An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s).

    摘要翻译： 描述了用于产生序列的体外系统，因此蛋白质的结构多样性。 可以使用适当选择的编码所选蛋白质或蛋白质区域的重组信号序列（RSS）的核酸分子来构建该系统。 所选择的蛋白可以是例如免疫球蛋白（Ig）V，D，J和/或C区，非免疫球蛋白（非Ig）蛋白的区域，或Ig区和非Ig的组合 地区。 组装这些适当选择的组分并将其引入合适的可重组的宿主细胞中允许RSS序列之间的重组，并将序列和结构多样性引入到蛋白质中。

    Human monoclonal antibodies to epidermal growth factor receptor
    2.
    发明申请
    Human monoclonal antibodies to epidermal growth factor receptor 审中-公开
    人表皮生长因子受体单克隆抗体

    公开(公告)号：US20050100546A1

    公开(公告)日：2005-05-12

    申请号：US11021795

    申请日：2004-12-22

    申请人： Aya Jakobovits ,  Xiao-Dong Yang ,  Michael Gallo ,  Xiao-Chi Jia

    发明人： Aya Jakobovits ,  Xiao-Dong Yang ,  Michael Gallo ,  Xiao-Chi Jia

    IPC分类号： A61K38/00 ,  C07K16/28 ,  A61K39/395

    CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/77

    摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.

    摘要翻译： 根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。 提供了含有重链和轻链免疫球蛋白分子的Nuclotide序列编码和氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。 根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解 ，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮 肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

    SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS
    3.
    发明申请
    SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS 有权
    免疫球蛋白中的序列多样性生成

    公开(公告)号：US20120258495A1

    公开(公告)日：2012-10-11

    申请号：US13205218

    申请日：2011-08-08

    申请人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

    发明人： Michael Gallo ,  Jaspal Singh Kang ,  Craig Robin Pigott

    IPC分类号： C12N5/10 ,  C12P21/00

    CPC分类号： C07K16/00 ,  C07K2317/56 ,  C12N15/113 ,  C12N2310/14

    摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.

    摘要翻译： 公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件 重组。 公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

    Locking device and method for unlocking the locking device
    5.
    发明授权
    Locking device and method for unlocking the locking device 有权
    用于解锁锁定装置的锁定装置和方法

    公开(公告)号：US07543468B2

    公开(公告)日：2009-06-09

    申请号：US12036442

    申请日：2008-02-25

    申请人： Kevin Houlihan ,  Patrick E. Wind ,  Michael Gallo

    发明人： Kevin Houlihan ,  Patrick E. Wind ,  Michael Gallo

    IPC分类号： E05B63/00 ,  E05B65/06

    CPC分类号： E05B65/025 ,  E05B1/0053 ,  E05B63/0065 ,  E05C9/026 ,  Y10T70/5124 ,  Y10T70/5345 ,  Y10T70/5363 ,  Y10T70/8459

    摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.

    摘要翻译： 提供了锁定装置和用于解锁锁定装置的方法。 锁定装置包括具有在其中延伸的第一孔的固定塞，其构造成接收钥匙。 固定塞还包括外表面，由第一孔限定的内表面和至少一个从外表面延伸到内表面的第二孔。 锁定装置还包括具有围绕固定塞的至少一部分设置的外壁的壳体。 外壁具有至少延伸穿过其中的第三孔。 锁定装置还包括可操作地联接到壳体的外壁的螺栓构件。 锁定装置还包括设置在壳体的第三孔中并延伸到固定塞的第二孔中的锁定机构。 锁定机构构造成当钥匙插入第一孔口时允许壳体围绕固定塞旋转。 壳体构造成响应于施加到螺栓构件的力而从第一操作位置旋转到第二操作位置。

    APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS
    6.
    发明申请
    APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 有权
    用于向消费者发放安全存储产品的装置和方法

    公开(公告)号：US20080134735A1

    公开(公告)日：2008-06-12

    申请号：US11938002

    申请日：2007-11-09

    申请人： Michael Gallo ,  Steve Sanelli

    发明人： Michael Gallo ,  Steve Sanelli

    IPC分类号： E05B63/14

    CPC分类号： E05B15/0046 ,  E05B13/004 ,  E05B15/101 ,  E05B35/12 ,  E05B47/023 ,  E05C3/24 ,  G07F7/0609 ,  Y10S70/62 ,  Y10S70/63 ,  Y10T70/625 ,  Y10T70/7441 ,  Y10T70/7768 ,  Y10T292/1047 ,  Y10T292/1062 ,  Y10T292/1078 ,  Y10T403/602

    摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for releasing the rotary latch from the locked position after actuation of the first lock mechanism, the biasing member rotating the rotary latch into the unlocked position, the rotary latch being capable of being manipulated back into the locked position from the unlocked position after release by the first locking mechanism and the first locking mechanism must be reset in order to once again release the rotary latch.

    摘要翻译： 公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置 锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在所述第一锁定机构致动之后将所述旋转闩锁从所述锁定位置释放，所述偏置构件将所述旋转闩锁旋转到所述解锁位置，所述旋转闩锁能够被解锁回锁定位置 必须复位通过第一锁定机构释放的位置和第一锁定机构以再次释放旋转闩锁。

    Human monoclonal antibodies to epidermal growth factor receptor
    7.
    发明申请
    Human monoclonal antibodies to epidermal growth factor receptor 有权
    人表皮生长因子受体单克隆抗体

    公开(公告)号：US20060183887A1

    公开(公告)日：2006-08-17

    申请号：US11267860

    申请日：2005-11-04

    申请人： Aya Jakobovits ,  Xiao-Dong Yang ,  Michael Gallo ,  Xiao-Chi Jia

    发明人： Aya Jakobovits ,  Xiao-Dong Yang ,  Michael Gallo ,  Xiao-Chi Jia

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/77

    摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.

    摘要翻译： 根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。 提供了含有重链和轻链免疫球蛋白分子的Nuclotide序列编码和氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。 根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解 ，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮 肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

    Frosting foils
    9.
    发明授权
    Frosting foils 失效
    结霜箔

    公开(公告)号：US5287864A

    公开(公告)日：1994-02-22

    申请号：US956119

    申请日：1992-10-05

    申请人： Michael Gallo

    发明人： Michael Gallo

    IPC分类号： A45D19/00 ,  A61K8/02 ,  A61Q5/10 ,  A61K7/13

    CPC分类号： A45D19/0025

    摘要： The present invention provides a frosting foil for use in connection with frosting and/or coloring a subject's hair. The frosting foil includes a sleeve, an adhesive surface, and a backing material. The sleeve is sized to receive the tail of a tail comb so that a stylist may pick up and properly place the foil at a strand of hair desired to be treated. The adhesive attaches the foil to the strand of hair to prevent movement of the foil. Further, the adhesive permits the foil to be folded into place so that all of the foils may be placed prior to the addition of any coloring agent. After placement of the foils, each foil may be sequentially opened and a coloring agent placed on the strand of the hair contained in the foil.

    摘要翻译： 本发明提供了一种结霜箔，用于与受试者头发结霜和/或着色。 结霜箔包括套筒，粘合剂表面和背衬材料。 套筒的尺寸设置成接收尾梳的尾部，使得造型师可以拾取并将箔适当地放置在期望被处理的头发线上。 粘合剂将箔粘附到头发束以防止箔的移动。 此外，粘合剂允许箔被折叠就位，使得所有箔可以在添加任何着色剂之前被放置。 在放置箔之后，可以依次打开每个箔，并且将着色剂放置在箔中包含的头发的股线上。

    Interpretation of free-form timelines into compositing instructions
    10.
    发明授权
    Interpretation of free-form timelines into compositing instructions 有权
    将自由格式的时间表解释为合成指令

    公开(公告)号：US09299389B2

    公开(公告)日：2016-03-29

    申请号：US13625540

    申请日：2012-09-24

    申请人： Michael Gallo

    发明人： Michael Gallo

    IPC分类号： G11B27/00 ,  G11B27/034 ,  G11B27/34

    CPC分类号： G11B27/034 ,  G11B27/34

    摘要： A method, system, and computer-readable storage medium are disclosed for interpretation of free-form timelines into compositing instructions. An array comprising a plurality of items is generated. Each of the plurality of items comprises one or more instructions representing one or more operations occurring at a point in time in a video sequence. For each one of a plurality of patterns, the array is scanned to determine if one or more groups of items in the array match the pattern. For each group of items matching one of the plurality of patterns, the matching group of items is replaced in the array with a merged item. Each merged item comprises an ordered sequence of the one or more instructions in the corresponding matching group of items. A frame of the video sequence is composited dependent on the array comprising the one or more merged items.

    摘要翻译： 公开了一种方法，系统和计算机可读存储介质，用于将自由形式时间线解释为合成指令。 生成包括多个项目的阵列。 多个项目中的每一个包括表示在视频序列中的某个时间点发生的一个或多个操作的一个或多个指令。 对于多个图案中的每个图案，扫描阵列以确定阵列中的一组或多组项目是否匹配图案。 对于与多个模式中的一个匹配的每个项目组，匹配的项目组在阵列中被替换为合并项目。 每个合并的项目包括相应匹配的项目组中的一个或多个指令的有序序列。 根据包含一个或多个合并项目的阵列来合成视频序列的帧。