Method for attaching a particle to a scanning probe tip through eutectic bonding
    1.
    发明授权
    Method for attaching a particle to a scanning probe tip through eutectic bonding 有权
    通过共晶接合将颗粒附着到扫描探针尖端的方法

    公开(公告)号:US08656511B2

    公开(公告)日:2014-02-18

    申请号:US12763614

    申请日:2010-04-20

    IPC分类号: G01Q60/40 G01Q60/38 G01Q70/18

    CPC分类号: G01Q60/40

    摘要: A method for attaching a conductive particle to the apex of a probe tip comprises the steps of: moving the apex of a probe tip close to a conductive particle and applying a bias voltage between the probe tip and the conductive particle so that the conductive particle can permanently attach to the apex. The method uses only a bias voltage to transfer and attach conductive particles to the apex of a probe tip, and no surface treatment of the probe tip is required.

    摘要翻译: 用于将导电粒子附着到探针尖端的顶点的方法包括以下步骤:将探针尖端的顶点靠近导电粒子移动并在探针尖端和导电粒子之间施加偏置电压,使得导电粒子可以 永久性地附着到顶点。 该方法仅使用偏置电压将导电颗粒转移并附着到探针尖端的顶点,并且不需要对探针尖端进行表面处理。

    FLUIDIC NANO/MICRO ARRAY CHIP AND CHIPSET THEREOF
    2.
    发明申请
    FLUIDIC NANO/MICRO ARRAY CHIP AND CHIPSET THEREOF 审中-公开
    流体纳米/微阵列芯片及其芯片

    公开(公告)号:US20080280785A1

    公开(公告)日:2008-11-13

    申请号:US12110551

    申请日:2008-04-28

    IPC分类号: C40B60/14

    摘要: A fluidic nano/micro array chipset comprises a microarray filling chip and a nano/micro array stamping chip. There are a plurality of sample containers and a plurality of nano/micro channels on the top of the microarray filling chip, and a plurality of nano/micro-scaled micro filling holes on the bottom of the microarray filling chip. Each nano/micro channel is connected to one of the sample containers and leads the sample solution in that sample container to the corresponding micro filling hole. The nano/micro array stamp chip comprises a plurality of stamping heads arranged in an array pattern, with a body part of the stamp chip and a plurality of space channels forming hydrophobic areas. Each sample solution is stored in the body of the stamp chip, and is transported by the corresponding stamping head to the stamping part of this stamping head.

    摘要翻译: 流体纳米/微阵列芯片组包括微阵列填充芯片和纳米/微阵列冲压芯片。 在微阵列填充芯片的顶部有多个样品容器和多个纳米/微通道,以及位于微阵列填充芯片底部的多个纳米/微尺度微量填充孔。 每个纳米/微通道连接到一个样品容器中,并将样品容器中的样品溶液引导到相应的微孔中。 纳米/微阵列印模芯片包括以阵列图案排列的多个冲压头,印模芯片的主体部分和形成疏水区域的多个空间通道。 每个样品溶液储存在印模芯片的主体中,并通过相应的冲压头传送到冲压头的冲压件。

    SINGLE MOLECULE DETECTION PLATFORM, MANUFACTURING METHOD THEREOF AND METHOD USING THE SAME
    3.
    发明申请
    SINGLE MOLECULE DETECTION PLATFORM, MANUFACTURING METHOD THEREOF AND METHOD USING THE SAME 有权
    单分子检测平台及其制造方法及其使用方法

    公开(公告)号:US20110117587A1

    公开(公告)日:2011-05-19

    申请号:US12944151

    申请日:2010-11-11

    IPC分类号: C12Q1/42 C12M1/34 B05D3/10

    摘要: A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface of the light-transmissive substrate is etched to form a plurality of cone-shaped structures. Each spherical particle is disposed on top of each cone-shaped structure. The sizes of the plurality of spherical particles are suitable to allow only a single protein to be attached to each spherical particle. The thin film is deposited on the surface of the plurality of cone-shaped structures and acts as a reflective layer of one-dimensional waveguide. The plurality of spherical particles is not covered by the thin film.

    摘要翻译: 公开了单分子检测平台。 单分子检测平台包括透光基板,多个球形颗粒和薄膜。 透光基板的表面被蚀刻以形成多个锥形结构。 每个球形颗粒设置在每个锥形结构的顶部。 多个球形颗粒的尺寸适合于仅允许单个蛋白质附着到每个球形颗粒上。 薄膜沉积在多个锥形结构的表面上并且用作一维波导的反射层。 多个球形颗粒不被薄膜覆盖。

    Portable optical detection chip and manufacturing method thereof
    4.
    发明授权
    Portable optical detection chip and manufacturing method thereof 失效
    便携式光学检测芯片及其制造方法

    公开(公告)号:US07851251B2

    公开(公告)日:2010-12-14

    申请号:US12794306

    申请日:2010-06-04

    IPC分类号: H01L21/00

    摘要: A portable optical detection chip comprises a substrate, a plurality of avalanche-type photosensitive device modules and a plurality of plane mirrors. The plurality of avalanche-type photosensitive device modules are formed on the substrate, and each of them comprises a plurality of avalanche-type photosensitive devices and a plurality of lenses. Each of the lenses is stacked on one of the avalanche-type photosensitive devices. The plurality of plane mirrors are disposed between the avalanche-type photosensitive device modules. That is, the avalanche-type photosensitive device modules are separated from each other by the plane mirrors.

    摘要翻译: 便携式光学检测芯片包括基板,多个雪崩型光敏器件模块和多个平面镜。 多个雪崩型光敏元件模块形成在基板上,并且它们各自包括多个雪崩型光敏元件和多个透镜。 每个透镜都堆叠在雪崩型感光装置中的一个上。 多个平面镜设置在雪崩型光敏器件模块之间。 也就是说,雪崩型光敏器件模块通过平面镜彼此分离。

    Biochip and manufacturing method thereof
    5.
    发明授权
    Biochip and manufacturing method thereof 有权
    生物芯片及其制造方法

    公开(公告)号:US08802024B2

    公开(公告)日:2014-08-12

    申请号:US11864164

    申请日:2007-09-28

    摘要: A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first self-assembled monolayer by micro-titration technique. After the bonding reaction between the first biomedical molecular point and the first self-assembled monolayer, a second self-assembled monolayer is deposited on the surface of the first self-assembled monolayer by evaporation. The second self-assembled monolayer attached on the plurality of first biomedical molecular dots and the first self-assembled monolayer not bonded to the substrate are removed, so that the first biomedical molecular dots immobilized on the first self-assembled monolayer are exposed. Finally, a second biomedical molecular layer is immobilized on the exposed portions of the first biomedical molecular dots.

    摘要翻译: 提供一种制造生物芯片的方法。 首先,将第一自组装单层涂覆在基材上。 接下来,通过微滴定技术在第一自组装单层上形成多个第一生物医学分子点。 在第一生物医学分子点和第一自组装单层之间的结合反应之后,第二自组装单层通过蒸发沉积在第一自组装单层的表面上。 去除附着在多个第一生物医学分子点上的第二自组装单层和未结合到基底的第一自组装单层,使得固定在第一自组装单层上的第一生物医学分子点被暴露。 最后,将第二生物医学分子层固定在第一生物医学分子点的暴露部分上。

    Immunodetection probe and method of immunodetection using the same
    6.
    发明授权
    Immunodetection probe and method of immunodetection using the same 有权
    免疫检测探针和免疫检测方法

    公开(公告)号:US08785136B2

    公开(公告)日:2014-07-22

    申请号:US12917706

    申请日:2010-11-02

    摘要: An immunodetection probe comprises a needle structure having a compartment and configured to be inserted into an organic tissue, a dialysis membrane configured to isolate the compartment from the organic tissue, a detection device having a detection portion and a plurality of receptors, a first optical fiber coupled to the needle structure, and a pair of tubes connected to the compartment. The plurality of receptors are disposed on an end surface of the detection portion for conjugating target antibodies, wherein the detection portion is disposed in the compartment. The first optical fiber is configured to introduce light incident on photo-induced molecules adjacent to the end surface of the detection portion so as to cause a change in the pH level of the solution adjacent to the end surface of the detection portion. The pair of tubes is configured to transport the solution containing the photo-induced molecules into the compartment.

    摘要翻译: 免疫检测探针包括具有隔室并构造成插入有机组织的针结构,被配置为将隔室与有机组织隔离的透析膜,具有检测部分和多个受体的检测装置,第一光纤 连接到针结构,以及连接到隔室的一对管。 多个受体被设置在检测部分的端表面上,用于共轭靶抗体,其中检测部分设置在隔室中。 第一光纤被配置为引入入射到与感测部分的端表面相邻的光致分子上的光,以引起邻近检测部分的端面的溶液的pH值的变化。 这对管被配置为将含有光诱导分子的溶液输送到隔室中。

    Multi-dimensional data registration integrated circuit for driving array-arrangement devices
    7.
    发明授权
    Multi-dimensional data registration integrated circuit for driving array-arrangement devices 有权
    用于驱动阵列布置器件的多维数据注册集成电路

    公开(公告)号:US08625153B2

    公开(公告)日:2014-01-07

    申请号:US12480332

    申请日:2009-06-08

    IPC分类号: G06K15/10

    CPC分类号: B41J2/04586 B41J2/04541

    摘要: A multi-dimensional data registration integrated circuit is configured for driving array-arrangement devices. The array-arrangement devices comprise a plurality of first hierarchy sets, each which comprises a plurality of second hierarchy sets. The multi-dimensional data registration integrated circuit comprises a first hierarchy address selection circuit, a second hierarchy address selection circuit and a data supply circuit. The first hierarchy address selection circuit scans the first hierarchy sets, and selects a unit of the first hierarchy sets to activate it. The second hierarchy address selection circuit scans the second hierarchy sets. The data supply circuit writes a plurality of data into each designated unit of the second hierarchy sets according to the scanning sequence of the second hierarchy address selection circuit.

    摘要翻译: 多维数据配准集成电路被配置用于驱动阵列布置装置。 阵列布置装置包括多个第一层次集合,每一组包括多个第二层次集合。 多维数据登记集成电路包括第一层地址选择电路,第二层地址选择电路和数据提供电路。 第一层次地址选择电路扫描第一层次集合,并选择第一层集合的单位以激活它。 第二层地址选择电路扫描第二层次集合。 数据供给电路根据第二层地址选择电路的扫描顺序将多个数据写入到第二层次组的每个指定单元中。

    Single molecule detection platform, manufacturing method thereof and method using the same
    8.
    发明授权
    Single molecule detection platform, manufacturing method thereof and method using the same 有权
    单分子检测平台及其制造方法及其使用方法

    公开(公告)号:US08501428B2

    公开(公告)日:2013-08-06

    申请号:US12944151

    申请日:2010-11-11

    IPC分类号: C12Q1/66 C12Q1/42 G01N21/64

    摘要: A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface of the light-transmissive substrate is etched to form a plurality of cone-shaped structures. Each spherical particle is disposed on top of each cone-shaped structure. The sizes of the plurality of spherical particles are suitable to allow only a single protein to be attached to each spherical particle. The thin film is deposited on the surface of the plurality of cone-shaped structures and acts as a reflective layer of one-dimensional waveguide. The plurality of spherical particles is not covered by the thin film.

    摘要翻译: 公开了单分子检测平台。 单分子检测平台包括透光基板,多个球形颗粒和薄膜。 透光基板的表面被蚀刻以形成多个锥形结构。 每个球形颗粒设置在每个锥形结构的顶部。 多个球形颗粒的尺寸适合于仅允许单个蛋白质附着到每个球形颗粒上。 薄膜沉积在多个锥形结构的表面上并且用作一维波导的反射层。 多个球形颗粒不被薄膜覆盖。

    Electrode structure capable of separate delivering gas and fluid and passive fuel cell using the same
    9.
    发明授权
    Electrode structure capable of separate delivering gas and fluid and passive fuel cell using the same 有权
    能够使用其分离输送气体和流体的电极结构和被动燃料电池

    公开(公告)号:US08802327B2

    公开(公告)日:2014-08-12

    申请号:US13043387

    申请日:2011-03-08

    IPC分类号: H01M8/02

    摘要: The present invention discloses an electrode structure capable of separately delivering gas and fluid which is applied to a passive fuel cell. The electrode structure includes an electrode portion and a water removal plate, and the electrode portion is adjacent to the water removal plate. The water removal plate includes a first surface, a second surface opposite to the first surface, a plurality of gas passages passing from the first surface to the second surface, and a plurality of liquid passages disposed on the first surface. The surfaces of the gas passages are treated with hydrophobic treatment, and the surfaces of the liquid passages are treated with hydrophilic treatment.

    摘要翻译: 本发明公开了一种电极结构,其能够分别输送施加到无源燃料电池的气体和流体。 电极结构包括电极部分和除水板,电极部分与除水板相邻。 除水板包括第一表面,与第一表面相对的第二表面,从第一表面到第二表面的多个气体通道,以及设置在第一表面上的多个液体通道。 用疏水处理处理气体通道的表面,并用亲水处理处理液体通道的表面。

    Micro-droplet ejection apparatus having nozzle arrays without individual chambers and ejection method of droplets thereof
    10.
    发明授权
    Micro-droplet ejection apparatus having nozzle arrays without individual chambers and ejection method of droplets thereof 有权
    具有不具有各个室的喷嘴阵列的微滴喷射装置和其液滴的喷射方法

    公开(公告)号:US08287102B2

    公开(公告)日:2012-10-16

    申请号:US12042675

    申请日:2008-03-05

    IPC分类号: B41J2/05

    摘要: A micro-droplet ejection apparatus includes a substrate, a droplet-ejecting layer, and a plurality of bubble generators. A liquid storage space is formed between the substrate and the droplet-ejecting layer. The liquid storage space has no spacer connecting the substrate and the droplet-ejecting layer. That is, the liquid storage space has no individual chambers. The droplet-ejecting layer has a plurality of through holes arranged in an array, and each through hole is used as a nozzle for pushing out ink. The plurality of bubble generators is disposed above the substrate, and corresponds to and is disposed under the through holes. The bubble generators on two sides of a designated bubble generator generate at least one limit bubble, limiting the growth of a main bubble generated by the designated bubble generator.

    摘要翻译: 微滴喷射装置包括基板,液滴喷射层和多个气泡发生器。 在基板和液滴喷射层之间形成液体储存空间。 液体储存空间没有连接衬底和液滴喷射层的间隔物。 也就是说,液体储存空间没有单独的室。 液滴喷射层具有排列成阵列的多个通孔,并且每个通孔用作用于推出墨水的喷嘴。 多个气泡生成器设置在基板上方,并且对应于并设置在通孔下方。 指定气泡发生器两侧的气泡生成器产生至少一个限制气泡,限制了由指定气泡发生器产生的主气泡的生长。