公开(公告)号：US20190170651A1

公开(公告)日：2019-06-06

申请号：US16313761

申请日：2017-06-30

申请人： KYOTO UNIVERSITY ,  HORIBA, Ltd.

发明人： Masayuki NISHI ,  Kazuyuki HIRAO ,  Daisuke TERANISHI ,  Hiroki ITASAKA ,  Nobuyuki NAKA ,  Yoshito OKUNO ,  Shinsuke KASHIWAGI ,  Yasushi NAKATA

IPC分类号： G01N21/65 ,  G01Q70/18 ,  G01Q60/42 ,  G01Q60/40

摘要： A needle-shaped body protrudes from a cantilever made of Si. Furthermore, the rear face of the cantilever is coated with aluminum having a Fermi level higher than that of Si. The cantilever is dipped into an aqueous silver nitride solution containing the ions of Ag serving as a second metal. The electrons of Si flow out to the aqueous silver nitride solution due to the existence of the aluminum, and Ag nanostructures are precipitated at the tip end of the needle-shaped body. A probe for tip-enhanced Raman scattering in which the Ag nanostructures are fixed to the tip end of the needle-shaped body is manufactured. The sizes and shapes of the Ag nanostructures can be controlled properly by adjusting the concentration of the aqueous silver nitride solution and the time during which the cantilever is dipped into the aqueous silver nitride solution.

公开(公告)号：US20050230345A1

公开(公告)日：2005-10-20

申请号：US11020180

申请日：2004-12-27

申请人： Eun Kim ,  Sung Lee ,  Ki Song ,  Kang Park

发明人： Eun Kim ,  Sung Lee ,  Ki Song ,  Kang Park

IPC分类号： G01Q60/22 ,  B44C1/22 ,  G01Q70/18 ,  G11B7/135 ,  G11B9/14

CPC分类号： G01Q60/22 ,  G11B7/1387

摘要： Provided is a method of fabricating a near-field optical probe adapted to a near-field scanning optical microscopy and a near-field information storage device, in which a cantilever and an optical tip are provided in one body and the optical tip is arranged to face the upper portion of the substrate. High-concentrated boron ions are implanted into an uppermost silicon layer of a silicon on insulator (SOI) substrate, and a silicon layer into which boron ions are implanted while the silicon inside the tip is etched to form the hole to act as an etch stop layer, thereby easily removing the silicon inside the tip even with the cantilever exposed, and simplifying the process due to the simultaneous fabrication of the cantilever and the tip.

摘要翻译： 本发明提供一种制造适用于近场扫描光学显微镜和近场信息存储装置的近场光学探针的方法，其中悬臂和光学尖端设置在一体内，并且光学尖端布置成 面对基板的上部。 将高浓度硼离子注入到绝缘体上硅（SOI）衬底的最上层的硅层中，并且注入硼离子的硅层，同时蚀刻尖端内部的硅以形成蚀刻停止孔 从而即使悬臂暴露也容易去除尖端内的硅，并且由于悬臂和尖端的同时制造而简化了工艺。

公开(公告)号：US06923044B1

公开(公告)日：2005-08-02

申请号：US10094408

申请日：2002-03-07

申请人： Victor B. Kley

发明人： Victor B. Kley

IPC分类号： G01Q10/00 ,  G01Q70/02 ,  G01Q70/18 ,  G12B21/02 ,  G12B21/22

CPC分类号： B24B37/11 ,  G01Q70/02 ,  Y10S977/86 ,  Y10S977/872 ,  Y10S977/873

摘要： A probe assembly suited for use in a scanning probe microscope (SPM) system includes a cantilever have an attachment to a main body portion. A suitable tip disposed at the free end of the cantilever provides various functions. According to various embodiments of the invention, the tip and cantilever members have active components to produce kinetic action, thus facilitating the utility of the probe assembly in various SPM applications.

摘要翻译： 适用于扫描探针显微镜（SPM）系统的探针组件包括悬臂具有与主体部分的连接。 设置在悬臂的自由端的合适的尖端提供各种功能。 根据本发明的各种实施例，尖端和悬臂构件具有活动部件以产生动力学作用，从而有助于探针组件在各种SPM应用中的应用。

公开(公告)号：US20050081610A1

公开(公告)日：2005-04-21

申请号：US10756579

申请日：2004-01-13

申请人： Jens Struckmeier ,  Doug Gotthard ,  Ben Ohler

发明人： Jens Struckmeier ,  Doug Gotthard ,  Ben Ohler

IPC分类号： G01Q10/00 ,  G01Q10/06 ,  G01Q60/42 ,  G01Q70/18 ,  H02N2/04 ,  G01N13/10 ,  G01L5/00

CPC分类号： G01Q10/065 ,  G01Q60/42 ,  Y10S977/837 ,  Y10S977/85 ,  Y10S977/863 ,  Y10S977/869 ,  Y10S977/872 ,  Y10S977/881

摘要： A force scanning probe microscope (FSPM) and associated method of making force measurements on a sample includes a piezoelectric scanner having a surface that supports the sample so as to move the sample in three orthogonal directions. The FSPM also includes a displacement sensor that measures movement of the sample in a direction orthogonal to the surface and generates a corresponding position signal so as to provide closed loop position feedback. In addition, a probe is fixed relative to the piezoelectric scanner, while a deflection detection apparatus is employed to sense a deflection of the probe. The FSPM also includes a controller that generates a scanner drive signal based on the position signal, and is adapted to operate according to a user-defined input that can change a force curve measurement parameter during data acquisition.

摘要翻译： 强力扫描探针显微镜（FSPM）和对样品进行力测量的相关方法包括具有支撑样品以使样品沿三个正交方向移动的表面的压电扫描器。 FSPM还包括位移传感器，其测量样品在与表面正交的方向上的运动，并产生相应的位置信号，以便提供闭环位置反馈。 此外，相对于压电扫描器固定探针，而使用偏转检测装置来感测探针的偏转。 FSPM还包括基于位置信号产生扫描器驱动信号的控制器，并且适于根据在数据采集期间可以改变力曲线测量参数的用户定义的输入进行操作。

公开(公告)号：US20050009206A1

公开(公告)日：2005-01-13

申请号：US10788414

申请日：2004-03-01

申请人： Chad Mirkin ,  Jung-Hyurk Lim ,  David Ginger ,  Jwa-Min Nam ,  Ki-Bum Lee ,  Linette Demers ,  Albena Ivanisevic

发明人： Chad Mirkin ,  Jung-Hyurk Lim ,  David Ginger ,  Jwa-Min Nam ,  Ki-Bum Lee ,  Linette Demers ,  Albena Ivanisevic

IPC分类号： G01Q70/12 ,  G01Q60/00 ,  G01Q70/18 ,  G01Q80/00 ,  G03B27/42 ,  G01N33/543

CPC分类号： G03B27/42 ,  Y10S977/857 ,  Y10S977/884 ,  Y10S977/885 ,  Y10S977/886

摘要： The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.

摘要翻译： 本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。 特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。 可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。 图案可以是点直径和线宽小于1,000nm的点或线。 尖端和底物表面可适用于肽和蛋白质光刻。

公开(公告)号：US5990479A

公开(公告)日：1999-11-23

申请号：US978450

申请日：1997-11-25

申请人： Shimon Weiss ,  Marcel Bruchez, Jr. ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez, Jr. ,  Paul Alivisatos

IPC分类号： C12Q1/68 ,  G01N33/533 ,  G01N33/542 ,  G01N33/543 ,  G01N33/58 ,  G01Q70/08 ,  G01Q70/18 ,  G01N1/30 ,  G01N21/63

CPC分类号： C12Q1/6816 ,  B82Y15/00 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T436/24

摘要： A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals.Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material.

摘要翻译： 描述了能够连接到亲和分子的发光半导体纳米晶体化合物。 该化合物包括（1）当被电磁辐射源（窄或宽带宽）激发时，能够发射在窄波段和/或吸收能量的电磁辐射（发光）和/或散射或衍射电磁辐射的半导体纳米晶体 ）或粒子束; 和（2）至少一种连接剂，其具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分。 发光半导体纳米晶体化合物与亲和分子连接以形成能够与正在分析的材料中的可检测物质结合的有机发光半导体纳米晶体探针，并且能够发射窄波段的电磁辐射和/或吸收，散射， 或者当被电磁辐射源（窄带或宽带宽）或粒子束激发时被激发的能量。 探针在氧和/或其他自由基存在下重复暴露于光下是稳定的。 进一步描述了制造发光半导体纳米晶体化合物和制备包含与能够与可检测物质结合的亲和分子连接的发光半导体纳米晶体化合物的有机发光半导体纳米晶体探针的方法。 还描述了使用探针来确定材料中可检测物质的存在的方法。

公开(公告)号：US10605827B2

公开(公告)日：2020-03-31

申请号：US16062585

申请日：2016-12-13

申请人： UNIVERSIDADE FEDERAL DE MINAS GERAIS—UFMG ,  INSTITUTO NACIONAL DE METROLOGIA, QUALIDADE E TECNOLOGIA—INMETRO

发明人： Thiago De Lourenço E Vasconcelos ,  Bruno Santos De Oliveira ,  Carlos Alberto Achete ,  Braulio Soares Archanjo ,  Ado Jorio De Vasconcelos ,  Luiz Gustavo De Oliveira Lopes Cançado ,  Wagner Nunes Rodrigues ,  Caroline Arantes Da Silva Wetzstein ,  Rogerio Valaski ,  Cassiano Rabelo E Silva

IPC分类号： G01Q60/22 ,  G01Q70/10 ,  G01R1/067 ,  G01Q70/18

摘要： Described is a device for use in scanning probe microscopy and to a method for manufacturing same. The metallic device has a single body with two parts, wherein the second part has a submicrometric point that defines a nanoscale apex. Also provided is a method for manufacturing a high optical efficiency probe for scanning probe microscopy.

公开(公告)号：US09255944B1

公开(公告)日：2016-02-09

申请号：US14665121

申请日：2015-03-23

申请人： National Applied Research Laboratories

发明人： Chun-Ting Lin ,  Ming-Hua Shiao ,  Shu-Hung Tung ,  Mao-Nan Chang

IPC分类号： G01Q70/14 ,  G01Q70/18

CPC分类号： G01Q70/18 ,  G01Q70/14

摘要： A platinum-platinum silicide modified silicon composite tip apex, and a method for forming the aforesaid tip apex are disclosed, where a metallic precursor solution and a silicon probe are reacted to form a local platinum nano-structure, which could be precisely controlled with local selectivity, and a local platinum silicide layer is formed between the platinum nano-structure and the silicon probe with an atmospheric microwave annealing (a-MWA) process conducted as well, largely enhancing the conductivity of the tip and spatial resolution of the field detection in field sensitive scanning probe microscopy. In addition to exemption from a stray-field effect and thus having better image quality, the platinum silicide-containing probe could more efficiently enhance the interfacial electron transfer efficiency as compared to the probe tip having only a platinum nano-structure, so that the probe could be applicable to a controlled conductive probe having high spatial resolution.

摘要翻译： 公开了一种铂 - 铂硅化物改性硅复合顶尖，以及形成上述顶尖的方法，其中使金属前体溶液和硅探针反应形成局部铂纳米结构，其可以用局部 选择性，并且在铂纳米结构和硅探针之间形成局部铂硅化物层，同时进行大气微波退火（a-MWA）工艺，大大提高了尖端的导电性和场检测的空间分辨率 场敏感扫描探针显微镜。 与仅具有铂纳米结构的探针头相比，除了免除杂散场效应并且因此具有更好的图像质量之外，与仅具有铂纳米结构的探针头相比，含铂硅化物探针可以更有效地提高界面电子转移效率，使得探针 可以适用于具有高空间分辨率的受控导电探针。

公开(公告)号：US20140123348A1

公开(公告)日：2014-05-01

申请号：US14138305

申请日：2013-12-23

申请人： UT-BATTELLE, LLC

发明人： Barbara R. Evans ,  Ida Lee

IPC分类号： G01Q70/02 ,  G01Q70/18

CPC分类号： G01Q60/42 ,  B82Y35/00 ,  G01Q70/02 ,  G01Q70/06 ,  G01Q70/18

摘要： A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

摘要翻译： 提供了一种用于功能化悬臂的方法，其包括提供具有多个通道的保持器，每个通道具有用于接收悬臂探头和多个探针的宽度。 多个悬臂探针通过弹簧夹固定在保持器的多个通道上。 孔板的孔填充有官能化溶液，其中孔板中的相邻孔被分开大致等于分离多个通道的相邻通道的尺寸的尺寸。 固定在保持器的多个通道内的每个悬臂探头被施加到容纳在孔板的孔中的官能化溶液。

公开(公告)号：US08656511B2

公开(公告)日：2014-02-18

申请号：US12763614

申请日：2010-04-20

申请人： Fan Gang Tseng ,  Hui Wen Cheng ,  Wun Yuan Jheng

发明人： Fan Gang Tseng ,  Hui Wen Cheng ,  Wun Yuan Jheng

IPC分类号： G01Q60/40 ,  G01Q60/38 ,  G01Q70/18

CPC分类号： G01Q60/40

摘要： A method for attaching a conductive particle to the apex of a probe tip comprises the steps of: moving the apex of a probe tip close to a conductive particle and applying a bias voltage between the probe tip and the conductive particle so that the conductive particle can permanently attach to the apex. The method uses only a bias voltage to transfer and attach conductive particles to the apex of a probe tip, and no surface treatment of the probe tip is required.

摘要翻译： 用于将导电粒子附着到探针尖端的顶点的方法包括以下步骤：将探针尖端的顶点靠近导电粒子移动并在探针尖端和导电粒子之间施加偏置电压，使得导电粒子可以 永久性地附着到顶点。 该方法仅使用偏置电压将导电颗粒转移并附着到探针尖端的顶点，并且不需要对探针尖端进行表面处理。