发明申请
- 专利标题： SINGLE MOLECULE DETECTION PLATFORM, MANUFACTURING METHOD THEREOF AND METHOD USING THE SAME
- 专利标题（中）： 单分子检测平台及其制造方法及其使用方法
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申请号： US12944151申请日： 2010-11-11
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公开(公告)号： US20110117587A1公开(公告)日： 2011-05-19
- 发明人: Fan Gang Tseng , Sheng Hsun Wu , Ming Hung Chen
- 申请人： Fan Gang Tseng , Sheng Hsun Wu , Ming Hung Chen
- 申请人地址： TW HSINCHU
- 专利权人： NATIONAL TSING HUA UNIVERSITY
- 当前专利权人： NATIONAL TSING HUA UNIVERSITY
- 当前专利权人地址： TW HSINCHU
- 优先权： TW098138545 20091113
- 主分类号： C12Q1/42
- IPC分类号： C12Q1/42 ; C12M1/34 ; B05D3/10
摘要：
A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface of the light-transmissive substrate is etched to form a plurality of cone-shaped structures. Each spherical particle is disposed on top of each cone-shaped structure. The sizes of the plurality of spherical particles are suitable to allow only a single protein to be attached to each spherical particle. The thin film is deposited on the surface of the plurality of cone-shaped structures and acts as a reflective layer of one-dimensional waveguide. The plurality of spherical particles is not covered by the thin film.
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