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    Biosensor apparatus and methods of use
    3.
    发明申请
    Biosensor apparatus and methods of use 审中-公开
    生物传感器装置及使用方法

    公开(公告)号：US20060134713A1

    公开(公告)日：2006-06-22

    申请号：US11284097

    申请日：2005-11-21

    申请人： Dennis Rylatt ,  Alastair Hodges ,  Ronald Chatelier

    发明人： Dennis Rylatt ,  Alastair Hodges ,  Ronald Chatelier

    IPC分类号： G01N33/537 ,  C12M1/34 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54326 ,  Y10T29/49124

    摘要： Disclosed herein are methods and devices for detecting the presence of an analyte of interest. A biosensor device can include a reaction chamber and an electrochemical detection chamber. The reaction chamber can include at least one immobilized binding site and a probe conjugate adapted to bind to at least one of the target analyte and the immobilized binding site, while the detection chamber can include electrodes for detecting an electrochemical reaction. If present, the target analyte in the fluid sample results in a change in the amount of probe conjugate bound in the reaction chamber, which can be detected electrochemically in the detection chamber.

    摘要翻译： 本文公开了用于检测感兴趣的分析物的存在的方法和装置。 生物传感器装置可以包括反应室和电化学检测室。 反应室可以包括至少一个固定的结合位点和适于结合至少一个目标分析物和固定的结合位点的探针结合体，而检测室可以包括用于检测电化学反应的电极。 如果存在，则流体样品中的目标分析物导致在反应室中结合的探针结合物的量的变化，其可以在检测室中电化学检测。

    ELECTROCHEMICAL CELL
    4.
    发明申请
    ELECTROCHEMICAL CELL 有权
    电化学细胞

    公开(公告)号：US20090020438A1

    公开(公告)日：2009-01-22

    申请号：US12196704

    申请日：2008-08-22

    申请人： Alastair Hodges

    发明人： Alastair Hodges

    IPC分类号： G01F1/64 ,  G01N27/26

    CPC分类号： G01N27/26 ,  G01N27/3274

    摘要： The present invention relates to electrochemical cells including a first working electrode 32, a first counter electrode 34, a second working electrode 36, and a second counter electrode 38, wherein the electrodes are spaced such that reaction products from the first counter electrode 34 arrive at the first working electrode 32, and reaction products from the first and second counter electrodes 34, 38 do not reach the second working electrode 36. Also provided is a method of using such electrochemical cells for determining the concentration of a reduced or oxidized form of a redox species with greater accuracy than can be obtained using an electrochemical cell having a single working and counter electrode.

    摘要翻译： 本发明涉及包括第一工作电极32，第一对电极34，第二工作电极36和第二对电极38的电化学电池，其中电极间隔开，使得来自第一对电极34的反应产物到达 第一工作电极32以及来自第一和第二对置电极34,38的反应产物未到达第二工作电极36.还提供了使用这种电化学电池来确定还原或氧化形式的浓度的方法 具有比使用具有单一工作电极和对电极的电化学电池可获得的精度更高的氧化还原物质。

    Sensor with improved shelf life
    6.
    发明授权
    Sensor with improved shelf life 失效
    传感器具有更好的保质期

    公开(公告)号：US06652734B1

    公开(公告)日：2003-11-25

    申请号：US09664688

    申请日：2000-09-19

    申请人： Alastair Hodges ,  Ronald Chatelier

    发明人： Alastair Hodges ,  Ronald Chatelier

    IPC分类号： A61N2730

    CPC分类号： A61N1/0492 ,  A61B5/14539 ,  A61B5/1486 ,  A61N1/0476 ,  A61N1/05 ,  G01N27/30 ,  G01N27/3271

    摘要： The present invention provides a metal electrode stabilised by a coating, the coating comprising a sulfur containing moiety in its molecular structure. The coating may also include a hydrophilic group and a spacer between the sulfur containing moiety and the hydrophilic group. Preferably, the sulfur containing moiety is selected from the group comprising thiol, disulfide and SOx, and the hydrophilic group is selected from the group comprising hydroxyl, amine, carboxyl, carbonyl, oligo (ethylene oxide) chain, and zwitterionic species. Compounds useful in the present invention include 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, 4-carboxythiophene, cysteine, homocysteine, and cystine.

    摘要翻译： 本发明提供了通过涂层稳定的金属电极，该涂层包含其分子结构中的含硫部分。 涂层还可以包括亲水基团和含硫部分和亲水基团之间的间隔基。 优选地，含硫部分选自硫醇，二硫化物和SO x，亲水基团选自羟基，胺，羧基，羰基，低聚（环氧乙烷）链和两性离子物质。 可用于本发明的化合物包括2-巯基乙醇，2-巯基乙胺，3-巯基丙酸，噻吩，4-羧基噻吩，半胱氨酸，高半胱氨酸和胱氨酸。

    Hemoglobin sensor
    7.
    发明授权
    Hemoglobin sensor 有权
    血红蛋白传感器

    公开(公告)号：US06632349B1

    公开(公告)日：2003-10-14

    申请号：US09616512

    申请日：2000-07-14

    申请人： Alastair Hodges ,  Ron Chatelier ,  Thomas Beck

    发明人： Alastair Hodges ,  Ron Chatelier ,  Thomas Beck

    IPC分类号： G01N27327

    CPC分类号： C12Q1/004 ,  C12Q1/006 ,  G01N33/84

    摘要： The present invention relates to a device and method for measuring hemoglobin in a fluid sample. The device comprises a disposable electrochemical cell, such as a thin layer electrochemical cell, containing a reagent capable of being reduced by hemoglobin. A suitable fluid sample that may be analyzed according the present invention is whole blood. If the hemoglobin to be analyzed is present in red blood cells, a lysing agent may be added to the sample to release the hemoglobin prior to analysis.

    摘要翻译： 本发明涉及一种用于测量流体样品中血红蛋白的装置和方法。 该装置包括一次性电化学电池，例如薄层电化学电池，其含有能够被血红蛋白还原的试剂。 根据本发明可以分析的合适的流体样品是全血。 如果要分析的血红蛋白存在于红细胞中，则可以在分析前将裂解剂加入样品中以释放血红蛋白。

    Electrochemical method for measuring chemical reaction rates
    8.
    发明授权
    Electrochemical method for measuring chemical reaction rates 有权
    用于测量化学反应速率的电化学方法

    公开(公告)号：US06444115B1

    公开(公告)日：2002-09-03

    申请号：US09616556

    申请日：2000-07-14

    申请人： Alastair Hodges ,  Ron Chatelier

    发明人： Alastair Hodges ,  Ron Chatelier

    IPC分类号： G01N2726

    CPC分类号： G01N33/84 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3272

    摘要： The present invention relates to the measurement of the progress of a chemical reaction that generates an electroactive reaction product that is subsequently detected at an electrode amperometrically or coulometrically. The method is useful in applications where it is desirable to follow the progress of a chemical reaction, particularly in sensor applications where the progress of the reaction of an analyte can be useful in determining the analyte concentration.

    摘要翻译： 本发明涉及产生电活性反应产物的化学反应的进展的测量，随后在电极电位或电量法检测电极。 该方法在希望遵循化学反应进程的应用中是有用的，特别是在分析物的反应进程可用于测定分析物浓度的传感器应用中。

    Method and apparatus for electrochemical analysis
    9.
    发明授权
    Method and apparatus for electrochemical analysis 有权
    电化学分析方法和装置

    公开(公告)号：US08323464B2

    公开(公告)日：2012-12-04

    申请号：US11138080

    申请日：2005-05-25

    申请人： Jerry T. Pugh ,  Alastair Hodges ,  Garry Chambers

    发明人： Jerry T. Pugh ,  Alastair Hodges ,  Garry Chambers

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3272

    摘要： Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes a longitudinally extending reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. An array of such sensors is further disclosed including connective flaps for joining adjacent sensors. In use, the array of sensors can be stored in a folded configuration and dispensed individually.

    摘要翻译： 公开了用于研究生理样品的电化学传感器和制造方法。 传感器包括具有电极和试剂的纵向延伸的反应池，以及用于与仪表电连通的横向间隔的电接触点。 还公开了一种这样的传感器的阵列，包括用于连接相邻传感器的连接翼片。 在使用中，传感器阵列可以以折叠的形式存储并单独分配。

    Method and apparatus for electrochemical analysis
    10.
    发明申请
    Method and apparatus for electrochemical analysis 有权
    电化学分析方法和装置

    公开(公告)号：US20070205103A1

    公开(公告)日：2007-09-06

    申请号：US11284136

    申请日：2005-11-21

    申请人： Alastair Hodges ,  Jerry Pugh ,  Garry Chambers

    发明人： Alastair Hodges ,  Jerry Pugh ,  Garry Chambers

    IPC分类号： G01N33/487

    CPC分类号： G01N27/3272

    摘要： Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes an electrochemical reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. Further described herein is a multi-chambered sensor having an electrochemical reaction cell and an immunological cell. The multi-chambered cell can also include a pre-chamber.

    摘要翻译： 公开了用于研究生理样品的电化学传感器和制造方法。 传感器包括具有电极和试剂的电化学反应池，以及用于与仪表电连通的横向间隔的电接触点。 本文进一步描述的是具有电化学反应池和免疫细胞的多室传感器。 多室单元还可以包括预制室。