知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.055 秒)

    Vanilloid receptor ligands and their use in treatments
    1.
    发明授权
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US08227469B2

    公开(公告)日：2012-07-24

    申请号：US12417092

    申请日：2009-04-02

    申请人： Chenera Balan ,  Ning Chen ,  Elizabeth M. Doherty ,  Vijay Keshav Gore ,  Mark H. Norman ,  Hui-Ling Wang

    发明人： Chenera Balan ,  Ning Chen ,  Elizabeth M. Doherty ,  Vijay Keshav Gore ,  Mark H. Norman ,  Hui-Ling Wang

    IPC分类号： C07D401/00

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    RAF KINASE MODULATORS AND METHODS OF USE
    3.
    发明申请
    RAF KINASE MODULATORS AND METHODS OF USE 失效
    RAF激酶调节剂及其使用方法

    公开(公告)号：US20100324047A1

    公开(公告)日：2010-12-23

    申请号：US12663504

    申请日：2008-06-05

    申请人： Adrian L. Smith ,  Elizabeth M. Doherty ,  Qi Huang ,  Gang Liu

    发明人： Adrian L. Smith ,  Elizabeth M. Doherty ,  Qi Huang ,  Gang Liu

    IPC分类号： A61K31/502 ,  C07D473/00 ,  C07D487/04 ,  A61K31/52 ,  A61K31/519 ,  A61P35/00

    CPC分类号： C07D487/04 ,  C07D473/00

    摘要： The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

    摘要翻译： 本发明包括能够调节Raf激酶活性的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它与癌症相关的病症。 化合物具有通式（I），其中A1，A2，A3，A4，A5，A6，A7，A8，A9，键合B，X，环Z1和Z2中的每一个，R1和R3如本文所定义。 本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。