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    Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections
    3.
    发明申请
    Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections 审中-公开
    用于测定和显微镜/成像检测的寡核苷酸缀合物的方法和/或用途

    公开(公告)号：US20120258881A1

    公开(公告)日：2012-10-11

    申请号：US13302890

    申请日：2011-11-22

    Applicant: David A. Schwartz ,  Jimmy Williams ,  Xinfang Zhao ,  Chunfang Zhao ,  William B. Busa ,  Stephen J. Kron ,  Amy Catherine Flor

    Inventor： David A. Schwartz ,  Jimmy Williams ,  Xinfang Zhao ,  Chunfang Zhao ,  William B. Busa ,  Stephen J. Kron ,  Amy Catherine Flor

    IPC: C12Q1/68 ,  G01N21/76 ,  G01N21/00 ,  G01N21/59 ,  G01N21/47 ,  G01N21/64 ,  G01N21/25 ,  G01N21/66 ,  G01N21/65 ,  G01N24/00 ,  G01N27/72 ,  C40B30/04 ,  C12Q1/70 ,  B82Y15/00

    CPC classification number: C12Q1/6804 ,  C07H21/00 ,  C12Q1/6834 ,  C12Q2565/113

    Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and microscopy/imaging detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

    Abstract translation: 本公开涉及用于测定和显微镜/成像检测和相关系统和/或试剂盒的寡核苷酸缀合物的方法和/或用途。 某些方法涉及用于在检测测定中检测样品的一种或多种生物学靶标的方法，其包括：向包含一种或多种生物靶标的样品提供包含结合部分和寡核苷酸序列的分子探针; 将一种或多种生物靶与结合部分结合; 向所述样品提供可检测组分，其中所述可检测组分包含与与所述分子探针的寡核苷酸序列互补的寡核苷酸序列缀合的信号产生部分; 将靶结合分子探针的寡核苷酸序列杂交到可检测组分; 以及检测由所述可混合的可检测组分产生的信号。 本文公开了各种其它实施例，应用等。

    Animal model for detection of vulnerable plaques
    5.
    发明授权
    Animal model for detection of vulnerable plaques 失效
    用于检测脆弱斑块的动物模型

    公开(公告)号：US06580016B2

    公开(公告)日：2003-06-17

    申请号：US09760182

    申请日：2001-01-12

    Applicant: Paul S. Teirstein ,  Kenneth W. Carpenter ,  Istvan Szinai ,  David A. Schwartz

    Inventor： Paul S. Teirstein ,  Kenneth W. Carpenter ,  Istvan Szinai ,  David A. Schwartz

    IPC: A01K6700

    CPC classification number: A61K49/126 ,  A61B6/4057 ,  A61B6/481 ,  A61B6/508 ,  A61K49/0442 ,  A61K49/085 ,  A61K51/065 ,  G01N33/92 ,  G01N2400/40 ,  G01N2800/323

    Abstract: The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a biologically compatible detectable lipid-avid agent, the detectable lipid-avid agent is allowed to penetrate arterial walls and attach to any lipid accumulations of oxidized LDL-cholesterol in arterial walls in the wall of an artery; unbound detectable lipid-avid agent is allowed to clear from the body by natural processes, and the presence of the detectable lipid-avid agent attached to the lipid accumulation in the wall of the artery is detected. Detection of bound lipid-avid agent indicates the presence of a vulnerable plaque and predicts a heightened risk of lethal heart attack or thrombus. The detectable lipid-avid agent is selected for its ability to penetrate arterial walls and bind with oxidized LDL-cholesterol in the lipid accumulation in a vulnerable plaque. Alternatively, macrophage-avid agents, for example a lipid-avid agent attached to a macrophage-specific antibody, can be used in the invention methods. The invention further includes methods for in vitro assays for detecting vulnerable plaque and a porcine animal model of vulnerable plaque useful for testing treatment modalities.

    Abstract translation: 本发明提供了在有需要的受试者中检测易损斑块的体内方法。 在本发明方法中，给予受试者诊断量的生物相容性可检测的脂质 - 抗体试剂，允许可检测的脂质激动剂渗透动脉壁并附着于壁中动脉壁中氧化的LDL-胆固醇的任何脂质积聚 的动脉 通过天然过程使未结合的可检测的脂质 - 抗体试剂从身体中清除，并且检测附着在动脉壁中的脂质积聚的可检测的脂质激动剂的存在。 检测结合的脂质抗体剂表明存在易受伤害的斑块，并预测致死性心脏病发作或血栓的风险增加。 选择可检测的脂质抗体试剂，以其穿透动脉壁并与氧化的LDL-胆固醇结合在易损斑块中的脂质积聚中。 或者，巨噬细胞激动剂，例如与巨噬细胞特异性抗体连接的脂质 - 抗体试剂可用于本发明的方法中。 本发明还包括用于检测易损斑块的体外测定方法和用于测试治疗方式的易损斑块的猪动物模型。

    Chemical compounds
    6.
    发明授权
    Chemical compounds 失效
    化合物

    公开(公告)号：US6001826A

    公开(公告)日：1999-12-14

    申请号：US915871

    申请日：1992-07-20

    Applicant: Barry A Murrer ,  David A Schwartz

    Inventor： Barry A Murrer ,  David A Schwartz

    IPC: A61K31/395 ,  A61K31/555 ,  A61K31/34

    CPC classification number: A61K31/395

    Abstract: Pharmaceutical compositions containing as active ingredients a linked cyclic compound of the general formula IZ--(A).sub.n --Y (I)in which Z and Y are independently cyclic polyamine moieties having from 9 to 32 ring members and from 3 to 8 amine nitrogen atoms in the ring, A is a linking atom or group, and n is O or an integer from 1 to 6, are indicated for the treatment of viral infections, and preventative administration, especially for retroviral infections.

    Abstract translation: 含有通式IZ-（A）nY（I）的连接的环状化合物的药物组合物，其中Z和Y独立地为具有9至32个环成员的环状多胺部分和3-8个胺氮原子 环，A为连接原子或基团，n为0或1至6的整数，用于治疗病毒感染，预防性施用，特别是逆转录病毒感染。

    Wide memory architecture vector processor using nxP bits wide memory bus for transferring P n-bit vector operands in one cycle
    7.
    发明授权
    Wide memory architecture vector processor using nxP bits wide memory bus for transferring P n-bit vector operands in one cycle 失效
    宽存储器架构矢量处理器，使用nxP位宽的存储器总线，用于在一个周期内传输P n位向量操作数

    公开(公告)号：US5928350A

    公开(公告)日：1999-07-27

    申请号：US840178

    申请日：1997-04-11

    Applicant: David B. Shu ,  David A. Schwartz ,  Lap-Wai Chow

    Inventor： David B. Shu ,  David A. Schwartz ,  Lap-Wai Chow

    IPC: G06F9/30 ,  G06F9/38 ,  G06F15/78 ,  G06F9/312

    CPC classification number: G06F15/8069 ,  G06F9/30141 ,  G06F9/3826 ,  G06F9/3885 ,  G06F9/3887

    Abstract: A wide memory architecture is provided for storing data associated with a vector processor. Additionally, a method for accessing a wide memory architecture is provided. The wide memory architecture includes a memory for storing an array of vector operands. The memory is coupled to a data bus which provides an access pathway connecting the memory to a processor. The wide memory architecture further includes at least one staging buffer disposed between the memory and the processor. The staging buffer is capable of providing intermediate storage of a vector operand upon which a function can be performed by the processor.

    Abstract translation: 提供了用于存储与矢量处理器相关联的数据的宽存储器架构。 另外，提供了用于访问宽存储器架构的方法。 宽存储器架构包括用于存储向量操作数的阵列的存储器。 存储器耦合到数据总线，数据总线提供将存储器连接到处理器的访问路径。 宽的存储器架构还包括设置在存储器和处理器之间的至少一个分级缓冲器。 分段缓冲器能够提供向量操作数的中间存储器，由此可以由处理器执行功能。

    Computer processing element having first and second functional units accessing shared memory output port on prioritized basis
    8.
    发明授权
    Computer processing element having first and second functional units accessing shared memory output port on prioritized basis 失效
    计算机处理元件具有第一和第二功能单元，以优先级为基础访问共享存储器输出端口

    公开(公告)号：US5481736A

    公开(公告)日：1996-01-02

    申请号：US018683

    申请日：1993-02-17

    Applicant: David A. Schwartz ,  James J. Radigan

    Inventor： David A. Schwartz ,  James J. Radigan

    IPC: G06F9/38 ,  G06F9/30

    CPC classification number: G06F9/3885

    Abstract: A processing element (42) design is provided for improving performance and reducing the number (30') of memory ports by eliminating the dedication of ports to specific functional units (22, 24, 26, 28) and by providing data paths (46, 48, 50, 52) to other forward results from functional unit outputs directly to other functional unit inputs.

    Abstract translation: 提供了一种处理元件（42）设计，用于通过消除对特定功能单元（22,24,26,28）的端口的贡献来提高性能并减少存储器端口的数量（30'），并且通过提供数据路径（46， 48,50,52）将功能单元输出的其他前向结果直接传送到其他功能单元输入。

    Preparation and/or purification of oligonucleotide conjugates
    10.
    发明授权
    Preparation and/or purification of oligonucleotide conjugates 有权
    寡核苷酸共轭物的制备和/或纯化

    公开(公告)号：US08846875B2

    公开(公告)日：2014-09-30

    申请号：US13578752

    申请日：2011-02-11

    Applicant: David A. Schwartz ,  Leopoldo G. Mendoza

    Inventor： David A. Schwartz ,  Leopoldo G. Mendoza

    IPC: A61K47/00 ,  C07K1/22 ,  A61K47/48

    CPC classification number: C07K1/22 ,  A61K47/6807 ,  A61K47/6835 ,  C07K16/44 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/41 ,  C07K2319/43

    Abstract: Methods, systems and/or kits for the preparation, purification and isolation of oligonucleotide conjugates, comprising conjugation of modified antibodies or proteins with at least one modified oligonucleotide at greater than 80% efficiency to form oligonucleotide conjugates and isolating the oligonucleotide conjugates from the conjugation solution by binding the conjugates to an immobilized binder, wherein the binder may be a metal ion or an antibody.

    Abstract translation: 用于制备，纯化和分离寡核苷酸缀合物的方法，系统和/或试剂盒，包括修饰的抗体或蛋白质与至少一种修饰的寡核苷酸以大于80％的效率缀合以形成寡核苷酸缀合物并从缀合溶液中分离寡核苷酸共轭物 通过将缀合物结合到固定的粘合剂上，其中粘合剂可以是金属离子或抗体。

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