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公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
Applicant: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
Inventor： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC: C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC classification number: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
Abstract translation: 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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2.发明授权Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof 失效含有抑制凋亡的溶血磷脂酸的组合物及其用途公开(公告)号：US06495532B1
公开(公告)日：2002-12-17
申请号：US09381489
申请日：2000-02-28
Applicant: Ian C. Bathurst , Matthew W. Foehr , J. Graham Goddard , Samiul R. Umansky , John D. Bradley , Donald H. Picker
Inventor： Ian C. Bathurst , Matthew W. Foehr , J. Graham Goddard , Samiul R. Umansky , John D. Bradley , Donald H. Picker
IPC: A61K3166
CPC classification number: B82Y5/00 , A61K31/07 , A61K31/66 , A61K45/06 , A61K2300/00
Abstract: The present invention provides therapeutic compositions containing lysophosphotidic acids, methods for making the compositions, and methods of using the compositions in the preservation and treatment of organs.
Abstract translation: 本发明提供含有溶血磷脂酸的治疗组合物，制备组合物的方法，以及在保存和治疗器官中使用该组合物的方法。
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公开(公告)号：US20100137365A1
公开(公告)日：2010-06-03
申请号：US12656370
申请日：2010-01-28
Applicant: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
Inventor： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC: A61K31/445 , A61P31/12 , A61P31/14 , C07D211/46 , C07D207/12 , C07C237/42 , A61K31/402 , A61K31/166
CPC classification number: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
Abstract translation: 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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4.发明授权Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof 失效含有溶血磷脂酸的组合物，其存在凋亡及其用途公开(公告)号：US07259273B1
公开(公告)日：2007-08-21
申请号：US11236429
申请日：2005-09-26
Applicant: John G. Goddard , Donald H. Picker , Samuil R. Umansky , Steven Price , Jac C. Wijkmans , Edward A. Boyd , Anthony D. Baxter
Inventor： John G. Goddard , Donald H. Picker , Samuil R. Umansky , Steven Price , Jac C. Wijkmans , Edward A. Boyd , Anthony D. Baxter
IPC: C07C305/00 , A61K31/66
CPC classification number: C07F9/091
Abstract: The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
Abstract translation: 本发明提供含有溶血磷脂酸的抗凋亡组合物和制备和使用组合物的方法。 此类组合物还可含有LPA增效剂，包括蛋白质，脂质膜结构和聚合物如聚乙二醇。 组合物可另外含有其它药学上有效的试剂，例如药物，抗生素，伤口愈合剂和抗氧化剂。
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5.发明授权Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof 失效含有抑制凋亡的溶血磷脂酸的组合物及其用途公开(公告)号：US06949529B2
公开(公告)日：2005-09-27
申请号：US10267568
申请日：2002-10-08
Applicant: Ian C. Bathurst , Matthew W. Foehr , J. Graham Goddard , Samiul R. Umansky , John D. Bradley , Donald H. Picker
Inventor： Ian C. Bathurst , Matthew W. Foehr , J. Graham Goddard , Samiul R. Umansky , John D. Bradley , Donald H. Picker
CPC classification number: B82Y5/00 , A61K31/07 , A61K31/66 , A61K45/06 , A61K2300/00
Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
Abstract translation: 本发明提供含有溶血磷脂酸的治疗组合物，制备该组合物的方法及其使用方法。
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Patent Agency Ranking
公开(公告)号：US4956454A
公开(公告)日：1990-09-11
申请号：US184140
申请日：1988-04-21
Applicant: James G. Heffernan , Paul C. Hydes , Donald H. Picker
Inventor： James G. Heffernan , Paul C. Hydes , Donald H. Picker
CPC classification number: A61K47/48384 , C07F15/0093 , Y10S514/885 , Y10S530/808
Abstract: Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a monoclonal antibody to provide a moiety which stabilizes the antibody against in vivo hydrolysis.
Abstract translation: 铂配位化合物包含至少一个胺配体和远离键合到胺配体的官能团，该官能团可以与单克隆抗体连接，以提供使抗体稳定的体内水解的部分。
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公开(公告)号：US4851403A
公开(公告)日：1989-07-25
申请号：US41003
申请日：1987-04-21
Applicant: Donald H. Picker , Michael J. Abrams , Jean F. Vollano , Christen M. Giandomenico
Inventor： Donald H. Picker , Michael J. Abrams , Jean F. Vollano , Christen M. Giandomenico
IPC: A61K31/40 , A61K31/555
CPC classification number: A61K31/40 , A61K31/555
Abstract: The present invention relates to a method of potentiating radiation therapy using Co(III) complexes of water soluble, synthetic meso-substituted porphyrins. The method results in the sensitization of both well oxygenated (oxic) and oxygen deficient (hypoxic) tumor cells.
Abstract translation: 本发明涉及使用水溶性合成的内消旋卟啉的Co（III）配合物来增强放射治疗的方法。 该方法导致充氧（oxic）和缺氧（缺氧）肿瘤细胞的敏化。
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公开(公告)号：US4793986A
公开(公告)日：1988-12-27
申请号：US18715
申请日：1987-02-25
Applicant: Anthony J. Serino , Geoffrey W. Henson , David A. Schwartz , Donald H. Picker
Inventor： Anthony J. Serino , Geoffrey W. Henson , David A. Schwartz , Donald H. Picker
IPC: A61K31/715 , A61K33/24 , A61K39/395 , A61K47/48 , A61P35/00 , C07F15/00
CPC classification number: A61K47/48384 , A61K47/4823
Abstract: A composition comprising a pharmaceutically acceptable polysaccharide carrier which has been chemically activated and then linked to platinum in either a +2 or +4 oxidation state through a bidentate oxygen-containing ligand including an amine group coupled to the activated polysaccharide. The composition may be used to link platinum metal remotely to a monoclonal antibody via the oxygen-containing ligand and the polysaccharide carrier such as dextran. The composition is optionally radiolabeled.
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公开(公告)号：US4760156A
公开(公告)日：1988-07-26
申请号：US873131
申请日：1986-06-11
Applicant: James G. Heffernan , Michael J. Cleare , Donald H. Picker
Inventor： James G. Heffernan , Michael J. Cleare , Donald H. Picker
IPC: G01N33/574 , A61K39/395 , A61K47/48 , C07D317/30 , C07F15/00 , C12P21/08 , G01N33/577
CPC classification number: C07F15/0093 , A61K47/48384
Abstract: A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilises the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
Abstract translation: 可通过官能团与单克隆抗体相连的铂配位化合物，该官能团形成部分稳定抗体以抵抗体内水解的部分。 还可以使用这些化合物治疗癌症。
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公开(公告)号：US4727050A
公开(公告)日：1988-02-23
申请号：US667442
申请日：1984-11-01
Applicant: William H. Tamblyn , Edward Rosenberg , Donald H. Picker , Michael W. Lord
Inventor： William H. Tamblyn , Edward Rosenberg , Donald H. Picker , Michael W. Lord
CPC classification number: B01J31/04 , B01J31/06 , B01J31/4046 , B01J2231/321 , B01J2231/325 , B01J2231/4205 , B01J2231/641
Abstract: A catalyst composition comprising a PGM complex bound to a carboxylated polymer containing not more than 5 mol equivalents of carboxylate groups per gram of polymer.
Abstract translation: 一种催化剂组合物，其包含与羧基化聚合物结合的PGM复合物，每克聚合物含有不超过5摩尔当量的羧酸酯基团。
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