摘要:
Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
摘要:
This attenuation coefficient image generation method includes a step of generating an input image (6), a step of generating an intermediate image (7) including an image relating to tissue areas based on the input image (6), and a step of generating an attenuation coefficient image (9) based the intermediate image (7) and known attenuation coefficients of tissue areas.
摘要:
An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected from a comparison between at least two images acquired with the apparatus. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.
摘要:
Systems, methods and devices are provided for fitting kinetic models to measurements of dynamic curves where the kinetic models give rise to nonlinear fitting equations in two or more unknowns that can be formulated so that they are linear in one or more of the unknown parameters and nonlinear in one or more of the unknown parameters. Such systems, methods and devices may be utilized to monitor and characterize the attributes of a given tracer such as a radioactive substance within a body, a drug within the body, a concentration of a substance within a particular medium, and the like.
摘要:
A traceable device and procedure suitable for investigating gastrointestinal motility disorders by measuring transit time of the device as it is passed through the gastrointestinal tract of a patient. The device includes a core material configured to be imaged with a gamma imaging process and optionally also an x-ray imaging process, and a sealing material substantially insoluble in gastrointestinal fluids and fully encapsulating the core material.
摘要:
Apparatus, techniques and systems are described for facilitating identification of a target area during a probe-guided radio-localization surgical procedure. The described apparatus, techniques and systems can be used to implement a nuclear-uptake mode controller integrated into a probe to allow a user to instantly switch between multiple nuclear-uptake modes directly from the probe hand-piece. For example, a nuclear-uptake mode controller integrated into the probe can be used to instantly switch between a high-sensitivity nuclear-up take mode and a high-resolution nuclear-uptake mode to effectively identify the target area in the presence of interfering nuclear signals by better matching the probe's nuclear detection parameters to a search task for that target area.
摘要:
Provided is an intraoral X-ray detector assembly that provides X-ray detection signals to an X-ray imaging apparatus main body, the assembly may comprises: an X-ray irradiation means disposed to emit X-rays toward a dentition to be imaged within an oral cavity of a patient; a close-contact means that can bring the X-ray detection means capable of detecting the X-rays close to the patient's face and can fix the X-ray detection means so as to face an X-ray emission direction of the X-ray irradiation means; and a support means that supports a first shaft extending to the X-ray irradiation means and a second shaft extending to the close-contact means and is mechanically coupled to a connection means between the X-ray imaging apparatus main body.
摘要:
This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.
摘要:
Nuclear medicine (NM) imaging system including first and second NM cameras having camera surfaces that are configured to face each other while imaging patient tissue therebetween. The NM imaging system also includes an immobilization plate that is configured to be positioned between the first and second NM cameras and extend parallel to the camera surface of the first NM camera. The immobilization plate is movable to and from the camera surface of the first NM camera to compress the patient tissue, and the second NM camera is movable to and from the immobilization plate. The second NM camera is oriented with respect to a roll axis that extends parallel to the immobilization plate. The second NM camera is rotatable about the roll axis while the immobilization plate and the first NM camera have fixed positions with respect to each other with the patient tissue therebetween.